Phase II Study on Javanica Oil Emulsion Injection (Yadanzi^®) Combined with Chemotherapy in Treating Patients with Advanced Lung Adenocarcinoma

Lu, Yan-Yan,Huang, Xin-En,Cao, Jie,Xu, Xia,Wu, Xue-Yan,Liu, Jin,Xiang, Jin,Xu, Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Purpose: To investigate the efficacy and safety of Javanica oil emulsion injection (Yadanzi$^{(R)}$) combined with pemetrexed and platinum (PP) for treating patients with advanced lung cancer. Patients and Methods: From June 2011 to June 2013, we recruited 58 patients with advanced lung cancer, and divided them into two groups. Twenty eight patients received Yadanzi$^{(R)}$ (from ZheJiang Jiuxu Pharmaceutical Co., Ltd.) together with PP chemotherapy (combined group), while the others were given only PP chemotherapy (control group). After two cycles of treatment, efficacy and safety of treatment were evaluated. Results: The overall respnse rate [(CR+PR+SD)/(CR+PR+SD+PD)] of the combined group was higher than that of control group (89.7% vs. 86.2%, p>0.05). Regarding rate of life improvement, it was 82.8% in combined group, and 51.7% in the control group (p<0.05). In terms of side effects, leukopenia in combined group was less frequent than that in control group (p<0.05). More patients in the control group were found to suffer liver toxicity. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced lung adenocarcinoma. It can improve the quality of life and reduce the possibility of leukopenia. Further clinical trials with a large sample size should be conducted to confirm whether addition of Yadanzi$^{(R)}$ to chemotherapy could increase the response rate, reduce toxicity, enhance tolerability and improve quality of life for patients with advanced lung cancer.

Clinical Observations on Associations Between the UGT1A1 Genotype and Severe Toxicity of Irinotecan

Lu, Yan-Yan,Huang, Xin-En,Wu, Xue-Yan,Cao, Jie,Liu, Jin,Wang, Lin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: Severe toxicity is commonly observed in cancer patients receiving irinotecan (CPT-11) UDPglucuronosyltransferase1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38 but the relationship between UGT1A1 and severe toxicity remains unclear. Our study aimed to assess this point to guide clinical use of CPT-11. Materials and Methods: 89 cancer patients with advanced disease received CPT-11-based chemotherapy for at least two cycles. Toxicity, including GI and hematologic toxicity was recorded in detail and UGT1A1 variants were genotyped. Regression analysis was used to analyse relationships between these variables and tumor response. Results: The prevalence of grade III-IV diarrhea was 10.1%, this being more common in patients with the TA 6/7 genotype (5 of 22 patients, 22.7%) (p<0.05). The prevalence of grade III-IV neutropenia was 13.4%and also highest in patients with the TA 6/7 genotype (4 of 22 patients; 18.2%) but without significance (p>0.05). The retreatment total bilirubin levels were significantly higher in TA6/7 patients (mean, $12.75{\mu}mol/L$) with compared to TA6/6 (mean, $9.92{\mu}mol/L$) with p<0.05. Conclusions: Our study support the conclusion that patients with a $UGT1A1^*28$ allele (s) will suffer an increased risk of severe irinotecan-induced diarrhea, whether with mid-or low-dosage. However, the $UGT1A1^*28$ allele (s) did not increase severe neutropenia. Higher serum total bilirubin is an indication that patients UGT1A1 genotype is not wild-type, with significance for clinic usage of CPT-11.

Potential Predictors of Sensitivity to Pemetrexed as First-line Chemotherapy for Patients with Advanced Non-Squamous NSCLCs

Lu, Yan-Yan,Huang, Xin-En,Xu, Lin,Liu, De-Gan,Cao, Jie,Wu, Xue-Yan,Liu, Jin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: Pemetrexed (PEM) is effective in first-line treatment for patients with non-squamous non-small cell lung cancer (NSCLC). However there are currently no definitive determinants to certify which patients could benefit from PEM. To improve the efficacy of PEM combined with platinum as first-line therapy for advanced non-squamous NSCLC, we conducted this retrospective study to detect potential determinants of this regimen. Methods: We recruited 109 patients with advanced non-squamous NSCLC who received PEM with a platinum as first-line therapy from June 2006 to February 2013 in Jiangsu Cancer Hospital. Multiple variables (age, sex, smoking, degree of cell differentiation, hemoglobin, platinum drugs combined, positions of metastasis) were selected. Logistic regression analysis was used to analyse relationships between these variables and tumor response. Result: In univariate analysis, we found that age and platinum significantly influenced the results of PEM therapy (P<0.05). In multivariable analysis, no factors were independently significant. Conclusion: Our analysis did not suggest that the age, sex, metastasis of liver or other organs, hemoglobin, smoking history and pathological differentiation are associated with the response of PEM. We should conduct further analyses with larger sample size to reconfirm this issue.

