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Hongyan Lin,Fangfang Sui,Peng Liu,Xiu-Li Wang,Guo-Cheng Liu 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.7
Two new 3D coordination complexes [Cd(3-bpcd)(pht)] (1) and [Zn(3-bpcd)(pht)] (2) [3-bpcd = N,N'-bis(pyridin- 3-yl)cyclohexane-1,4-dicarboxamide, H2pht = phthalic acid] have been hydrothermally synthesized. X-ray diffraction analysis reveals that the complexes 1 and 2 represent a 4-connected diamondoid topology with a 3- fold interpenetrating feature. Moreover, the fluorescent properties of complexes 1 and 2 are studied.
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Design and Realization of Smart Home Terminal Applications Based on IOT Technology
Liu Hongyan 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.8
With the development of IoT technology, more and more smart household devices, such as sensors and smart mobile terminals, have appeared in our daily life. Users can remotely control almost all the devices in the smart home system and understand their information, thus effectively improving the user life quality. For background, this paper designs and develops two smart mobile terminal applications based on smart home technologies research: one is the smart remote control application based on infrared technology, which realizes remote controlling on infrared smart devices based on infrared transmission technology, Wi-Fi and Socket technology; the other is remote control and monitor application based on PhoneGap, which realizes remote controlling and monitoring on the devices directly connected to the gateway based on PhoneGap, HTTP request and HTML5 cache technology. Research on the mobile applications in the smart home system and their realization laid a solid foundation for the future research and function expansion of smart home and even smart city system.
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The Cloud Management System Based on Micro Station Cell Energy Management
Liu Hongyan 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.1
In cellular networks, as a result of the heterogeneous network layout, a number of community, in the entire network, micro base station district energy management issues that need to be unified management and scheduling, and combined with the flow of communication and transport business and the efficiency of energy management, the development of energy management system based on cloud computing platform, according to the system, can have better energy efficiency, realize the communication and the advantage of energy balance. This article mainly from the two aspects of theory and actual implementation of this management system research.
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Liu Xiaoyi,Wei Qinglv,Yang Chenyue,Zhao Hongyan,Xu Jie,Mobet Youchaou,Luo Qingya,Yang Dan,Zuo Xinzhao,Chen Ningxuan,Yang Yu,Li Li,Wang Wei,Yu Jianhua,Xu Jing,Liu Tao,Yi Ping 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional regulation, in ovarian cancer, is poorly understood. In this study, we revealed that the RNA methyltransferase NSUN2 facilitates mRNA m5C modification and forms a positive feedback regulatory loop with the transcription factor E2F1 in ovarian cancer. Specifically, NSUN2 promotes m5C modification of E2F1 mRNA and increases its stability, and E2F1 binds to the NSUN2 promoter, subsequently reciprocally activating NSUN2 transcription. The RNA binding protein YBX1 functions as the m5C reader and is involved in NSUN2-mediated E2F1 regulation. m5C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the expression of the oncogenes MYBL2 and RAD54L, driving ovarian cancer progression. Thus, our study delineates a NSUN2-E2F1-NSUN2 loop regulated by m5C modification in a manner dependent on YBX1 phase separation, and this previously unidentified pathway could be a promising target for ovarian cancer treatment.
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Cuihua Liu,Hongyan Zhang,Zhaoyi Dai,Xi Liu,Yue Liu,Xiuxin Deng,Feng Chen,Juan Xu 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.2
Twelve watermelon [Citrullus vulgaris (Thunb.)Schrad (Cucurbitaceae)] cultivars with different flesh colors were analyzed by HPLC, GC-FID, and GC-MS for their differences in carotenoid, soluble sugar, organic acid,and flavor. Results showed that all-trans violaxanthin, 9-cis-violaxanthin, and luteoxanthin were the main carotenoid esters in watermelons with yellow flesh. However,watermelons with red flesh were rich in all-trans lycopene and their cis-isomers. High concentrations of β-carotene and pro-lycopenes were found in watermelon with orangeyellow flesh. Large variations in the sucrose concentration were observed among the different watermelons. Sucrose and/or fructose were the dominant sugars, while citric acid and malic acid were the main organic acids in watermelon flesh. Limonene was detected in the watermelon flesh of all investigated genotypes. Interestingly, partial correlation analysis of the chemical concentrations revealed 2 significant (p<0.01) positive correlations between β-ionone and β-carotene, and between (E)-geranyl acetone and prolycopenes
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Research on data augmentation algorithm for time series based on deep learning
Shiyu Liu,Hongyan Qiao,Lianhong Yuan,Yuan Yuan,Jun Liu 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.6
Data monitoring is an important foundation of modern science. In most cases, the monitoring data is time-series data, which has high application value. The deep learning algorithm has a strong nonlinear fitting capability, which enables the recognition of time series by capturing anomalous information in time series. At present, the research of time series recognition based on deep learning is especially important for data monitoring. Deep learning algorithms require a large amount of data for training. However, abnormal sample is a small sample in time series, which means the number of abnormal time series can seriously affect the accuracy of recognition algorithm because of class imbalance. In order to increase the number of abnormal sample, a data augmentation method called GANBATS (GAN-based Bi-LSTM and Attention for Time Series) is proposed. In GANBATS, Bi-LSTM is introduced to extract the timing features and then transfer features to the generator network of GANBATS.GANBATS also modifies the discriminator network by adding an attention mechanism to achieve global attention for time series. At the end of discriminator, GANBATS is adding averagepooling layer, which merges temporal features to boost the operational efficiency. In this paper, four time series datasets and five data augmentation algorithms are used for comparison experiments. The generated data are measured by PRD(Percent Root Mean Square Difference) and DTW(Dynamic Time Warping). The experimental results show that GANBATS reduces up to 26.22 in PRD metric and 9.45 in DTW metric. In addition, this paper uses different algorithms to reconstruct the datasets and compare them by classification accuracy. The classification accuracy is improved by 6.44%-12.96% on four time series datasets.
