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심한 협착이 동반된 크론병 환자에서 인플리시맵 치료 후 발생한 소장 천공
임창섭 ( Chang Sup Lim ),문원 ( Won Moon ),박선자 ( Seun Ja Park ),박무인 ( Moo In Park ),김형훈 ( Hyung Hun Kim1 ),김종빈 ( Jong Bin Kim ),최정문 ( Jeong Moon Choi ),장희경 ( Hee Kyung Chang ),이승현 ( Seung Hyun Lee ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.3
Crohn`s disease is characterized by chronic transmural inflammation of the bowel and is associated with serious complications, such as bowel strictures, abscesses, fistula formation, and perforation. As neither medical nor surgical therapy provides a cure for Crohn`s disease, the primary goals of therapy are to induce and maintain remission and prevent complications. As a biologic agent, infliximab, a monoclonal antibody to tumor necrosis factor, is indicated for refractory luminal and fistulizing Crohn`s disease that does not respond to other medical therapies or surgery. Infliximab has proven to be very effective for inducing and maintaining remission in Crohn`s disease; however, infliximab treatment has several potential complications. Here, we report a case of free perforation following a therapeutic response after an initial dose of infliximab for Crohn`s disease. This is the first case report describing a free perforation in a Crohn`s disease patient after an initial dose of infliximab. (Korean J Gastroenterol 2013;62:169-173
김형훈 ( Hyung Hun Kim ),김유선 ( You Sun Kim ),옥경선 ( Kyung Sun Ok ),류수형 ( Soo Hyung Ryu ),이정환 ( Jung Hwan Lee ),문정섭 ( Jeong Seop Moon ),이혁상 ( Hyuck Sang Lee ),이혜경 ( Hye Kyung Lee ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.6
Chronic non-granulomatous jejunoileitis is a rare disease characterized by malabsorption, abdominal pain, and diarrhea that causes shallow ulcers in the small bowel. The etiology of chronic non-granulomatous jejunolieitis remains unknown. A 69-year-old man complained of abdominal pain and lower extremity edema. A 99m-Tc albumin scan showed increased radioactivity at the left upper quadrant, suggesting protein-losing enteropathy. A small bowel follow-through did not disclose any lesions. Wireless capsule endoscopy revealed several small bowel ulcers and strictures. A jejunoileal segmentectomy with end-to-end anastomosis was performed, and the histologic examination revealed non-granulomatous ulcers with focal villous atrophy. Ruling out all other possible diagnoses, we diagnosed our patient with chronic non-granulomatous ulcerative jejunoileitis. Postoperatively, the patient`s abdominal pain and lower extremity edema improved, and the serum albumin normalized. This is the first case of chronic non-granulomatous ulcerative jejunoileitis localized by wireless capsule endoscopy and treated successfully with segment resection. (Korean J Gastroenterol 2010;56:382-386)
전형상(Jeon, Hyung-Sang),김선희(Kim, Sun-Hee),김형훈(Kim, Hyung-Hun) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.5
This study aims to review the previous studies on leisure activities through multi-dimensional literature analysis of leisure activities of the elderly and provide base data that will widen the academic ground for the promotion and development of leisure activities of elderly people. For this, targeting a total of 724 studies on the leisure activities of the elderly that were conducted from 2000 to 2015, this study set 5 categories—objects of study, methods of study, ways of collecting study data, tools of study, and the year and field of conducting study—and conducted an analysis. First, in terms of the objects of study, studies on leisure activities of the elderly targeting 60 years or older were most common, and they were followed by studies targeting 65 year or order and the ones targeting people older that. Second, as for the method of study, more than 70% of the studies were conducted quantitatively, and the ratio of qualitative studies was about 16%. Third, as for the tools of study, questionnaires were most common, which was followed by literature research, in-depth interview, and the use of statistical data. Fourth, regarding the ways of collecting study data, descriptive study took a high portion of 88%. Lastly, as for the year of conducting study, the largest number of studies was conducted from 2007 to 2012 and it peaked in 2010. As to the field of conducting study, the order of frequency was social welfare, sports, and the welfare of the elderly.
