A Comparison of Transradial and Transfemoral Percutaneous Coronary Intervention in Chinese Women Based on a Propensity Score Analysis

Yi Xu,Chen Jin,Shubin Qiao,Yongjian Wu,Hongbing Yan,Kefei Dou,Bo Xu,Jingang Yang,Yuejin Yang 대한심장학회 2018 Korean Circulation Journal Vol.48 No.8

Background and Objectives: Over the past decades, transradial approach for percutaneous coronary intervention (PCI) has been increasingly adopted in clinical practice. Women represent a large population who will possibly benefit from PCI, but they are often under-represented in clinical studies. Therefore, the role of TRI in women remains to be further defined. This study sought to compare safety and efficacy for transradial intervention (TRI) and transfemoral intervention (TFI) in women undergoing PCI in China. Methods: The study population consisted of 5,067 women undergoing PCI at Fuwai Hospital, Beijing, China between 2006 and 2011 (TRI: n=4,105, TFI: n=962). Incidence rates of clinical outcomes during hospitalization and at 1-year follow-up were compared between TRI and TFI. In order to minimize potential biases, a 1:1 propensity score matching (PSM) was performed. A total of 899 pairs were matched. Results: Baseline and procedural characteristics were well-balanced between TRI and TFI groups after controlling for confounders using PSM. TRI was associated with reduced major post-PCI bleeding (odds ratio [OR], 0.64; 95% confidence interval [CI], 0.54–0.76; p<0.001) and access site complications (OR, 0.67; 95% CI, 0.61–0.74; p<0.001) after PSM. There was no statistical differences in the incidence rates of major adverse cardiac events (a composite of cardiac death, myocardial infarction, and target vessel revascularization) both during hospitalization and at 1-year follow-up (p>0.05). Conclusions: In this propensity score-based analysis of TRI versus TFI in Chinese women, TRI showed advantages of safety and feasibility over TFI. A wider adoption of TRI in women has the potential to improve outcomes in treatment of coronary artery diseases.

Wave propagation simulation and its wavelet package analysis for debonding detection of circular CFST members

Bin Xu,Hongbing Chen,Song Xia 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.2

In order to investigate the interface debonding defects detection mechanism between steel tube and concrete core of concrete-filled steel tubes (CFSTs), multi-physical fields coupling finite element models constituted of a surface mounted Piezoceramic Lead Zirconate Titanate (PZT) actuator, an embedded PZT sensor and a circular cross section of CFST column are established. The stress wave initiation and propagation induced by the PZT actuator under sinusoidal and sweep frequency excitations are simulated with a two dimensional (2D) plain strain analysis and the difference of stress wave fields close to the interface debonding defect and within the cross section of the CFST members without and with debonding defects are compared in time domain. The linearity and stability of the embedded PZT response under sinusoidal signals with different frequencies and amplitudes are validated. The relationship between the amplitudes of stress wave and the measurement distances in a healthy CFST cross section is also studied. Meanwhile, the responses of PZT sensor under both sinusoidal and sweep frequency excitations are compared and the influence of debonding defect depth and length on the output voltage is also illustrated. The results show the output voltage signal amplitude and head wave arriving time are affected significantly by debonding defects. Moreover, the measurement of PZT sensor is sensitive to the initiation of interface debonding defects. Furthermore, wavelet packet analysis on the voltage signal under sweep frequency excitations is carried out and a normalized wavelet packet energy index (NWPEI) is defined to identify the interfacial debonding. The value of NWPEI attenuates with the increase in the dimension of debonding defects. The results help understand the debonding defects detection mechanism for circular CFST members with PZT technique.

Permanent Magnet Synchronous Motor Control Algorithm Based on Stability Margin and Lyapunov Stability Analysis

Hongyu Jie,Hongbing Xu,Yanbing Zheng,Xiaoshuai Xin,Gang Zheng 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.6

The permanent magnet synchronous motor (PMSM) is widely used in various fields and the proportional-integral (PI) controller is popular in PMSM control systems. However, the motor parameters are usually unknown, which can lead to a complicated PI controller design and poor performance. In order to design a PI controller with good performance when the motor parameters are unknown, a control algorithm based on stability margin is proposed in this paper. First of all, based on the mathematical model of the PMSM and the least squares (LS) method, motor parameters are estimated offline. Then based on the estimation values of the motor parameters, natural angular frequency and phase margin, a PI controller is designed. Performance indices including the natural angular frequency and the phase margin are used directly to design the PI controller in this paper. Scalar functions of the d-loop and the q-loop are selected. It can be seen that the designed controller parameters satisfy Lyapunov large scale asymptotic stability theory if the natural angular frequencies of the d-loop and the q-loop are large than 0. Experimental results show that the parameter estimation method has good accuracy and the designed PI controller proposed in this paper has good static and dynamic performances.

