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Honglin Xu,Haifeng Miao,Guanghong Chen,Guoyong Zhang,Yue Hua,Yuting Wu,Tong Xu,Changlei Hu,Mingjie Pang,Leyi Tan,Xin Han,Bin Liu,Yingchun Zhou 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6
Background: Myocardial fibrosis post-myocardial infarction (MI) can induce maladaptive cardiacremodeling as well as heart failure. Although 20(S)-ginsenoside Rg3 (Rg3) has been applied to cardiovasculardiseases, its efficacy and specific molecular mechanism in myocardial fibrosis are largely unknown. Herein, we aimed to explore whether TGFBR1 signaling was involved in Rg3's anti-fibrotic effectpost-MI. Methods: Left anterior descending (LAD) coronary artery ligation-induced MI mice and TGF-b1-stimulated primary cardiac fibroblasts (CFs) were adopted. Echocardiography, hematoxlin-eosin andMasson staining, Western-blot and immunohistochemistry, CCK8 and Edu were used to study the effectsof Rg3 on myocardial fibrosis and TGFBR1 signaling. The combination mechanism of Rg3 and TGFBR1 wasexplored by surface plasmon resonance imaging (SPRi). Moreover, myocardial Tgfbr1-deficient mice andTGFBR1 adenovirus were adopted to confirm the pharmacological mechanism of Rg3. Results: In vivo experiments, Rg3 ameliorated myocardial fibrosis and hypertrophy and enhanced cardiacfunction. Rg3-TGFBR1 had the 1.78 10 7 M equilibrium dissociation constant based on SPRi analysis,and Rg3 inhibited the activation of TGFBR1/Smads signaling dose-dependently. Cardiac-specific Tgfbr1knockdown abolished Rg3's protection against myocardial fibrosis post-MI. In addition, Rg3 downregulatedthe TGF-b1-mediated CFs growth together with collagen production in vitro through TGFBR1signaling. Moreover, TGFBR1 adenovirus partially blocked the inhibitory effect of Rg3. Conclusion: Rg3 improves myocardial fibrosis and cardiac function through suppressing CFs proliferationalong with collagen deposition by inactivation of TGFBR1 pathway.
Double-Matching Resource Allocation Strategy in Fog Computing Networks Based on Cost Efficiency
Jia, Boqi,Hu, Honglin,Zeng, Yu,Xu, Tianheng,Yang, Yang The Korean Institute of Communications and Informa 2018 Journal of communications and networks Vol.20 No.3
Fog computing is an advanced technique to decrease latency and network congestion, and provide economical gains for Internet of Things (IoT) networks. In this paper, we investigate the computing resource allocation problem in three-layer fog computing networks. We first formulated the resource allocation problem as a double two-sided matching optimization problem. Then, we propose a double-matching strategy for the resource allocation problem in fog computing networks based on cost efficiency, which is derived by analysing the utility and cost in fog computing networks. The proposed double-matching strategy is an extension of the deferred acceptance algorithm from two-side matching to three-side matching. Numerical results show that high cost efficiency performance can be achieved by adopting the proposed strategy. Furthermore, by using the proposed strategy, the three participants in the fog computing networks could achieve stable results that each participant cannot change its paired partner unilaterally for more cost efficiency.
In silico Discovery of Genes Expressed in Liver, Kidney, Spleen and Small Intestine of Pigs
Pan, Zengxiang,Liu, Honglin,Chen, Jie,Xu, Dan,Jiang, Zhihua,Xie, Zhuang Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.2
An in silico approach was developed to survey the genes expressed in four internal organs of pig: liver, kidney, spleen and small intestine. The major procedures of the approach included: (1) BLAST searching against GenBank "est_others" database using human cDNA sequences as queries to screen the porcine orthologous expressed sequence tags (ESTs), (2) classifying the porcine ESTs records by resources according to certain criteria and (3) analyzing data for ESTs specifically expressed in each organ. In order to do so, four Java programs were developed. Based on the ESTs available in the GenBank database, it was found that there were at least 2,100 genes expressed in these four organs, including 128 in the liver, 81 in the kidney, 780 in the spleen, and 1,423 in the small intestine respectively (a few genes co-expressed in these tissues). Gene expression patterns, such as co-expressed genes, preferentially expressed genes and basic active genes were also compared and characterized among these organs. This study provides a comprehensive model on how to use the bioinformatics approach and Genbank databases to facilitate the discovery of new genes in livestock species.
Chuan Li,Xinxin Wang,Qiangqiang Zhang,Xu Tan,Yefeng Liu,Honglin Li,Hao Liu,Enzhu Hu,Xianguo Hu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-
This study fabricated nano-CeO2/biodiesel carbon soot (BCS) composites using the raw material BCS,which is the byproduct of biodiesel combustion and cerium salt and used as a novel lubricant additiveto PAO6 for steel/steel contact. Oleylamine modified nano-CeO2/BCS composites comprise abundant lipophilicgroups, and thus nano-CeO2/BCS composites exhibit good dispersion in PAO6. The tribologicalresults showed that nano-CeO2/BCS composites significantly improved the lubricating performances ofPAO6. In case of 0.1 wt% nano-CeO2/BCS composites dispersed in PAO6, the friction coefficient and wearvolume were reduced by 17.3 and 35.2%, respectively. The improved tribological properties were attributedto the composites rolling and forming of a lubricating film on the friction surface and the presence ofBCS and CeO2 in composites exerting a synergistic lubricating effect, which simultaneously improved thetribological properties of PAO6. This discovery contributes to the conversion of BCS into valuables andpromotes the high value utilization of BCS as a lubricating additive.