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고성능 리튬 설퍼 전지 구현을 위한 폴리설파이드 억제막
( Hee-tak Kim ),( Jongchan Song ),( Hyungjun Noh ),( Hongkyung Lee ),( Je-nam Lee ),( Dong Jin Lee ),( Yunju Lee ),( Chul Hwan Kim ),( Yong Min Lee ),( Jung-ki Park ) 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
The polysulfide shuttle has been an impediment to the development of lithium-sulfur batteries with high capacity and cycling stability. Here, we report a new strategy to remedy the problem that uses alpha-lipoic acid (ALA), as an electrolyte additive to form a polysulfide rejection layer on the cathode surface via the electrochemical and chemical polymerization of ALA during the first discharge. The poly(ALA) layer formed in situ effectively prevents the polysulfide shuttle and consequently enhances the discharge capacity and cycling stability, owing to the Donnan potential developed between the polysulfide-concentrated cathode and the fixed negative charge-concentrated poly(ALA) layer. The approach, based on a thermodynamic equilibrium and a natural material, encompasses a new scientific strategy and provides a practical methodology for high performance lithium-sulfur batteries.
( Kyoung Tak Kang ),( Joon Hee Park ),( Ho Joong Kim ),( Hwan Mo Lee ),( Kwang Il Lee ),( Ms ),( Hone Hee Jung ),( Hwa Yong Lee ),( Young Bock Shim ),( Ju Woong Jang ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.4
Different from primitive tissue engineering, current tissue engineering and biomedical research focuses on tissue regeneration using stem cells. By autotransplantation, Adult stem cells can overcome problems that embry-onic stem cells have, such as immunologic disharmony, and formation of variant carcinomas, making adult stem cell research more prominent. In differentiation of adult stem cells, mechanical stimuli are one of the most important factors in that they enhance differentiation. In case of mesenchymal stem cells, it can be differentiated into fibro-blasts, chondrocytes, and osteoblasts by the magnitude of mechanical stimuli. Additionally, the magnitude and fre-quency of mechanical stimuli is a key factor to determining the proliferation rate of each tissue. Therefore, the purpose of this research is to study tissue differentiation by mechanical stimuli. Tissue differentiation algorithm by magnitude of mechanical stimuli was suggested, and tissue proliferation and apoptosis was modeled mathematically. The cell density of each phenotype was predicted using numerical models of tissue differentiation and proliferation. Cell experimental data were used to determine differentiation and proliferation patterns. A numerical model predict-ing tissue differentiation by the magnitude and frequency of mechanical stimuli was suggested, and bone fracture healing was simulated. The results from the numerical model analysis, using magnitude and frequency as cell pro-liferation controlling factor, showed better description about bone healing process. With simulation of bone healing process with two numerical models, the model with considering proliferation and apoptosis rate gives more accurateresult. Time for bone fracture healing was shorter in model with the proliferation and apoptosis rate, and more fit to validation data.
A Novel Model of Osteonecrosis in the Knee Joint
( Seung Hwan Hong ),( Hyun Shin Park ),( Cheong Ho Chang ),( In Tak Chu ),( Sae Bom Lee ),( Ju Hee Park ),( Jang Hun Kim ),( Seon Ae Kim ),( Sang Hoon Woo ),( Sun Sin Choi ),( Seok Jung Kim ) 한국조직공학·재생의학회 2010 조직공학과 재생의학 Vol.7 No.1
As the necrotic portions of the epiphysis in the current animal models are focal and the extent of necrosis also varies, these models are not suitable for treatment evaluation such as cell therapy. We will describe a new osteonecrosis model which shows total and constant necrosis of the epiphysis and can be for human treatment evaluation. Fifteen New Zealand white rabbits were used for making the osteonecrosis model. Their right knees were incised longitudinally using an anteromedial approach, and the femoral condyles were exposed. After dissecting the ligaments surrounding the distal femur, the metaphyseal-diaphyseal junction was cut using a saw, and the whole femoral condyle was isolated. After three liquid nitrogen treatments, the isolated femoral condyle was internally fixated to the femoral shaft using two or three k-wires. Radiographs were taken at four, 12, and 24 weeks postoperatively, and five rabbits were sacrificed at each time point. The necrotic regions with portions of the osteotomy areas were extracted, and the tissue sections were stained with hematoxylin-eosin and Masson`s trichrome. The tissue reactions showed sluggish reparative processes in which granulation and fibrous tissue sluggishly penetrated necrotic tissue from the osteotomy sites. Viable osteocytes with well-stained nuclei were not present in necrotic areas at any stage. The distal femoral condyle of the rabbit is an appropriate model for demonstrating osteonecrosis. It is hoped that this model will facilitate future assessments of new, human treatment modalities.