Permanent Magnet Synchronous Motor Control Algorithm Based on Stability Margin and Lyapunov Stability Analysis

Jie, Hongyu,Xu, Hongbing,Zheng, Yanbing,Xin, Xiaoshuai,Zheng, Gang The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.6

The permanent magnet synchronous motor (PMSM) is widely used in various fields and the proportional-integral (PI) controller is popular in PMSM control systems. However, the motor parameters are usually unknown, which can lead to a complicated PI controller design and poor performance. In order to design a PI controller with good performance when the motor parameters are unknown, a control algorithm based on stability margin is proposed in this paper. First of all, based on the mathematical model of the PMSM and the least squares (LS) method, motor parameters are estimated offline. Then based on the estimation values of the motor parameters, natural angular frequency and phase margin, a PI controller is designed. Performance indices including the natural angular frequency and the phase margin are used directly to design the PI controller in this paper. Scalar functions of the d-loop and the q-loop are selected. It can be seen that the designed controller parameters satisfy Lyapunov large scale asymptotic stability theory if the natural angular frequencies of the d-loop and the q-loop are large than 0. Experimental results show that the parameter estimation method has good accuracy and the designed PI controller proposed in this paper has good static and dynamic performances.

Oxygen vacancies – Cu doping junction control of d-Bi2O3 nanosheets for enhanced photocatalytic nitrogen fixation

Xiaoming Gao,Kaixuan Xu,Hongbing He,Shouda Liu,Xiangbo Zhao 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-

Cu-d-Bi2O3 nanosheets with uniform thickness of approximately 2.7 nm and length about 200 nm forphotocatalytic nitrogen fixation and photocatalytic oxidation is achieved by simple hydrothermalmethod. The 2D ultrathin structure is benefit to the formation of the surface oxygen vacancies, meanwhilethe impurity defect is formed due to the substitutive Cu doping of d-Bi2O3. The as-prepared 5%Cu-d-Bi2O3 exhibits excellent NH4 + generation rate of 142.8 lmol h1 g1 without any sacrificial agentirradiated by visible light. The remarkable photocatalytic ability can be attributed to the ultrafast carrierstransfer from the interior to the surface because of 2D ultrathin structure feature, the separation ofelectrons-holes and molecular chemisorption due to the formation of surface oxygen vacancies andimpurity defect.

Sampled-data Output Feedback Control of a Class of Uncertain Nonlinear Systems

Jian Zhang,Xiaoshuai Xin,Hongbing Xu 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.1

In this paper, we study the problem of sampled-data output feedback control for a class of uncertain nonlinear systems. The main contributions of this work are two-fold: (i) we develop a systematic design procedure of sampled-data output feedback controller; and (ii) we provide a theoretical analysis of the sampled-data closed-loop system, which shows that the state of the plant can be regu-lated into any given neighborhood of the origin by an appropriate choice of design parameters and sampling period. Furthermore, the bound of the neighborhood is proportionally dependent on the sam-pling period. Finally, an illustrative example is given to demonstrate the effectiveness of the presented method.

Genetic variations in DROSHA and DICER and survival of advanced non-small cell lung cancer: a two-stage study in Chinese population

Shuangshuang Wu,Yun Pan,Songyu Cao,Jiali Xu,Yan Liang,Yan Wang,Lei Chen,Yunyan Wei,Chongqi Sun,Weihong Zhao,Zhibin Hu,Hongxia Ma,Hongbing Shen,Jianqing Wu 한국유전학회 2015 Genes & Genomics Vol.37 No.7