Component-based model for posttensioned steel connections against progressive collapse

Yan Fei Zhu,Chang Hong Chen,Ying Huang,Zhaohui Huang,Yao Yao,Leon M. Keer 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.4

A component-based method for the estimation of the posttensioned (PT) steel frame against progressive collapse is proposed and presented in the current paper. A mechanical model of PT steel connections is developed and benchmarked with experimental data of a PT beam-column substructure from literature. The developd mechanical models of four PT connections are able to capture the initial elastic stiffness, decompression load, and residual stiffness under lateral loading. Then, analysis of a reduced-scale three-storey two-bay PT steel frame is carried out with sufficient accuracy by incorporating the proposed joint model into the frame analysis. The proposed method is then applied to assessing progressive collapse of a one-storey two-bay PT frame under middle column removal scenario, and is verified against existing experimental and ANSYS finite element results. Three resistance mechanism for progressive collapse of the PT frame are evaluated, which consists of angle flexural mechanism, beam compression arching action and strand tensile catenary action. Finally, parameter analyses of the PT frames are conducted to investigate the effects of the connection details on the behavior and resistance of progressive collapse. The proposed model can be used to predict the quasi-static behavior of PT frames under monotonic vertical loading conditions with satisfactory accuracy.

The Changing Face of Chinese Politics and International Relations : The State Of China`s State Apparatus

( Yan Zhong Huang ) 경남대학교 극동문제연구소 2004 ASIAN PERSPECTIVE Vol.28 No.3

Ultimate strength of rectangular concrete-filled steel tubular (CFT) stub columns under axial compression

Yan-sheng Huang,Yue-Ling Long,Jian Cai 국제구조공학회 2008 Steel and Composite Structures, An International J Vol.8 No.2

A method is proposed to estimate the ultimate strength of rectangular concrete-filled steel tubular (CFT) stub columns under axial compression. The ultimate strength of concrete core is determined by using the conception of the effective lateral confining pressure and a failure criterion of concrete under true triaxial compression, which takes into account the difference between the lateral confining pressure provided by the broad faces of the steel tube and that provided by the narrow faces of the steel tube. The longitudinal steel strength of broad faces and that of the narrow faces of the steel tube are calculated respectively due to that buckling tends to occur earlier and more extensively on the broader faces. Finally, the proposed method is verified with experimental results. Corresponding values of ultimate strength calculated by ACI (2005), AISC (1999) and GJB4142-2000 are given respectively for comparison. It is found from comparison that the proposed method shows a good agreement with the experimental results.

Gold nanorods functionalized by a glutathione response near-infrared fluorescent probe as a promising nanoplatform for fluorescence imaging guided precision therapy

Huang, Yan,Liu, Qingluan,Wang, Yunqing,He, Na,Zhao, Rongfang,Choo, Jaebum,Chen, Lingxin The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.25

<P>Theranostics nanoplatforms offer opportunities for imaging-guided precision therapy and hold great potential for clinical applications. In most reported works, the imaging unit has a lack of site selectivity, and is always kept in the “on” modality regardless of whether it is in normal tissues or tumor sites, increasing the risk of unsafe treatment. Herein, we designed a near-infrared (NIR) fluorescence-guided theranostics nanoplatform by integrating the functions of tumor-response and photodynamic therapy (PDT)/photothermal therapy (PTT). A novel NIR fluorescent dye, CyPT, with excellent optical and PDT/PTT properties, was synthesized and linked onto the gold nanorods (AuNRs) to form CyPT-AuNRs nanohybrids<I>via</I>a sulfur-sulfur bond that can be broken by glutathione (GSH) with high selectivity and sensitivity. In normal cells where the concentration of GSH is low, the fluorescence of CyPT is quenched by the AuNRs. By contrast, the high level of GSH in tumor cells leads to the breaking of the sulfur-sulfur bond, resulting in the release of CyPT and the accomplishment of a “off-on” fluorescence response. Followed by precise NIR tumor-imaging diagnosis, the PDT and PTT treatment which rely on the released CyPT and AuNRs, respectively, can be effectively performed. The CyPT-AuNRs nanoplatform has been successfully applied to the treatment of tumor xenograft models and no distinct damage has been observed in the nearby normal tissues. This versatile nanoplatform has potential for use in targeted tumor imaging and precision therapy.</P>

