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A pre-dose biomarker Ccrn4l for predicting the susceptibility of cisplatin-induced hepatotoxicity
Da-Bin Hwang,Dong-Hoon Won,Yoo-Sub Shin,Shin-Young Kim,Changuk Kim,Jun-Won Yun 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Cisplatin-induced liver injury is one of the limitations of its use as an anti-cancer drug. In particular, individual differences in sensitivity to drug-induced liver injury (DILI) can lead to life-threatening situations. The purpose of this study is to discover which innate genetic factors determine diversity for susceptibility to DILI. Rats undergo a liver prebiopsy and a 3-week postoperative recovery period prior to cisplatin administration. Two days after administration of cisplatin, hepatotoxicity was confirmed through serum biochemical and histopathological analysis. Based on liver-related biochemical test results (ALT, AST, γGT), rats were sub-grouped into the Susceptible (top five) or Resistant (bottom five) group for RNA sequencing using the pre-collected liver samples. As a result, pre-dose 161 genes were differentially expressed between the susceptible and resistant groups. Among them, Ccrn4l, a clock-controlled gene included in the "rhythmic process", was inherently low in gene expression before drug administration in both cisplatin- and acetaminophen-susceptible animals. In addition, in the susceptible group, the innately low expression level of Ccrn4l was maintained even after cisplatin treatment with decreased antioxidants, increased nitration, and apoptosis. When checking the correlation between Ccrn4l, antioxidant catalase, and mitochondrial RNA in the liver, it was confirmed that they showed similar mRNA expression patterns according to individual circadian variation. Surprisingly, Ccrn4l knockdown WB-F344 cells prompted cisplatin-induced mitochondrial dysfunction, apoptosis, and decreased catalase activity. In conclusion, individual innate hepatic Ccrn4l level may be a novel factor affecting cisplatin-induced hepatotoxicity susceptibility by modulating mitochondrial and antioxidant functions.
Da Yun Hwang,Se Bin Jeong,Kyung-Haeng Lee,Kwang-Won Yu,Yun-Jung Bae 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The aim of this study was to investigate the use and the satisfaction of fresh convenience foods, specifically fresh-cut fruits and vegetables according to customer health consciousness. The survey included a total of 1,132 subjects (568 men and 564 women). Subjects were classified into two groups: health conscious consumers (HCC)(n=865) and non-health conscious consumers (NHCC)(n=267). When choosing convenience foods, the HCC group had a higher percentage of respondents who considered eco-labels(p<0.05), while showing a significantly lower proportion of those who considered quantity/bundle size (p<0.05) than the NHCC group did. Overall satisfaction with fresh cut fruits and vegetables was 3.75 points in the HCC group, and this was significantly higher than 3.61 points in the NHCC group (p=0.006). The study results indicate when the customers are health conscious, they are more likely to consider health promoting factors when purchasing fresh convenience foods, resulting in higher level of satisfaction. This work was supported by Cooperative Research Program for Agriculture Science and Technology Development(PJ015285042021), Rural Development Administration, Republic of Korea.