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김기훈,金虎林,金光華,윤기원,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)
Crushed sand is made by crushing the rock artificially. With the wide shortage of natural fine aggregates at all regions in Korea. crushed sand has been increasingly consumed as a alternative aggreagtes of natural sand. But there is insufficient information related to the actual situation on the produce. quality and manufacturing company of crushed sand. In this paper. survey is performed in order to know actual consumption situation of crushed sand through ready mixed concrete company in domestic. The remicon companies using crushed sand were estimated with 55%. According to the using method of crushed sand. most remicon company used fine aggregates by mixing natural sand and crushed sand. It is found that natural sand is replaced by crushed sand by about 20~50%. For quality problems in using crushed sand. grain shape. grade and fine particles shall be improved to meet the quality requirement of remicon and wide application. Therefore. it is found that quality improvement of crushed sand is required.
Hua Hu,Ruoxun Zhang,Yunwen Wu,Huiqin Ling,Tao Hang,Ming Li 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.1
As the size of interconnect technology in integrated circuits keeps minimizing, the electrical resistivity and signal transmission delay become increasingly serious. The monocrystalline materials can meet the requirements of miniaturization and high-speed interconnection, which is a proper solution of these problems. Hence, we fabricated large monocrystalline Cu cones with (111) orientation using a linear sweep voltammetry electroplating method for the first time. It was found that phosphorus could induce texturization of polycrystals at a certain potential. The grains with uniform orientation grown into single crystals through the oriented attachment growth mechanism. The screw dislocations produced during oriented attachment led to crystal spiral growth, developing into large monocrystalline cones. This work is expected for application in copper interconnect technology in the future.
Hu, Wei-Guo,Hu, Jia-Jia,Cai, Wei,Zheng, Min-Hua,Zang, Lu,Wang, Zheng-Ting,Zhu, Zheng-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
The association between the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene C609T polymorphism (rs1800566) and gastric cancer has been widely evaluated, but a definitive answer is so far lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. Although our case-control association study indicated no significant difference in the genotype and allele distributions of C609T polymorphism between gastric cancer patients and controls, in the meta analysis involving 4,000 subjects, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95%CI) for odds ratio (OR)=1.20-1.79) in individuals with the T allele. The tendency was similar to the homozygote (OR=1.81, 95%CI: 1.16-2.84), dominant models (OR=1.41, 95%CI: 1.12-1.79), as well as recessive model (OR=1.58, 95%CI: 1.06-2.35). Stratified analysis by study design demonstrated stronger associations in population-based than in hospital-based studies. And ethnicity-based analysis demonstrated a significant association in Asians. We conclude that the NQO1 gene C609T polymorphism increases the risk for gastric cancer, especially in Asian populations.
A CLASS OF INVERSE CURVATURE FLOWS IN ℝ<sup>n+1</sup>, II
Hu, Jin-Hua,Mao, Jing,Tu, Qiang,Wu, Di Korean Mathematical Society 2020 대한수학회지 Vol.57 No.5
We consider closed, star-shaped, admissible hypersurfaces in ℝ<sup>n+1</sup> expanding along the flow Ẋ = |X|<sup>α-1</sup> F<sup>-β</sup>, α ≤ 1, β > 0, and prove that for the case α ≤ 1, β > 0, α + β ≤ 2, this evolution exists for all the time and the evolving hypersurfaces converge smoothly to a round sphere after rescaling. Besides, for the case α ≤ 1, α + β > 2, if furthermore the initial closed hypersurface is strictly convex, then the strict convexity is preserved during the evolution process and the flow blows up at finite time.
Hu, Hua-Bin,Kuang, Lei,Zeng, Xiao-Min,Li, Bin,Liu, En-Yi,Zhong, Mei-Zuo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Purpose: The relationship between thymidylate synthase (TS) expression and outcomes in gastric cancer (GC) patients remains controversial, although most studies reported poor survival and reduced response to fluoropyrimidine were related to high TS in tumors. We carried out a systematic review of the literature with meta-analysis to estimate the predictive value of TS expression from published studies. Methods: We indentified 24 studies analysing the outcome data in gastric cancer stratified by TS expression. Effect measures of outcome were hazard ratios (HRs) for overall survival (OS) and event-free survival (EFS), or the odds ratio (OR) for overall response rate (ORR). HRs and ORs from these eligible studies were pooled using random-effects meta-analysis. Results: Fifteen studies investigated outcomes in a total of 844 patients with advanced GC, and nine studies investigated outcomes in a total of 1,235 patients with localized GC undergoing adjuvant therapy. Meta-analysis of estimates showed high TS expression was significantly associated with poor OS in the advanced setting (HR: 1.43, 95%CI: 1.08 - 1.90), and poor EFS in the adjuvant setting (HR: 1.53, 95%CI: 1.01 - 2.32). Subgroup analysis demonstrated TS expression to haves even greater value in predicting OS, EFS and ORR in advanced GC patients treated with fluoropyrimidine monotherapy (HR for OS: 2.32, 95%CI: 1.53 - 3.50; HR for EFS: 1.76, 95%CI: 1.19 - 2.60; OR for ORR: 0.32, 95%CI: 0.11 - 0.95). Conclusion: High levels of TS expression were asssociated with a poorer OS for advanced GC patients compared with low levels. In the adjuvant setting, high TS expression was also associated with a worse EFS. Additional studies with consistent methodology are needed to define the precise predictive value of TS.