( Eun Hee Seo ),( Kwan Sik Park ),( Min Kyu Jung ),( Seong Woo Jeon ),( Sung Kook Kim ),( Chang Min Cho ),( Yong Hwan Choi ),( Young Oh Kweon ),( Won Young Tak ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Development in colonoscopic equipment and methods has led to a large number of endoscopic diagnosis and treatment for colorectal neoplasms. Endoscopic mucosal resection (EMR) for early colorectal cancer (ECC) is increasing as an alternative to surgery, but there are little reports about long-term outcomes of EMR. The present study analysed the clinical, histologic endoscopic findings and the follow-up data of patients with ECC who underwent EMR and aimed to assess the efficacy and the long-term outcomes. Methods: From Match 2000 to August 2007, EMR was performed for the treatment of ECCs in 69 patients (43 males, 26 females, mean age 60.4 years) at Kyungpook National University Hospital. We retrospectively reviewed their medical records. Tumor size, shape, location, depth and procedure related complications, and immediate and follow-up outcomes were evaluated. Results: For the EMR treated group of lesions, the median size of ECC was 18.8 mm (range 6-25 mm). En-bloc resection was performed in 58 of 70 ECCs (79.5%). The complete resection was achieved in 48 of 70 EGCs (68.6%). Submucosal invasion was found in 13 cases (18.6%), 10 patients of those were oprated, 1 patient underwent an additional EMR, 2 patients were followed up without recurrence. Seventeen cases involved submucosal invasion or resection margin, who received surgery, while 11 surgical specimens discovered no residual tumor. Two perforations occurred following EMR and were treated conservatively with clipping. For 35 patients, information from a mean follow-up of 19.5 months of (range 3-67) months was available and recurrence was observed in six cases (17.1%), in which were hisologically proven tubular adenomas and treated successfully endoscopically. Out of 7 incompletely resected cases without surgery. 3 cases developed benign tumor recurrence without histologic malignancy. Conclusions: Endoscopic mucosal resection is a safe and efficient treatment for early colorectal cancers.
The effectiveness of outpatient pulmonary rehabilitation for chronic lung diseases
( Jun Tak Choi ),( Myoung-hwan Ko ),( Sung-hee Park ),( Jeong-hwan Seo ),( Yu Hui Won ),( Yong Chul Lee ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Objective: To determine whether functional ability of patients with chronic lung diseases could be improved after pulmonaryrehabilitation (PR). Methods: Patients in Regional Respiratory Center were allocated to an eight-week PR program. The PR program consisted of aerobic training, resistance training, upper extremity mobilization and respiratory muscle training. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP), peak cough flow (PCF) for pulmonary function, six minute walk test for physical activity, Modified medical research council (MMRC) dyspnea scale, and COPD assessment test (CAT) were tested and followed after the PR program. Results: Sixteen of fifty-three patients actively completed PR programs and pre- and post-evaluations without follow up loss. Among these 16 patients, eight patients attended the hospital based PR, four attended the home based PR, and the others attended the hospital & home based PR. All of these patients improved in MIP by 7.25 cm H2O, MEP by 9.5 cm H2O, PCF by 23.18 L/min, six minute walking distance by 30.21 m without statistical significance. Conclusion: The results showed that the compliance of out-patient PR programs was approximately 30.3%. Although there was no statistical significance in the pre-post evaluations, the out-patient PR program could produce positive response in chronic lung diseases. Therefore, this study supports the necessity of the active pulmonary rehabilitation for the improvement of physical function and pulmonary function of various chronic lung diseases in Korea.