벽면 이동 로봇을 이용한 벽면 균열 위치추정에 관한연구
김현섭 ( Hyun-seop Kim ),박재민 ( Jae-min Park ),신동호 ( Dong-ho Shin ),김형훈 ( Hyung-hoon Kim ),김상훈 ( Sang-hun Kim ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2
본 논문은 진공을 이용한 흡착방식과 바퀴형 이동방식을 사용하는 벽면이동로봇의 균열 위치 추정에 관한 연구로써, 로봇의 Yaw값에 대해 PID제어를 통해 로봇의 방향을 제어 하고 이를 바탕으로 엔코더모터의 홀센서와 IMU를 기반으로 하여 균열 위치를 추정 한다. 위치 추정 성능을 검증하기 위해 실제위치와 추정된 위치를 비교하고 결과를 제시하였다.
확장이 없는 총담관 결석의 진단에서 내시경초음파검사의 유용성
이정환 ( Jung Hwan Lee ),김유선 ( You Sun Kim ),류수형 ( Soo Hyung Ryu ),이상렬 ( Sang Ryul Lee ),이수연 ( Su Yeon Lee ),박종혁 ( Jong Hyeok Park ),문정섭 ( Jeong Seop Moon ),김형훈 ( Hyung Hun Kim ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.2
Background/Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is the most accurate modality in diagnosis of choledocholithiasis. However, it carries some complications. Endoscopic Ultrasonography (EUS) is less invasive than ERCP and used for the diagnosis of choledocholithiasis. Recent studies showed that a usefulness of EUS for the diagnosis of small choledocholithiasis without common bile duct (CBD) dilatation. For such a reason, ERCP is being replaced by EUS in the diagnosis of bile duct stones. The aim of this study was to investigate the accuracy of EUS for the diagnosis of choledocholithiasis without CBD dilatation. Methods: A total of 66 patients with suspected choledocholithiasis without CBD dilatation were enrolled. EUS were performed in all cases within 48 hours after computed tomography (CT) or ultrasonography (US). Final diagnosis was obtained by ERCP or clinical course (minimum 6 months follow-up). We analyzed the accuracy of US, CT, and EUS, respectively. Results: CT and US were performed in 51 and 15 cases, respectively. CBD stones were detected in 23 (35%) patients by ERCP. EUS showed 100% sensitivity, 95% specificity, 92% positive predictive value, and 100% negative predictive value for identifying CBD stones. CT or US showed 26%, 93%, 67%, and 70%, respectively. There were no EUS-related complications. Conclusions: EUS was more effective than CT or US and as accurate as ERCP for the diagnosis of small choledocholithiasis without CBD dilatation. Thus, EUS may help to avoid unnecessary diagnostic ERCP and its complication. (Korean J Gastroenterol 2010;56:97-102)
대장 용종에서 렙틴 발현에 따른 임상병리학적인 특성의 차이
옥경선 ( Kyung Sun Ok ),김유선 ( You Sun Kim ),김형훈 ( Hyung Hun Kim ),류수형 ( Soo Hyung Ryu ),이정환 ( Jung Hwan Lee ),문정섭 ( Jeong Seop Moon ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.1
Background/Aims: Colorectal adenoma and cancer are known to be associated with obesity. Leptin, an adipocyte-derived hormone that plays a crucial role in obesity has been suggested as a growth factor in colon cancer. However, the association between adenoma and leptin remains controversial. We evaluated the leptin expression in human colorectal adenoma and its correlation to clinicopathologic factors. Methods: Leptin expression was assessed by immunohistochemistry in 91 samples of colorectal adenoma larger than 5 mm, which were removed by endoscopic polypectomy. All patients underwent colonoscopy for cancer screening at Seoul Paik Hospital from 2007 to 2008 and we only included the patients less than 50 years of age. Leptin expression and its relationship with clinicopathologic features were analyzed. Results: Eighty samples were available for the interpretation of leptin expression and showed positive in 42 (52.5%) cases and negative in 38 (47.5%) cases. As body mass index (BMI) increased based on World Health Organization (WHO) classification the positivity of leptin expression also increased (ptrend=0.02), in leptin positive group, the correlation of leptin expression with adenoma size and histological showed positive tendency without statistical significance. Conclusions: Leptin expression of colorectal adenoma was associated with BMI. The question of whether leptin contributes to colorectal adenoma development is unresolved and will require additional studies. (Korean J Gastroenterol 2010;56:20-26)