Weights-adjust Notification Protocol of Cooperative Spectrum Sensing for Ship Ad-hoc Network

Yan Huang,Xin Su,KyungHi Chang 한국통신학회 2013 한국통신학회 학술대회논문집 Vol.2013 No.1

The ship ad-hoc network (SANET) extends the coverage of the high date rate terrestrial communications to the ships with reduced cost in maritime communications. Cognitive radio (CR) technology can help SANET to utilize the spectrum efficiently by exploiting the existing wireless spectrum opportunistically. However, hidden primary node problem decreases the performance of CR-based SANET. In this paper, we compare three traditional cooperative spectrum sensing (CSS) technologies on their performance for solving the hidden primary node problem. And to improve false alarm performance, a weights-adjust notification protocol (WANP) is proposed.

Intrapleural or Intraperitoneal Lobaplatin for Treatment of Patients with Malignant Pleural Effusion or Ascites

Huang, Xin-En,Wei, Guo-Li,Huo, Jie-Ge,Wang, Xiao-Ning,Lu, Yan-Yan,Wu, Xue-Yan,Liu, Jin,Xiang, Jin,Feng, Ji-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Aims: To explore efficacy and side effects of intrapleural or intraperitoneal lobaplatin for treating patients with malignant pleural or peritoneal effusions. Methods: Patients in Jiangsu Cancer Hospital and Research Institute with cytologically confirmed solid tumors complicated with malignant pleural effusion or ascites were enrolled into this study. Lobaplatin (20-30 $mg/m^2$) was intrapleurally or intraperitoneally infused for patients with malignant pleural effusion or ascites. Results: From 2012 to 2013, intrapleural or intraperitonea lobaplatin was administered for patients with colorectal or uterus cancer who were previous treated for malignant pleural effusion or ascites. Partial response was achieved for them. Main side effects were nausea/vomiting, and bone marrow suppression. No treatment related deaths occurred. Conclusion: Intrapleural or intraperitoneal infusion of lobaplatin is a safe treatment for patients with malignant pleural effusion or ascites, and the treatment efficacy is encouraging.

Efficacy and Safety of the Safe Triangular Working Zone Approach in Percutaneous Vertebroplasty for Spinal Metastasis

Yan Bi Cong,Fan Yan Feng,Tian Qing Hua,Wang Tao,Huang Zhi Long,Song Hong Mei,Li Ying,Jiao Lei,Wu Chun Gen 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.9

Objective: This study aimed to assess the technical feasibility, efficacy, and safety of the safe triangular working zone (STWZ) approach applied in percutaneous vertebroplasty (PV) for spinal metastases involving the posterior part of the vertebral body. Materials and Methods: We prospectively enrolled 87 patients who underwent PV for spinal metastasis involving the posterior part of the vertebral body, with or without the STWZ approach, from January 2019 to April 2022. Forty-nine patients (27 females and 22 males; mean age ± standard deviation [SD], 57.2 ± 11.6 years; age range, 31–76 years) were included in group A (with STWZ approach), accounting for 54 vertebrae. Thirty-eight patients (18 females and 20 males; 59.1 ± 10.9 years; 29–81 years) were included in group B (without STWZ approach), accounting for 57 vertebrae. Patient demographics, procedure-related variables, and pain relief as assessed using the visual analog scale (VAS) were collected at different time points. Tumor recurrence in the vertebrae after PV was analyzed using Kaplan–Meier curves. Results: The STWZ approach was successful from T1 to L5 without severe complications. Cement filling was satisfactory in 47/54 (87.0%) and 25/57 (43.9%) vertebrae in groups A and B, respectively (p < 0.001). Cement leakage was not significantly different between groups A and B (p = 1.000). Mean VAS score ± SD before and 1 week and 1, 3, 6, 9, and 12 months after PV were 7.6 ± 1.8, 4.2 ± 2.0, 2.7 ± 1.9, 1.9 ± 1.5, 1.7 ± 1.4, 1.7 ± 1.1, and 1.6 ± 1.3, respectively, in group A and 7.2 ± 1.7, 4.0 ± 1.3, 3.4 ± 1.6, 2.4 ± 1.2, 1.8 ± 1.0, 1.4 ± 0.5, and 1.7 ± 0.9, respectively, in group B. Kaplan–Meier analysis showed a lower tumor recurrence rate in group A than in group B (p = 0.001). Conclusion: The STWZ approach may represent a new, safe, alternative/auxiliary approach to target the posterior part of the vertebral body in the PV for spinal metastases.