Chang-Hee Do(도창희),Seon-Ku Kim(김선구),Han-Suk Kang(강한석),Teak-Soon Shin(신택순),Hong-Gu Lee(이홍구),Seong-Keun Cho(조성근),Kyung-Tak Do(도경탁),Ji-Na Song(송지나),Tae-Hun Kim(김태헌),Bong-Hwan Choi(최봉환),Byung-Chan Sang(상병찬 한국생명과학회 2010 생명과학회지 Vol.20 No.6
본 연구는 버크셔 품종에서 PRLR3와 RBP4 후보유전자의 두 개의 대립유전자가 산육형질과 번식형질에 미치는 영향을 조사하였다. 5,919두의 혈통자료, 3,480두의 산육기록과, 244두의 모돈의 775마리의 산자기록을 이용하여 유전능력 평가를 수행하였다. 유전자형 분석은 144두와 156두에서 PRLR3와 RBP4 유전자의 유전자형을 각각 분석하였다. 평가된 개체들의 육종가를 이용 두 마커의 유전자형 효과와 유의 확률을 추정한 결과 PRLR3 유전자는 번식형질의 총산자수(TBN)와 생존산자수(NBA)에서 -0.28과 -0.13두의 상가적 효과를 각각 나타내었다. RBP4 유전자는 일당증체량에서 10.58 g의 우성적 효과를 나타내었다. 그러나 RBP4 유전자의 다형성은 번식형질의 총산자수(TBN)와 생존산자수(NBA)에서 -0.34와 -0.33두의 상가적 유전적 효과를 각각 나타났다. 따라서 PRLR3와 RBP의 B 대립유전자를 선호하는 MAS (Marker Assist Selection) Scheme은 버크셔 품종의 산자수의 개량에 이용할 수 있을 것이다. Two diallelic markers at candidate gene loci, the prolactin receptor 3 (PRLR3) gene and the retinol-binding protein 4 (RBP4) gene were evaluated for their association with growth and litter size traits in Berkshire. Genetic evaluation was conducted for 5,919 pigs with pedigree information, which included 3,480 growth performance records and 775 litter size records of 224 sows. From the same herd, genotyping was carried out on 144 and 156 animals for PRLR3 and RBP4, respectively. After assigning a genotype to subjects in which both parents had a homozygous genotype, numbers of genotyped animals increased to 474 and 338, for the PRLR3 gene and RBP4 gene, respectively. The genotype effects of two markers were estimated with breeding values of the genotyped animals. The additive effects of total number of piglets born and number of piglets born alive in the PRLR3 locus were -0.28 and -0.13, respectively. The dominance effect of the RBP4 locus on average daily gain was -10.58 g. However, the polymorphism of the RBP4 locus in total number of piglets born and number of piglets born alive has shown -0.34 and -0.33 of the additive genetic effects. In view of the results, MAS (marker-assisted selection) favoring B alleles of RBP4 and PRLR3 loci could potentially accelerate the rate of the genetic improvement in the litter size traits.
자가복제 Deoxyribozyme을 이용한 센서 디자인
임희웅(Hee-Woong Lim),이승환(Seung Hwan Lee),양경애(Kyung Ae Yang),유석인(Suk-In Yoo),박태현(Tai Hyun Park),장병탁(Byoung-Tak Zhang) 한국정보과학회 2008 한국정보과학회 학술발표논문집 Vol.35 No.2
최근 DMA와 같은 생체 분자를 이용한 정보 처리 기술에 대한 연구가 활발하게 이루어지고 있다. 이러한 기술의 발전은 분자 수준에서의 생화학적 정보 처리의 가능성을 보여주며, 진단 목적의 유전자 발현 정보 처리와 같은 생물학 목적의 문제 해결을 위한 새로운 방법으로 떠오르고 있다. 생체 분자 정보 처리 기술은 기존의 전자식 컴퓨터와 달리 생체 분자로 표현된 정보를 문자 수준에서 직접 처리함으로써 정보 변환 과정에서의 손실을 줄이고 효과적인 문제 해결을 가능하게 한다. Deoxyribozyme은 DNA이면서도 마치 효소와 같은 특성을 가지며 특정 서열의 DNA나 RNA 분자를 자르거나 이어 붙이는 기능을 가지고 있는 DNA 분자를 말한다. 본 논문에서는 deoxyribozyme을 이용하여 분자 정보 처리의 기본 소자 역할이 가능한 자가복제 deoxyribozyme의 개념적 모델을 제안하고, 이를 바탕으로 목표 분자를 검출하는데 사용 가능한 분자 센서를 디자인한다. 그리고 시뮬레이션을 통해 자가복제 deoxyribozyme의 복제 반응과 센서로서의 기능을 보여준다.
임희웅(Hee-Woong Lim),이승환(Seung Hwan Lee),양경애(Kyung Ae Yang),유석인(Suk-In Yoo),박태현(Tai Hyun Park),장병탁(Byoung-Tak Zhang) 한국정보과학회 2008 한국정보과학회 학술발표논문집 Vol.35 No.2
최근 생체 문자를 이용한 정보 처리 기술의 발전은 분자 수준에서의 생화학적 정보 처리의 가능성을 제시하였으며 더 나아가 유전자 분석이나 질병진단과 같은 의료 목적의 응용 개발을 목표로 하고 있다. 이러한 분자 정보 처리 기술은 기존의 실리콘 컴퓨터 기반의 방법론과는 달리 생화학적 정보를 전기적 신호로의 변환 과정 없이 시험관 내에서 직접 처리하며 결과적으로 정보 손실을 최소화하며 최종 결과를 얻기까지의 절차를 단축시킨다. 그러나 현실적으로 응용 가능한 시스템의 개발은 해당 분자 정보의 특성에 잘 맞는 새로운 모델과 정보 표현 방법, 그리고 새로운 기본 연산자의 도입을 필요로 한다. 본 논문에서는 다양한 패턴 분석 모델의 기본연산이라 할 수 있는 가중치 합 연산의 분자 컴퓨팅 버전을 제시하는데, 분자간의 특이적인 혼성화와 그에 따른 경쟁 반응을 이용하여 가중치를 표현하는 일반화된 모델을 제안한다. 그리고 간단한 바이오-랩 실험 결과를 통해서 본 모델의 가능성을 제시한다.