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Mei Liu,Yichun Wang,Mengting Li,Hongyan Feng,Qingyao Liu,Chunxia Qin,Yongxue Zhang,Xiaoli Lan 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The study aimed to investigate the feasibility of noninvasive monitoring of bone marrow mesenchymal stem cells (MSCs) transduced with the tyrosinase reporter gene for acute myocardial infarction (AMI) with photoacoustic imaging (PAI), magnetic resonance imaging (MRI), and positron emission tomography (PET) in vitro and in vivo. MSCs were transduced with a lentivirus carrying a tyrosinase reporter gene. After transduction, the rate of 18F-5-fluoro-N-(2- [diethylamino]ethyl)picolinamide (18F-5-FPN) uptake was measured. PAI and MRI of stable cell lines expressing tyrosinase (TYR-MSCs) were performed in vitro. An AMI model was induced and verified. TYR-MSCs and MSCs were injected into the margins of the infarcted areas, and PAI, MRI, and PET images were acquired 1, 7, 14, 21, and 28 days after cell injection. Sham-operated models without injection were used as the control group. TYR-MSCs showed noticeably higher uptake of 18F-5-FPN and stronger signals in T1-weighted MRI and PAI than non-transduced MSCs. In vivo studies revealed prominent signals in the injected area of the infarcted myocardium on PAI/MRI/PET images, whereas no signal could be seen in rats injected with non-transduced MSCs or sham-operated rats. The uptake values of 18F-5-FPN in vivo showed a slight decrease over 28 days, whereas MRI and PAI signal intensity decreased dramatically. MSCs stably transduced with the tyrosinase reporter gene could be monitored in vivo in myocardial infarction models by PET, MRI, and PAI, providing a feasible and reliable method for checking the viability, location, and dwell time of transplanted stem cells.
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Lin, Hongyan,Sui, Fangfang,Liu, Peng,Wang, Xiuli,Liu, Guocheng Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.7
Two new 3D coordination complexes [Cd(3-bpcd)(pht)] (1) and [Zn(3-bpcd)(pht)] (2) [3-bpcd = N,N'-bis(pyridin-3-yl)cyclohexane-1,4-dicarboxamide, $H_2pht$ = phthalic acid] have been hydrothermally synthesized. X-ray diffraction analysis reveals that the complexes 1 and 2 represent a 4-connected diamondoid topology with a 3-fold interpenetrating feature. Moreover, the fluorescent properties of complexes 1 and 2 are studied.
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Ting Deng,Kaijiang Liu,Liang Chen,Xiao-jun Chen,Hua Wen Li,Hongyan Guo,Huijiao Zhang,Libing Xiang,Xin Feng,Xiaoyu Wang,Hextan Y. S. Ngan,Jianguo Zhao,Dongling Zou,Qing Liu,Jihong Liu 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3
Background: The Lymphadenectomy in Ovarian Neoplasms (LION) study revealed that systemic lymphadenectomy did not bring survival benefit for advanced ovarian cancer patients with clinically normal lymph nodes and was associated with a higher incidence of operative complications. However, there is no consensus on whether lymphadenectomy has survival benefit or not in early epithelial ovarian cancer (EOC). Methods: We designed the LOVE study, a multicenter, randomized controlled, phase III trial to compare the efficacy and safety of comprehensive staging surgery with or without lymphadenectomy in stages IA-IIB EOC and fallopian tube carcinomas (FTC). The hypothesis is that the oncological outcomes provided by comprehensive staging surgery without lymphadenectomy are non-inferior to those of conventional completion staging surgery in early-stage EOC and FTC patients who have indications for post-operative adjuvant chemotherapy. Patients assigned to experimental group will undergo comprehensive staging surgery, but lymphadenectomy. Patients assigned to comparative group will undergo completion staging surgery including systematic pelvic and para-aortic lymphadenectomy. All subjects will receive 3–6 cycles of standard adjuvant chemotherapy. Major inclusion criteria are pathologic confirmed stage IA-IIB EOC or FTC, and patients have indications for adjuvant chemotherapy either confirmed by intraoperative fast frozen section or previous pathology after an incomplete staging surgery. Major exclusion criteria are non-epithelial tumors and low-grade serous carcinoma. Patients with severe rectum involvement which lead to partial rectum resection will be excluded. The sample size is 656 subjects. Primary endpoint is disease-free survival.
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