http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cytokine and Tumor Environments
Jin Tae Hong1*, Ju Kyung Song, Sun Mi Kwon, Byung Woo Ahn, Youngsoo Kim, Sang Bae Han 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
Cytokines are known to function as regulatory molecules that can be produced by virtually every nucleated cell type in the body, including lymphocytes, monocytes/macrophages, epithelial cells, fibroblasts, and many others. Cytokines include lymphocyte-derived factors (lymphokines), monocyte-derived factors (monokines), hematopoietic factors (colony-stimulating factors), connective tissue/growth factors, and chemotactic chemokines. Cytokines released in response to infection can affect tumor development in different ways. When exposed to infectious agents, cytokines are secreted by sentinel cells, such as macrophages and dendritic cells. These cytokines include interleukin 1 (IL-1) and tumor necrosis factor-α, as well as others, such as IL-6, IL-12, and IL-18. When released in sufficient quantities, these molecules can cause inflammation. Chronic inflammation is highly associated with tumor initiation, promotion, and progression. In this article, we review the roles and mechanisms of cytokines in tumor development.
Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.
Byzantine Attack Identification in Coded Computing via Group testing Approach
Hong Sang Woo(홍상우),Yang Hee cheol(양희철),Shin Won Jae(신원재),Lee Jung woo(이정우) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2
Coded computing has proved its efficiency in handling a straggler issue in distributed computing framework. It uses error correcting codes to mitigate the effect of the stragglers. However, in a coded distributed computing framework, there may exist Byzantine workers who send the wrong computation results to a master in order to contaminate the overall computation output. Therefore, it is essential to identify Byzantine workers from their computation results. In this paper, we consider the Byzantine attack identification problem in distributed computing for distributed matrix multiplication tasks. We propose a new coding scheme, namely locally testable codes, and suggest a hierarchical group testing method for Byzantine attack identification on locally testable codes. We show that the hierarchical group testing method requires a smaller number of tests than naively applying the conventional group testing method for the existing coded computing schemes.
Low Cost MEMS-IMU Based DR/GPS Integrated System in Urban Environment
Woo Jung Park,Jae Hong Lee,Chang Ho Kang,Myung Hwan Seo,Sang Yeon Park,Jong Yun Yeo,Jin Woo Song,Chan Gook Park 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
In this paper, we propose an MEMS-IMU Based 10<SUP>th</SUP> order DR/GPS integrated system. Existing low cost MEMS based INS/GPS integrated systems are not applicable to autonomous vehicle localization that needs navigation error under 3m. To improve the performance of the MEMS based navigation system, odometer based DR/GPS formulation was proposed. By substituting MEMS accelerometer to odometer, velocity and position errors of navigation solution are reduced. The proposed method is tested for a land vehicle in urban area including GPS outage section. The experimental results show that the proposed method reduced the navigation error in the GPS outage section than MEMS INS/GPS system.
General Characteristics of Korean Propolis
Woo, Soon Ok,Han, Sang Mi,Hong, Inpyo,Choi, Yong Soo,Lee, Kwang Gill,Yeo, Joo Hong,Kweon, Hae Yong,Lee, Myoung Ryeol,Lee, Man Young Korean Society of Sericultural Science 2012 International Journal of Industrial Entomology Vol.25 No.2
The propolis was collected from the whole part of Korea Peninsula, such as central, southern, and Jeju island, to analyze the general composition including total flavonoid and phenolic contents, heavy metals, colors, amino acids, and crude lipid. The total flavonoid and phenolic contents of middle region in Korea Peninsula (4.26% and 13.06 g/100 g gallic acid) were higher than southern region (2.53%, 10.9 g/100 g gallic acid) and Jeju island (0.03%, 7.22g/100 g gallic acid), respectively. The heavy metals contents showed that Zn contents were found in $0.44{\pm}0.2ppm$ and a harmful heavy metal such as Cr, Cd, Pb, Ni, Cu, As, and Hg were not detected at all in our experiment. The colors of extracted propolis showed a various spectrum from yellow to red purple. Various amino acids were also detected as proline, valine, methionine and the average crude lipid contents of propolis were 42.4%. All data collected in South Korea were very first executed in our institution for the purposes of utilizing and developing the industrial insects, honeybees as well as silkworm.
