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( Ju Hee Kim ),( Woong Sik Nam ),( Doo Hyun Lee ),( Su Youn Lee ),( Hung Chan O ),( Jeong Min Joo ),( Kwang Hyeon Liu ),( Jae Yun Han ),( Sung Hwan Ki ),( Tae Cheon Jeong ),( Tae Ho Lee ),( Sang Kyu L 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Cytochrome P450 (cyp) is an important enzyme that can act on xenobiotic substances such as toxic chemicals or drugs. Phenobarbital(PB) has been widely used to induce CYP2B activity to investigate the drug-drug interaction of CTP2B substrate drugs.leelamine is a diterpene compound, and is the current focus of efforts to develop a treatment for diabetes. In this study. we identi-fied the selective and potent inductive effct of leelamine on CYP2B antdoes of 5,10,or 20 mg/kg in male ICR micc for I or 3 days. In liver, the activity of CYP2B significantly increased 3.6-fold after treatment with leelamine,com-pared to vehicle-treated group. Activities of benzyloxy-resorufin O-dealkylase and pentoxyresorufin O-dealkylase significantly increased 6.3-and 5.3-fold, respectively,with a single treatment of 20 mg/kg leelamine for I day. Fur-thermore. immunoblot analysis showed that signifieantly and dose-dependently increased CYP2B10 protein levels in liver.However,PCR results showed that there were no significant changes in the CAR and CYP2B mRNA levels after leelamine treatment. Accordingly, we suggest that leelamine is a novel substitute of PB for the seleetive inudction of CYP2B activity in vivo.
Preparation of antimony films by cyclic pulsed chemical vapor deposition.
Kim, Yeon-Hong,Lim, Gyeong Taek,Kim, Bo-Hye,Ko, Hang Ju,Woo, Hee-Gweon,Kim, Do-Heyoung American Scientific Publishers 2008 Journal of nanoscience and nanotechnology Vol.8 No.10
<P>Cyclic-pulsed plasma-enhanced chemical vapor deposition (PECVD) for the formation of antimony (Sb) thin films was investigated using Sb(i-C3H7)3 and H2 plasma at temperatures of 200-275 degrees C. The effects of deposition temperature on the film properties, such as resistivity, surface roughness, and crystallinity were examined. The film growth rate (thickness/cycle) was found to be in the range of 0.10-0.5 nm/cycle. High substrate temperatures tended to promote low resistivity, high purity, and smooth surface morphology of the films, compared to low substrate temperatures. All of the deposited films were polycrystalline, with higher deposition temperatures yielding a higher crystallinity in the Sb films.</P>
Minimum torsional reinforcement ratio for reinforced concrete members with steel fibers
Ju, Hyunjin,Lee, Deuck Hang,Kim, Kang Su Elsevier 2019 COMPOSITE STRUCTURES -BARKING THEN OXFORD- Vol.207 No.-
<P><B>Abstract</B></P> <P>The current design codes for concrete structures suggest the minimum torsional reinforcement ratio to induce minimum ductile failure after cracking in reinforced concrete (RC) members subjected to torsional moment. However, as the member strengths are quite often lower than the torsional cracking moment strengths even when satisfying minimum torsional reinforcement ratio specified in the current codes, it may not serve the original purpose of preventing brittle failure immediately after cracking. In this study, a rational equation is thus presented for calculating the minimum torsional reinforcement ratio that could provide a sufficient margin of safety in design. The minimum fiber factor to be applied in steel fiber reinforced concrete (SFRC) members is also proposed. The proposed model was found to reflect the effects of torsional cracking strength, longitudinal and transverse reinforcement ratio, and the presence of torsional reinforcement in concrete members. It was also found that as the reserved strength included in the proposed equation is determined based on the test results of the RC members, it contains an appropriate factor of safety for the RC members. In addition, it was confirmed that the minimum fiber factor is conservative compared with the collected test results of the SFRC specimens.</P>
Ju Hee Ko,Jae Kweon Park,Woo Jung Kim,Hang Soo Jo,Yong Il Park 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
A chitinolytic enzyme from the culture filtrates of Pseudomonas fluorescens was purified to apparent homogeneity and its kinetic properties were characterized. The molecular weight of the purified enzyme (NagA) was estimated by SDS–PAGE to be approximately 50 kDa. The optimum pH, temperature, and pH stability of NagA on synthetic substrate pNP-GlcNAc were determined to be pH 6.5, 37oC and pH 6–9, respectively. Its kinetic parameters on pNP-GlcNAc and pNP-(GlcNAc)2 were Km = 0.13 mM and 0.82 mM, and Vmax = 245 and 40 pmol/㎍/min, respectively. Chitinolytic activity of the purified NagA toward natural substrates (GlcNAc)n, n=2-5 was also determined by high performance anion-exchange chromatography with pulsed electrochemical detection (HPAEC-PED). The results suggest that NagA is an exo-type β-N-acetylglucosaminidase yielding GlcNAc as the final product from the chitooligosaccharides. Taken together, this is the first report of an exo-type chitinolytic enzyme based on the comparison of its peptide sequence from other chitinolytic enzyme produced by other microorganisms.