MicroRNAs (miRNA) are a class of small, noncoding RNA molecules involved in carcinogenesis. Genetic variations in miRNA processing genes may affect the biogenesis of miRNAs, and consequently affect miRNAs regulation and development and progression of human cancer. Therefore, we hypothesized that polymorphisms in two main miRNA biosynthesis genes (DROSHA and DICER) may modulate the survival of advanced non-small cell lung cancer (NSCLC) patients in China. We selected 36 common tagging SNPs in DROSHA and DICER and evaluated the associations of these SNPs with survival of advanced NSCLC patients by a two-stage study in Chinese Han population (discovery cohort: 303 patients; replication cohort: 340 patients). Thirty-six SNPs were detected in the discovery cohort and 12 promising SNPs were validated in the replication cohort. The results showed that DROSHA rs3805525 was marginally associated with the survival of NSCLC patients in the replication cohort (dominant model: HR 0.69, 95 % CI 0.46–1.03, P = 0.071), which was in the same direction as that in the discovery cohort. When combing all patients into one group, three SNPs (rs3805525, rs17410035 and rs7719497) in DROSHA showed significantly associations with NSCLC survival (additive model: HR 0.82, 95 % CI 0.68–0.99 for rs3805525; HR 0.79, 95 % CI 0.62–1.00 for rs17410035; HR 0.76, 95 % CI 0.62–0.93 for rs7719497). Additionally, the combined analysis of those three SNPs showed a significant locus-dosage effect between number of favorable alleles and death risk of NSCLC (Trend P = 0.002). Genetic variations in DROSHA might be associated with the survival of advanced NSCLC patients in Chinese population.

A Novel Passivity-Based Resonant Instability Suppression Method for Grid-Connected VSC

Jiancheng Zhao,Kai Li,Xiaodong Wang,Chuan Xie,Hongbing Xu 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.1

The interaction between the three-phase voltage source converters (VSCs) and the power grid may cause high-frequency resonant instable problems. Studies have indicated that the non-passivity of VSCs is the main reason that leads to the resonances. The above-mentioned passive means that the equivalent output admittance of the VSC has a positive real part. In this paper, a novel damped Smith predictor is proposed to suppress the resonant instability problem that caused by time delay. The research proved that the proposed Smith predictor can signifi cantly improve the passivity of the VSC by reducing the width of the negative real part at the high-frequencies. Simulation and experimental results demonstrate that the proposed Smith predictor can distinctly improve the robustness of the VSC.

Stress-induced expression of the sweetpotato gene <i>IbLEA14</i> in poplar confers enhanced tolerance to multiple abiotic stresses

Ke, Qingbo,Park, Sung-Chul,Ji, Chang Yoon,Kim, Ho Soo,Wang, Zhi,Wang, Shiwen,Li, Hongbing,Xu, Bingcheng,Deng, Xiping,Kwak, Sang-Soo Elsevier 2018 Environmental and experimental botany Vol.156 No.-

<P><B>Abstract</B></P> <P>Late embryogenesis abundant (LEA) proteins are small, highly hydrophilic proteins that act as protectors of macromolecules and increase abiotic stress tolerance in plants. We previously reported that overexpressing sweetpotato <I>IbLEA14</I> under the control of the <I>CaMV 35S</I> promoter increased osmotic and salt stress tolerance in transgenic sweetpotato calli. In this study, we generated transgenic poplar plants (<I>Populus alba × P. glandulosa</I>) expressing <I>IbLEA14</I> under the control of the oxidative stress-inducible <I>SWPA2</I> promoter (referred to as SL plants). Among the 15 SL plants obtained, three lines (SL2, SL7, and SL12) were established based on <I>IbLEA14</I> transcript levels, tolerance to salt stress and Southern blot analysis. The SL plants exhibited less damage in response to methyl viologen-mediated oxidative stress than non-transgenic (NT) plants. SL plants also showed enhanced tolerance to drought, salt, and heat stress, which was associated with higher photosystem II efficiency and lower malondialdehyde levels compared with NT plants. Furthermore, SL plants had higher levels of monolignol biosynthesis-related gene transcripts under drought stress compared with NT plants. Finally, SL plants exhibited increased tolerance to heat stress, which is associated with the high thermostability of IbLEA14 protein. SL plants might be useful for reforestation on global marginal lands, including desertification and reclaimed areas.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>IbLEA14</I> gene was transformed into poplar plants. </LI> <LI> Transgenic poplars exhibit increased tolerance to MV-mediated oxidative, drought, salt and heat stress. </LI> <LI> Overproduction of IbLEA14 affects lignification and thermostability of transgenic poplars. </LI> </UL> </P>