Dietary intake of nutrients and lung function in dust exposed subjects living near cement factories
( Woo Jin Kim ),( Yoonki Hong ),( Sung Ok Kwon ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background/Objective: Dietary intake appears to be important in both the development and management of respiratory diseases, however, the evidence is inconsistent. Our study examined the association between dietary nutrient intake and lung function in Korean adults. Methods: The cross-sectional analysis included 414 adults form the COPD in Dusty Areas (CODA) cohort whose lung function and dietary information was measured. The dietary intake was estimated using a 24-hour recall. We estimated adjusted differences in lung function associated with each nutrient categorized into tertiles, in mutivariable regression models after adjustment for potential confounders. Results: After controlling for potential confounders, vitamin A and vitamin E intake was significantly associated with higher forced vital capacity (FVC) in all the study subjects. Similar pattern of the association was found in men regarding vitamin E, and β-carotene. Male in the highest tertile intake of fiber had mean FEV1 and FVC measurements that were 172.3 ml and 238.6 ml higher than the lowest tertile of intake. After stratification by smoking status among male, the protective associations observed for fiber intake were present only in current smokers, but not in former/never-smokers. Conclusions: These results indicate that dietary intake of fiber exerts a beneficial effect on the lung function in male, particularly in current smoker. A diet rich in fiber-containing foods may play a role in improving lung health.
( Sang-su Kim ),( Cheol Hong Kim ),( Ji Wook Kim ),( Hsi Chiang Kung ),( Tae Woo Park ),( Yu Som Shin ),( Ju Deok Kim ),( Siejeong Ryu ),( Wang-joon Kim ),( Yung Hyun Choi ),( Kyoung Seob Song ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.10
CLB<sub>2.0</sub>, a constituent of PM, induces secretion of multiple cytokines and chemokines that regulate airway inflammation. Specifically, IL-6 upregulates CLB<sub>2.0</sub>-induced MUC5AC and MUC1 expression. Interestingly, of the tight junction proteins examined, claudin-1 expression was inhibited by CLB<sub>2.0</sub>. While the overexpression of claudin-1 decreased CLB<sub>2.0</sub>-induced MUC5AC expression, it increased the expression of the anti-inflammatory mucin, MUC1. CLB<sub>2.0</sub>-induced IL-6 secretion was mediated by ROS. The ROS scavenger N-acetylcysteine inhibited CLB<sub>2.0</sub>-induced IL-6 secretion, thereby decreasing the CLB<sub>2.0</sub>-induced MUC5AC expression, whereas CLB<sub>2.0</sub>-induced MUC1 expression increased. CLB<sub>2.0</sub> activated the ERK1/2 MAPK via a ROS-dependent pathway. ERK1/2 downregulated the claudin-1 and MUC1 expressions, whereas it dramatically increased CLB<sub>2.0</sub>-induced MUC5AC expression. These findings suggest that CLB<sub>2.0</sub>-induced ERK1/2 activation acts as a switch for regulating inflammatory conditions though a ROS-dependent pathway. Our data also suggest that secreted IL-6 regulates CLB<sub>2.0</sub>-induced MUC5AC and MUC1 expression via ROS-mediated downregulation of claudin-1 expression to maintain mucus homeostasis in the airway. [BMB Reports 2017; 50(10): 516-521]
The Sagittal Balance of Cervical Spine : Comprehensive Review of Recent Update
Sang Hoon Lee,Tae Hwan Kim,Seok Woo Kim,Hyun Take Rim,Heui Seung Lee,Ji Hee Kim,In Bok Chang,Joon Ho Song,Yong Kil Hong,Jae Keun Oh 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.6
The cervical spine plays a critical role in supporting the skull, maintaining horizontal gaze, and facilitating walking. Its unique characteristics, including the widest range of motion among spinal segments, have led to extensive research on cervical sagittal alignment. Various parameters have been proposed to evaluate cervical alignment, with studies investigating their clinical significance, correlation with symptoms, and implications for surgical interventions. Recent findings suggest that cervical sagittal alignment not only impacts the cervical spine but also influences global spine-pelvic alignment through compensatory mechanisms. This comprehensive review examines classical and new parameters of cervical sagittal alignment and considers the dynamic and muscular factors associated with it.