A Clinical Analysis of PTEN Expressions in Breast Cancers
Hang Ju Cho,Jeong Soo Kim,Kee Hwan Kim,Chang Hyeok Ahn,Woo Chan Park,Se Jeong Oh,Sang Seol Jung,Keun Woo Lim,Seock Ah Im 대한암학회 2003 Cancer Research and Treatment Vol.35 No.2
Purpose: The PTEN gene, a novel tumor suppressor,is localized to chromosome 10q23.3 and shares extensivehomology with the cytoskeletal protein, tensin. Ahigh frequency of mutations at the PTEN locus has beendescribed in a variety of neoplasms including breastcancer and Cowden Disease. However, the role of PTENalterations and its association with clinicopathologicalfactors have not been well established. We investigatedthe relationship between the PTEN expression and clinicopathologicalfactors.Materials and Methods: Formalin-fixed, paraffin-embeddedtissues from 105 women with breast cancer wereevaluated for the PTEN expression and were scoredsemi-quantitatively based on staining intensity and distribution.Results were statistically compared with clinicopathologicalfactors.Results: Forty-seven (45%) of the 105 breast cancershad a loss of the PTEN expression. In the recurrent group,19 of 32 (59%) patients showed a loss of the PTEN expression,whereas in the non-recurrent group, only 28 of 73(38%) patients showed a loss of the PTEN expression. Theloss of PTEN expression correlated with estrogen receptors(ER) (p=0.027), recurrence (p=0.046), HER-2/neuoverexpression (p=0.016), disease-free survival (p=0.0163),and overall survival (p=0.0357). In particular, when HER-2/neu was overexpressed, the overall survival rate correlatedwith the loss of PTEN expression statistically(p=0.0454), whereas when HER-2/neu was negative, therewas no correlation (p=0.9808). Progesterone receptor (PR)and disease stage had no relationship with the PTENexpression.Conclusion: Our results support that PTEN plays a roleas a tumor suppressor in breast cancer and is a prognosticfactor in predicting recurrence. (Cancer Researchand Treatment 2003;35:102-108)
Study on the Constituents of Roots of Aceriphyllum rossii
Kim Van, Le Thi,Hung, Tran Manh,Kim, Soo Hyun,Kim, Jin Cheol,Na, MinKyun,Jung, Hyun Ju,Kwack, Seung Jun,Kweon, Kee Tae,Choi, Jae Sue,Lee, Hyeong Kyu,Bae, KiHwan,Min, Byung-Sun WILEY-VCH Verlag 2010 Helvetica chimica acta Vol.93 No.9
<P>A new stereoisomer of a tetrahydrofuranoid lignan, acerifuranoid A (1), and two new oleanane-type triterpenoids, aceriphyllic acids J and K (2 and 3), were isolated from the roots of Aceriphyllum rossii. Their structures were elucidated on the basis of spectroscopic analyses and chemical evidence. These isolated compounds exhibited weak cytotoxic activity against various cancer cell lines with IC<SUB>50</SUB>>150 μM.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img_2010/0018019X-2010-93-9-HLCA200900467-content.gif' alt='wiley_img_2010/0018019X-2010-93-9-HLCA200900467-content'> </P>