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- 저자 : Hu-Nan Piao (검색결과 5 건)
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Xiang Xu,Yu-Nan Lu,Jia-Hui Cheng,Hui-Wen Lan,Jing-Mei Lu,Guang-Nan Jin,Guang-Hua Xu,Cheng-Hua Jin,Juan Ma,Hu-Nan Piao,Xuejun Jin,Lian-Xun Piao 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1
Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kB) signaling pathway. GRh2 also alleviated tumor-associated or lipopolysaccharide-induced depression. However, the effects and potential mechanisms of GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondii infection during pregnancy have not been investigated. Methods: We examined GRh2 effects on the depression-like behavior in mouse offspring, caused by maternal T. gondii infection during pregnancy, by measuring depression-like behaviors and assaying parameters at the neuronal and molecular level. Results: We showed that GRh2 significantly improved behavioral measures: sucrose consumption, forced swim time and tail suspended immobility time of their offspring. These corresponded with increased tissue concentrations of 5-hydroxytryptamine and dopamine, and attenuated indoleamine 2,3-dioxygenase or enhanced tyrosine hydroxylase expression in the prefrontal cortex. GRh2 ameliorated neuronal damage in the prefrontal cortex. Molecular docking results revealed that GRh2 binds strongly to both TLR4 and high mobility group box 1 (HMGB1). Conclusion: This study demonstrated that GRh2 ameliorated the depression-like behavior in mouse offspring of maternal T. gondii infection during pregnancy by attenuating the excessive activation of microglia and neuroinflammation through the HMGB1/TLR4/NF-kB signaling pathway. It suggests that GRh2 could be considered a potential therapy in preventing and treating psychiatric disorders in the offspring mice of mothers with prenatal exposure to T. gondii infection.
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Jeong, Mira,Piao, Zheng-Hao,Kim, Mi Sun,Lee, Suk Hyung,Yun, Sohyun,Sun, Hu-Nan,Yoon, Suk Ran,Chung, Jin Woong,Kim, Tae-Don,Jeon, Jun Ho,Lee, Jiwon,Kim, Hyun-Nam,Choi, Je-Yong,Choi, Inpyo Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.4
<P>Hematopoietic stem cells (HSCs) are maintained in a quiescent state in bone marrow (BM) niches by intrinsic and extrinsic signals. The mechanisms regulating the quiescence and mobilization of HSCs, however, remain unclear. In this study, we report that the expression of thioredoxin-interacting protein (TXNIP) is decreased during HSC activation. In Txnip(-/-) mice, the long-term reconstituting HSC population is decreased and exhausted, and its capacity to repopulate is rapidly lost. These effects are associated with hyperactive Wnt signaling, an active cell cycle, and reduced p21 expression under conditions of stress. TXNIP deficiency reduced the CXCL12- and osteopontin-mediated interaction between HSCs and the bone marrow, and impaired homing and retention in the osteoblastic niche, resulting in mobilized HSCs. Therefore, we propose that TXNIP is essential for maintaining HSC quiescence and the interaction between HSCs and the BM niche.</P>
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Xiang Xu,Lan Jin,Tong Jiang,Ying Lu,Fumie Aosai,Hu-Nan Piao,Guang-Hua Xu,Cheng-Hua Jin,Xue-Jun Jin,Juan Ma,Lian-Xun Piao 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.5
Background: Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarified yet. Methods: The effect of GRh2 against T. gondii was assessed under in vitro and in vivo experiments. The BV2 cells were infected with tachyzoites of T. gondii RH strain, and the effects of GRh2 were evaluated by MTT assay, morphological observations, immunofluorescence staining, a trypan blue exclusion assay, reverse transcription PCR, and Western blot analyses. The in vivo experiment was conducted with BALB/c mice inoculated with lethal amounts of tachyzoites with or without GRh2 treatment. Results and conclusion: The GRh2 treatment significantly inhibited the proliferation of T. gondii under in vitro and in vivo studies. Furthermore, GRh2 blocked the activation of microglia and specifically decreased the release of inflammatory mediators in response to T. gondii infection through TLR4/NF-kB signaling pathway. In mice, GRh2 conferred modest protection from a lethal dose of T. gondii. After the treatment, the proliferation of tachyzoites in the peritoneal cavity of infected mice markedly decreased. Moreover, GRh2 also significantly decreased the T. gondii burden in mouse brain tissues. These findings indicate that GRh2 exhibits an antieT. gondii effect and inhibits the microglial activation through TLR4/NF-kB signaling pathway, providing the basic pharmacological basis for the development of new drugs to treat toxoplasmic encephalitis.
