http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Huina Zhang (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
Zhang, Huina,Wang, Lin,Park, Jun Beom,Park, Paul,Yang, Victor C,Hollister, Scott J,La Marca, Frank,Lin, Chia-Ying BioMed Central 2009 Arthritis research & therapy Vol.11 No.6
<P><B>Introduction</B></P><P>Earlier work indicates that the cholesterol-lowering drug, simvastatin, is anabolic to chondrogenic expression of rat intervertebral disc (IVD) cells, which suggests a potential role for simvastatin in IVD regeneration. In this study, we expand on our earlier work to test the effectiveness of simvastatin on disc degeneration utilizing a rat tail disc degeneration model.</P><P><B>Methods</B></P><P>30 rats that underwent 21 G needle-puncture at rat tail discs were injected with simvastatin-loaded poly(ethylene glycol)-poly(lactic acid-co-glycolic acid)-poly(ethylene glycol) (PEG-PLGA-PEG) gel (5 mg/ml) or vehicle control at 4 weeks after needle injury. All animals were sacrificed 2 weeks after simvastatin injection. Bone morphogenetic protein-2 (BMP-2), aggrecan, collagen type II, and collagen type I messenger ribonucleic acid (mRNA) expression in the rat nucleus pulposus (NP) were measured by real-time polymerase chain reaction (PCR). <I>In vivo </I>magnetic resonance imaging (MRI) was performed to monitor changes in disc degeneration. Rat discs were also assessed by histology using hematoxylin and eosin (H&E) and safranin O staining. In addition, the NP weight, glycosaminoglycan (sGAG) and DNA content were also measured.</P><P><B>Results</B></P><P>A single dose of simvastatin loaded in thermo-sensitive PEG-PLGA-PEG gel injected into the NP had the trend to increase aggrecan expression and sGAG content, and significantly increased mRNA levels of BMP-2, collagen type II, and the differentiation index (the ratio of collagen type II to collagen type I). The decreased NP weight, T2 intensity, as well as MRI index in the rat tail discs induced by needle puncture were significantly reversed after 2 weeks of simvastatin treatment. In addition, simvastatin treatment also improved histological changes induced by needle puncture.</P><P><B>Conclusions</B></P><P>A single injection of simvastatin loaded in PEG-PLGA-PEG gel into rat tail discs had the potential to retard or regenerate the degenerative disc.</P>
-
Simulation of Tensile Cracking in Earth Structures with an Adaptive RPIM-FEM Coupled Method
Huina Yuan,Chong Peng,Qing Lin,Bingyin Zhang 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.7
The safety issues of geotechnical structures are often related to tension-induced cracking of geomaterials. Conventional finite element analysis often experiences difficulties in re-meshing and adaptively analyzing the crack propagation region. In this work, the Radial Point Interpolation Method (RPIM) is adaptively coupled with the Finite Element Method (FEM) to simulate tensile crack initiation and propagation in earth structures. In the algorithm, FEM mesh in identified crack regions is automatically converted to RPIM nodes and then refined for crack analysis. The behavior of soil under tension and the brittle and quasi-brittle failure types are investigated based on typical tensile test results. Especially, the crack-induced anisotropic and softening behaviors of soils are appropriately simulated using the smeared crack approach. Two types of soil cracking experiments, the four-point bending test and centrifuge model test, were conducted in the laboratory and simulated by the proposed approach. Good agreements between the simulated and experimental results have been obtained, which demonstrates the effectiveness of this coupled method for 2D and 3D simulations of tensile cracking in earth structures.
-
Low-temperature solution selective growth of zinc oxide nanorods on different substrates
Jian Zhang,Lijuan Wan,Xuejiao Chen,Chunran Liu,Huina Hou 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.3
In this paper, regular ZnO nanorods with excellent reproducibility were grown by a simple solution method at low temperature. The growth parameters, which can affect the ZnO nanostructures were studied, including the substrate types, the growth temperature, the growth time and the concentration of the solution. Among these conditions, the influence of different substrates on the resulting nanostructures was investicated carefully. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used to characterize the morphology and microstructure of the as-grown ZnO nanorods. It is concluded that the substrates can affect the ZnO growth remarkably and the selective growth of ZnO is possible through the choice of the substrates.
-
Polysaccharide Hydrogel and its Application Analysis
Nifeng Chen,Huina Zhang,Yinmao Dong,Li Li 한국피부과학연구원 2020 아시안뷰티화장품학술지 Vol.18 No.1
하이드로젤은 수분이 잘 흡수되고 생체 적합성이 우수하여 화학, 제약, 식품, 화장품 등 여러 분야에서 널리 사용된다. 하이드로젤 은 일반적으로 친수성 폴리머소재로 구성된다. 다당류는 천연 중합체 물질로서 분해성 및 생체 적합성으로 많은 인기가 있다. 본 총 설에서는 하이드로젤과 그 분류 및 특성을 논술하고, 바이오의약품 및 화장품 분야에서 다당류 하이드로젤의 응용 및 발전에 대해 분석했다. Hydrogels are widely used in chemical, pharmaceutical, food, cosmetics and other fields for their good water absorption and biocompatibility. Hydrogels are usually composed of hydrophilic polymer materials. Polysaccharides, as natural polymer materials, have attracted much attention because of their degradability and biocompatibility. This review introduced the hydrogel and its classification and characteristics, then emphatically analyzed and prospected the application and development of polysaccharide hydrogel in the field of biomedicine and cosmetics.
-
Impact of Size on Humidity Sensing Property of Copper Oxide Nanoparticles
Yang Gu,Huina Jiang,Zi Ye,Ning Sun,Xuliang Kuang,Weijing Liu,Gaofang Li,Xiaojun Song,Lei Zhang,Wei Bai,Xiaodong Tang 대한금속·재료학회 2020 ELECTRONIC MATERIALS LETTERS Vol.16 No.1
Three sizes of CuO nanosheets were synthesized by hydrothermal method. The structure and morphology of CuO nanosheets were characterized by X-ray difraction and scanning electron microscopy. Dielectrophoresis nano-manipulation technique was employed to arrange the materials on pre-designed Ti/Au electrodes to fabricate the three humidity sensors, and the sensing properties were then tested. The experimental results show that the sensitivity greatly increases with the decreasing size of CuO nanosheets, the sensitivity of sensor a, b, c are 369%, 3278%, 22,611% in 97.3% RH, respectively. The smaller sized CuO nanomaterials have better response characteristic, the response time of sensor a, b, c under 11.3–97.3% RH are 53 s, 49 s, 32 s, respectively. And correspondingly, hysteresis properties and the repeatability are also a little infuenced. In addition, based on complex impedance spectroscopy and multilayer adsorption theory, the impact of size on humidity sensing property was discussed. The results indicated the feasibility to obtain higher performance of humidity sensor, especially the higher sensitivity, via employment the smaller size sensing nanomaterials.
eArticle연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
