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후천성 말단성 섬유각화종 - 항 Factor XIIIa 항체를 이용한 면역조직화학 염색 -
서호석(Ho Seok Suh),류병직(byung Jick Ryu),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6
In normal hurnan dermis, factor XIIIa positive dermal dendrocyte are located in the papillary areas closely associated with blood vessels and the upper reticular dem These cells represent a specific type of bone marrow derived dermal cells, distinct from Langerhans cells having some features in common with rnonocyte/macrophage lineage and with potential antier presenting activity. Although the significance of these cells has not yet been fully established, it been suggested that they play a major role in skin immune iesponses, in collagen synsthesis regultic and in wound repair. We report a case of acaqired fibrokeratoma which is studiec conventional histopathology and immunohistochemistry. Histopathologic findings of this case showed ovascular proliferation and the increased presence of fibroblast like cells as a common fe;ture of these benign tumors. Immunohistochemical staining with anti factor XIIIa antibody deiaoi strates increased numbera of positive dendritic cells in the upper dermis. There finding supports the fat that some fibroblagt like cells in the upper dermis of acquireid fibrokeratoma may be factor XIIIa positive dermal dendritic cells. (Kor J Dermatol 1994; 32(6): 1131-1135)
서호석 ( Ho Seok Suh ),지민선 ( Min Sun Jee ),김형훈 ( Hyung Hun Kim ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1
Cutaneous larva migrans(CLM) is a creeping cutaneous eruption that results from skin invasion by the larval form of nematodes. We experienced two patients who had typical clinical findings of CLM. One patient had a history of contact with possibly contami
서호석,유철인,이충렬,이지호,김양호,이원신,최지호,성경제,고재경,문기찬 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.4
목적: 울산지역에 소재한 대규모 조선업종 근로자 1,419명을 대상으로 족부백선의 유병률을 조사하고 족부백선의 유병률에 미치는 요인을 조사하여 족부백선의 작업관련성을 알고자 본 연구를 실시하였다. 방법: 근로자 건강진단시 족부백선의 유뮤를 확인하고, 현재 족부백선의 위험인자로 알려져 있는 여러 요인들과 작업, 환경적인 요인들에 대하여 설문조사를 실시하고, 족부백선의 임상적인 양상을 관찰하였다. 결과: 조사결과 족부백선의 유병률은 54.8%로 높게 나타났으며, 직종과 공동목욕탕 이용 유무, 안전화 착용유무, 작업형태, 가족력 유무가 족부백선이 유병률에 영향을 미치는 위험인자로 나타났으나, 다변량 분석결과 가족력과 공동목욕탕 이용만이 통계적으로 유의한 위험인자로 나타났으며(P<0.05), 안전화 착용은 통계적으로 유의하지 않았다. 결론: 이상의 결과에서 사업장내 근로자들의 족부백선의 높은 유병률과 관련된 직접적인 요인은 사업장내의 공동 목욕탕의 이용 여부와 족부백선의 가족력임을 확인할 수 있었으며, 많은 근로자들이 원인으로 지목한 안전화의 착용은 통계적인 유의성은 없었다. 따라서 족부백선이 작업과 직접적으로 관련되었다는 근거는 적은 것으로 보인다. 하지만 일반인보다 높은 유병률을 보이는 것으로 확인된 사업장내 족부백선의 유병률을 감소시키기 위해서는 위험인자로 최종 확인된 작업장 내의 공동 목욕탕의 철저한 위생관리와 함께 가족간의 감염을 예방히기 위한 개인위생관리가 필요하면, 비록 통계적인 유의성은 없었으나 여러 근로자들이 원인으로 지목한 안전화의 개선에도 노력해야 할 것으로 생각한다. Objectives: Recently, tinea pedis has been reprted to be a type of occupational dermatoses because of its high prevalence in specific working conditions. Although there is no doubt that the environment surrounding work places, the usual habits of workers erc ate intimately related to this skin conditions, there is some controversu as to whether or not this condition is a real occupational illness and what is the exact cause of the high prevalence of this illness is. In this study, the prevalence of tinea pedis in workers from the shipbuilding industry was investigated andthe risk factors of this disease were evaluated. This study also aimed to verify whether or not tinea pedis is one of the occupational diseases. Methods: The result of interviews, questionnaires and clinical findings from 1,419 workers who visited the occupational health center for an annual routine check for their health state were analyzed. Results: Among the 1,419 workers, 778 workers (54.8%)had tinea pedis. By simple logistic regression analysis, the prevalence of tinea pedis was found to e affected by some variables, including the jov category, the types of work, the kinds of footwear, whether or not they were using communal baths in the work places, and a family history of tinea pedis. In contrast, by multiple logistic regression analysis, only utilization of the communal baths in the work places and a family history of tinea pedis turned out to be statistically significant risk facrors. Conclusions: In this study, the major factors contributing to the high prevalence of tinea pedis are the use of communal baths in the workplace and a positive family history. However, the wearing of safety shoes was not statistically significant. Therefore, tinea pedis could not be confirmed to be an occupational disease. On the basis of these results, a solution to the environmental hygiene of communal bats and the personal hugiene of individuals needs to be improved in order to prevent tinea pedis.
서호석(Ho Seok Suh),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5
Beckground : Molluscum contagiosum is a common viral infect oudisease of the skin and mucous membrane that is caused by a molluscum contagiosum virus(MCV; which belongs to the poxviridae family. One of the characteristic histopathologic findings is an epidermal hyperplasia Porter and Archard reported that this phenomenon might be explained by a virus induced epidermal growth factor (EGF) like polypeptide. There was a report that epidermal prolifeation in viral infection might be modulated by other factors than the virus itself such as local immune response. Objective : The purpose of this study was to examine the expression pattern of epidermal growth factor receptor and other immunocompetent cells by immunohistochemical stainings. Method : We performed iinmunoperoxidase staining on the 11 slaecmens of formalin-fixed, paraffin-embedded molluscum lesions and 15 specimens of snap frozen mollucum lesions with nine primary antibodies(EGFR, factor XIIIa, CDla, S-100 protein, MAC 387, HLA-IR, CD4, CDS, L26) Results : EGF receptors were strongly expressed in lesional MCV ifect,ed keratinocytes. The number of CDla and factor XIIIa positive dermal dendritic cells were sigtly increased. In inflamed lesions, CD4 and HLA-DR expressions were increased in the dermis and per lesional epidermis. Conclusion : This study shows that 1) increased EGFR expression is of MCV infected keratinocytes may be related to the pathogenesis of epidermal hyperplasia. 2) helper T lyrnphocytes may operate in inflamed molluscum lesions. (Kor J Dermatol 1994;32(5):787-794)