Hu, Dong,Ran, Yu-Liang,Zhong, Xing,Hu, Hai,Yu, Long,Lou, Jin-Ning,Sun, Li-Xing,Yang, Zhi-Hua Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.6
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be targeted for refolding or degradation to maintain the homeostasis of the ER. Derlin-1 was reportedly implicated in the retro-translocation of misfolded proteins from the ER to the cytosol for degradation. In this report, we showed that Derlin-1 was down-regulated in the endothelial cells derived from human hepatic cavernous hemangioma (CHEC) compared with other tested cells. Electron microscopy analysis showed that ER was aberrantly enlarged in CHEC cells, but not in other tested cells. When overexpressed, Derlin-1 induced the dilated ER to return normal size. This ER dynamic was associated with the activation of unfolded protein response (UPR). In CHEC cells where Derlin-1 was down-regulated, increased expression of the immunoglobulin heavy chain-binding protein (Bip) and UPR-specific splicing of X-box DNA-binding protein 1 (XBP1) mRNA were detected, as compared with that in other tested cells, indicating that UPR was activated. After Derlin-1 overexpression, the extent of UPR activation diminished, as evidenced by decreased expression of Bip, reduced amount of the spliced form of XBP1 ($XBP1_S$), and elevated expression of the unspliced form of XBP1 ($XBP1_U$). Taken together, these findings provide another example of a single protein being able to affect ER dynamic in mammalian cells, and an insight into the possible molecular mechanism(s).
( Hua Qi Pan ),( Su Ya Yu ),( Chun Feng Song ),( Nan Wang ),( Hui Ming Hua ),( Jiang Chun Hu ),( Shu Jin Wang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.3
A new actinomycete strain NA4 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antifungal activities against soilborne fungal pathogens. It was identified as Streptomyces cavourensis by morphological, physiological, and phylogenetic analyses based on its 16S rRNA gene sequence. The main antifungal components were isolated and identified from the fermentation culture as bafilomycins B1 and C1. These compounds exhibited significant antifungal activities and a broad antifungal spectrum. The results suggest that the Streptomyces cavourensis NA4 and bafilomycins B1 and C1 could be used as potential biocontrol agents for soilborne fungal diseases of plants.
Haiyang Hu,Hua Hu,Jie Chen 보안공학연구지원센터 2008 International Journal of Hybrid Information Techno Vol.1 No.1
Because of the limited capability of mobile devices and lower bandwidth of wireless network, Web-based e-commerce in mobile wireless environments suffers more challenges and it needs an efficient and reliable mechanism to support the process. This paper presents a flexible and configurable mechanism, which uses mobile agents as brokers of mobile device to communicate with Web server, thus to reduce the unnecessary wireless communication costs of mobile client. It can also facilitate mobile device recovery back when suffering a failure to increase the reliability of the whole application process. Compared with other mechanisms through performance analysis, our mechanism shows its efficiency and reliability.
Qiu-Hua Wang,Na Kuang,Wen-yue Hu,Dan Yin,Ying-Yi Wei,Ting-Jun Hu 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.4
Background: Panax notoginseng saponins (PNS) are bioactive substances extracted from P. notoginseng that are widely used to treat cardiovascular and cerebrovascular diseases and interstitial diseases. PNS have the functions of scavenging free radicals, anti-inflammation, improving blood supply for tissue and so on. Objectives: The aim of this study was to investigate the effects of PNS on the oxidative stress of immune cells induced by porcine circovirus 2 (PCV2) infection in vitro and in vivo. Methods: Using an oxidative stress model of PCV2 infection in a porcine lung cell line (3D4/2 cells) and mice, the levels of nitric oxide (NO), reactive oxygen species (ROS), total glutathione (T-GSH), reduced glutathione (GSH), and oxidized glutathione (GSSG) and the activities of xanthine oxidase (XOD), myeloperoxidase (MPO) and inducible nitric oxide synthetase (iNOS) were determined to evaluate the regulatory effects of PNS on oxidative stress. Results: PNS treatment significantly reduced the levels of NO and ROS, the content of GSSG and the activities of XOD, MPO, and iNOS (p < 0.05), while significantly increasing GSH and the ratio of GSH/GSSG in infected 3D4/2 cells (p < 0.05).Similarly, in the in vivo study, PNS treatment significantly decreased the level of ROS in spleen lymphocytes of infected mice (p < 0.05), increased the levels of GSH and T-GSH (p < 0.05), significantly decreased the GSSG level (p < 0.05), and decreased the activities of XOD, MPO, and iNOS. Conclusions: PNS could regulate the oxidative stress of immune cells induced by PCV2 infection in vitro and in vivo.