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- 저자 : Hsin-I Chiang (검색결과 4 건)
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Yuan-Hao Chen,Yung-Hsiao Chiang,Hsin-I Ma 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.2
Background and Purpose Hypoxia, or ischemia, is a common cause of neurological deficits in the elderly. This study elucidated the mechanisms underlying ischemia-induced brain injury that results in neurological sequelae. Methods Cerebral ischemia was induced in male Sprague-Dawley rats by transient ligationof the left carotid artery followed by 60 min of hypoxia. A two-dimensional differential proteome analysis was performed using matrix-assisted laser desorption ionization-time-of-flightmass spectrometry to compare changes in protein expression on the lesioned side of the cortexrelative to that on the contralateral side at 0, 6, and 24 h after ischemia. Results The expressions of the following five proteins were up-regulated in the ipsilateralcortex at 24 h after ischemia-reperfusion injury compared to the contralateral (i.e., control)side: aconitase 2, neurotensin-related peptide, hypothetical protein XP-212759, 60-kDa heatshock protein, and aldolase A. The expression of one protein, dynamin-1, was up-regulatedonly at the 6-h time point. The level of 78-kDa glucose-regulated protein precursor on the lesioned side of the cerebral cortex was found to be high initially, but then down-regulated by 24 hafter the induction of ischemia-reperfusion injury. The expressions of several metabolic enzymes and translational factors were also perturbed soon after brain ischemia. Conclusions These findings provide insights into the mechanisms underlying the neurodegenerative events that occur following cerebral ischemia.
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Ting-I Chiang,Yi-Hsiang Yu,Chieh-Hsin Lin,Hsien-Yuan Lane 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3
Early detection and prevention of Alzheimer’s disease (AD) is important. The current treatment for early AD is acetylcholine esterase inhibitors (AChEIs); however, the efficacy is poor. Besides, AChEI did not show efficacy in mild cognitive impairment (MCI). Beta-amyloid (A) deposits have been regarded to be highly related to the pathogenesis of AD. However, many clinical trials aiming at the clearance of A deposits failed to improve the cognitive decline of AD, even at its early phase. There should be other important mechanisms unproven in the course of AD and MCI. Feasible biomarkers for the diagnosis and treatment response of AD are lacking to date. The N-methyl-D-aspartate receptor (NMDAR) activation plays an important role in learning and memory. On the other hand, oxidative stress has been regarded to contribute to aging with the assumption that free radicals damage cell constituents and connective tissues. Our recent study found that an NMDAR enhancer, sodium benzoate (the pivotal inhibitor of D-amino acid oxidase [DAAO]), improved the cognitive and global function of patients with early-phase AD. Further, we found that peripheral DAAO levels were higher in patients with MCI and AD than healthy controls. We also found that sodium benzoate was able to change the activity of antioxidant. These pieces of evidence suggest that the NMDAR function is associated with anti-oxidation, and have potential to be biomarkers for the diagnosis and treatment response of AD.
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Chin-Cheng Lin,Pin-Chi Tang,Hsin-I Chiang 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.6
Incidents of food fraud have occurred worldwide,particularly in the form of meat adulteration. In thisstudy, molecular probes were developed using the Randomamplification of polymorphic DNA (RAPD) polymerasechain reaction (PCR) technique in order to identify threebeef subspecies–Holstein, Angus, and Taiwan YellowCattle. Four RAPD-PCR 10-nucleotide primers were chosenout of a total of 60 primers. The selection was based onthe reproducibility of species-specific amplicons able todetect various origins of cattle breeds. The resultsdemonstrated that primer OPK12 produced three uniqueamplicons (1100 bp, 1000 bp and 480 bp) in Holstein;primer OPK14 generated one amplicon that only appearedin Holstein and Angus (200 bp); primer OPK19 amplifiedtwo species-specific amplicons in Holstein measuring550 bp and 650 bp, respectively. However, due to therelatively lower repeatability of RAPD-PCR, higher andmore specific testing repeats were required to increase theaccuracy of the conclusion.
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Liu, Wen-Bor,Peh, Huo-Cheng,Wang, Chien-Kai,Mangwe, Mancoba Christopher,Chen, Chih-Feng,Chiang, Hsin-I Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.6
Objective: The purpose of this retrospective study was to investigate the relationship between temperature-humidity index (THI), season, and conception rate (CR) of Holstein cows in central Taiwan. Methods: The mean performance and number of observations were statistically evaluated for various parameters, including age at first service, number of days open, gestation length, CR, and calving interval for different parities. Results: The results indicate that the mean age at first service was 493.2 days; the gestation length was similar across all cows of different parities, ranging from 275.1 to 280.7 days. The overall CR of all inseminations was significantly lower in multiparous cows ($47.26%{\pm}0.22%$) than in heifers ($57.14%{\pm}0.11%$) (p<0.05). At THI>72 and during the hot season (from June to November), CRs for multiparous cows were significantly reduced compared to that for heifers, while the ratio remained unchanged among heifers for all seasons. Conclusion: To achieve a high CR, lactating cows should be bred in winter and spring (from December to May) from the start of the seasonal breeding program, whereas the heifer should be allowed to breed in summer and fall under the subtropical climate in Taiwan.
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