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라포가 고객 행동에 미치는 영향 : 친숙성, 관여도의 조절효과를 중심으로
전성준(Quan, Cheng Jun),강기두(Kang, Gi Du),장은서(Jang, Eun Seo),박호남(Piao, Hu Nan) 글로벌경영학회 2021 글로벌경영학회지 Vol.18 No.1
본 연구는 중국에 있는 하이디라오(海底捞) 훠궈 레스토랑을 방문경험이 있는 사람들을 대상으로 종업원과 고객 간의 라포가 고객행동에 미치는 영향 및 라포에 대한 동일시와 신뢰를 통해 고객들의 행동이 형성되어짐을 실증분석을 통해 검정하고자 하였다. 그리고 라포와 신뢰 및 동일시 간에 어떤 대상에 대해 인지도나 관심도에 따라 차이가 있을 것이라고 예상하며 친숙성, 관여도라는 조절변수를 사용하였다. 총 455부의 설문지를 배포하여 최종분석에 431명의 설문 자료를 SPSS 23.0과 AMOS를 이용하여 분석하였다. 실증분석 결과는 다음과 같다. 첫째, 라포는 동일시와 신뢰에 긍정적인 영향을 미치는 것으로 나타났고, 이어 동일시와 신뢰는 고객참여행동과 고객시민행동에 긍정적인 영향을 미치는 것으로 나타났다. 반면 라포와 고객행동간의 직접적인 관계를 살펴본 결과, 라포는 고객시민행동에는 유의한 영향을 미치지만, 고객참여행동에 미치는 영향은 유의하지 않은 것으로 나타났다. 둘째, 라포와 고객행동간의 관계에서 동일시 및 신뢰의 매개효과를 살펴본 결과, 매개효과를 보여주는 간접 효과가 모두 통계적으로 유의하였다. 마지막으로 친숙성과 관여도의 정도에 따라 라포가 동일시와 신뢰에 미치는 영향이 어떻게 달라지는지를 살펴보았는데 라포와 동일시, 라포와 신뢰의 관계 에서 친숙성 및 관여도에 따른 조절효과가 있는 것으로 나타났다. 본 연구의 검증결과를 토대로 볼 때, 고객이 레스토랑 서비스나 상품을 사용하는 과정에서 종사 원과 즐거운 관계를 유지할 수 있도록 고객의 동일시, 고객신뢰를 파악함을 통해 고객의 자발적 행동을 적극적으로 유도할 수 있다. Rapport is a pleasant interaction between employees and customers; when it is well formed, it can have a positive effect on the customer s behavior and attitude. To this end, companies work hard to improve the satisfactory relationship between employees and customers since it could increase the bond between them. The current study attempted to address the role of rapport in relation with other constructs upon to the literature reviews. Empirical study investing on the customers of restaurant in China and the results are summarized as follows: firstly, rapport exerts a positive correlation on the customer behavior; secondly, identification and trust play a mediating role on the relationship between rapport and customer behavior. Thirdly, familiarity and involvement has the moderating effect on the rapport with identification and trust. Based on such research results, several academic and managerial implications were proposed and at the same time, the limitations for the study were also raised.
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