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- 저자 : 류병직(byung Jick Ryu) (검색결과 3 건)
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정상인에서의 Substance P와 VIP에 의한 발적과 팽진 유발 실험
류병직(byung Jick Ryu),최지호(Jee Ho Choi),성경제(Jai Kyoung Koh),고재경(Kyung Jeh Sung) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.3
Background : Despite concern about information of neuropeptide, the has been no baseline study of neuropeptide in Koreans. Objective : The purpose of the study was to investigate the skin sinsitivity of substance P and VIP in normal healthy persoas. Meihods : We prepared 1000pM, 100pM, 10pM solution of substan P 1-11, substnace P 1-7, substnace P 7-11, and VIP. We injected intradermally 50ul of the br ve solutions on 12 sites of both forearms in addition plaebo. We measured the size of the area of flare and wheal along time. We repeated the same test after antihistamine intake. Results : Flare and wheal respinses were dose dependent. Injection of substance P 1-7 did not evoke wheal responses and injection of substance P 7-11 did not wake flare responses. Flare responses of substance P 1-11, ubstance P 7-11, VIP were inhibiteb antihistamine and wheal responses of VIP were inhibitedly antihistamine. Conclusion : N-terminal of subtance P is responsible for flarers onses and C-terminal of substnace P is responsible for wieal responses. Flare responses of sisance P were mediated by histamine but wheal responses osubstance P were direct effect on postcapillary venule. Flare and wheal responses of VIF were mediated by histamine. (Kor J Dermato 1995;33(3): 497-503)
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후천성 말단성 섬유각화종 - 항 Factor XIIIa 항체를 이용한 면역조직화학 염색 -
서호석(Ho Seok Suh),류병직(byung Jick Ryu),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6
In normal hurnan dermis, factor XIIIa positive dermal dendrocyte are located in the papillary areas closely associated with blood vessels and the upper reticular dem These cells represent a specific type of bone marrow derived dermal cells, distinct from Langerhans cells having some features in common with rnonocyte/macrophage lineage and with potential antier presenting activity. Although the significance of these cells has not yet been fully established, it been suggested that they play a major role in skin immune iesponses, in collagen synsthesis regultic and in wound repair. We report a case of acaqired fibrokeratoma which is studiec conventional histopathology and immunohistochemistry. Histopathologic findings of this case showed ovascular proliferation and the increased presence of fibroblast like cells as a common fe;ture of these benign tumors. Immunohistochemical staining with anti factor XIIIa antibody deiaoi strates increased numbera of positive dendritic cells in the upper dermis. There finding supports the fat that some fibroblagt like cells in the upper dermis of acquireid fibrokeratoma may be factor XIIIa positive dermal dendritic cells. (Kor J Dermatol 1994; 32(6): 1131-1135)
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최지호(Jee Ho Choi),조광현(Kwang Hyun Cho),류병직(byung Jick Ryu),성경제(Kyoung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.5
Background : A definition of granuloma is a focal chronic inflammatory response to tissue injury evolved by a poorly soluble substwice characterized by the accumulation and proliferation of the mono-nuclear histiocytic cells. The accuracy with which rnononuclear cells may be identified in skir. is much improved by the use of both heteroantisera and monoclonal antibodies directed against selected cellular antigens, Objective : Our purpose was to examine the staining patterns of anti-lysozyme, anti-a-1-antitrypsin, anti-S-100 protein antibodies, and MAC-387 monoclonal anibody in granulomatous skin diseases. Method : We performed imminoperoxidase staining(the labelled str prvidin-biotin peroxidase complex method on the formalin-fixed, paraffin-embedded tissue specimens of granulomatous skin diseases. Results : S-100 protein positive dendritic cells were demonstrated in the granulomatous infiltrates as scattered pattern and MAC-387 positive cells were predominantly found in the center of granulomas, The staining pattern and percentage of positively stained cells of a--antitrypsin were similar to those of lysozyme. A1Pha-1-antitrypsin and lysozyme positive cells w re present in the center as well as lymphohistiocytic infiltrates of granulomas. Conclusion : These data sugget that histiocytes are composed of heter igeneous groups of cells such as the mononuclear-phagocyte system and dendritic cell system. (Kor J Dermatol 1993;31(5):702-712)
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