서호석 ( Ho Seok Suh ),지민선 ( Min Sun Jee ),김형훈 ( Hyung Hun Kim ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1
Cutaneous larva migrans(CLM) is a creeping cutaneous eruption that results from skin invasion by the larval form of nematodes. We experienced two patients who had typical clinical findings of CLM. One patient had a history of contact with possibly contami
정수현 ( Su Hyeon Jeong ),박무인 ( Moo In Park ),김형훈 ( Hyung Hun Kim ),박선자 ( Seun Ja Park ),문원 ( Won Moon ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.4
Background/Aims: Early gastric cancer (EGC) has a relatively long natural course compared to advanced gastric cancer (AGC). But, few studies about the natural course of EGC are currently available in the literature. In this study we investigated the natural course of EGC in patients who did not receive any treatment. Methods: All patients diagnosed with gastric cancer on endoscopy at Kosin University Gospel Hospital between January 2001 and December 2010 were reviewed. Those among them who had EGC and did not receive any treatment were enrolled, and an analysis was performed. Results: Twenty seven patients were enrolled. Nine of the enrolled patients were women and the median age was 73 years (range, 38-95). Initial endoscopic findings revealed 11 cases of protruded type, 16 cases of flat and depressed type. Histopathologic analysis indicated that there were 14 cases of well and moderately differentiated adenocarcinoma, 6 cases of poorly differentiated adenocarcinoma and signet ring cell carcinoma. Twelve patients underwent follow-up endoscopy and three of them developed AGC within a mean of 9.6 months (range, 5-12 months). Overall median survival time was 40 months and the 5-year survival rate was 45%. Conclusions: Although there were some differences in EGC progression, patients who did not receive any treatment progressed eventually. We were unable to identify specific factors predictive of median survival time in these patients.
균열로 인한 사고를 방지하기 위한 선체 균열탐지 로봇 개발
박세연 ( Se-yeon Park ),이한별 ( Han-byeol Lee ),송연주 ( Yeon-ju Song ),최훈 ( Hun Choi ),김형훈 ( Hyung-hoon Kim ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
노후 선박의 증가로 선체 검사의 필요성이 높아지고 있다. 하지만 선체 벽면의 균열을 찾고 보수하는 작업은 위험성이 높고 효율성이 낮다. 이에 본 논문에서는 선체의 벽면에 진공 흡착하여 장애물에 부딪히지 않고 선체 벽면을 이동하면서 균열을 탐지하는 로봇을 개발하였다. 선체 균열탐지 로봇은 선체 뿐만 아니라 사람이 직접 균열을 찾기 힘들거나 위험한 곳에 유용할 것이며 균열로 인한 선박 사고 발생을 줄여줄 것으로 기대된다.
소화기 ; 진행성 위암 환자에서 1차 요법으로 FOLFOX-4 병합화학 약물치료의 효과와 안정성
이천우 ( Cheon Woo Lee ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ),문원 ( Won Moon ),김형훈 ( Hyung Hun Kim ),이혜원 ( Hae Won Lee ),구기환 ( Ki Hwan Ku ),김부경 ( Bu Kyung Kim ) 대한내과학회 2012 대한내과학회지 Vol.82 No.1
This study examined the efficacy and safety of oxaliplatin-5-fluorouracil-Leucovorin (FOLFOX-4) combination chemotherapy as first-Line treatment in patients with advanced gastric cancer. This retrospective study enrolled 35 patients diagnosed with pathologically proven surgically unresectable gastric cancer who received FOLFOX-4 combination chemotherapy between August 2006 and February 2009, using medical records. The administered dose of oxaliplatin was 85 mg/㎡ for 2 hrs and Leucovorin 200 mg/㎡ for 2 hrs on day 1, 5-fluorouracil 400 mg/㎡ as a bolus and 5-fluorouracil 600 mg/㎡ for 22 hrs on days 1 and 2, every 2 weeks. The response was assessed every three cycles. Toxicity was evaluated for every course of chemotherapy according to the NCI toxicity criteria ver. 2.0. The median patient age was 61 (range 27-77) years. The median overall survival was 8.50 (6.23-10.90) months and the median time to progression was 4.50 (0.38-9.75) months. With FOLFOX-4, there was no complete remission and 19 partial responses, for a response rate of 54.3%. Over 298 cycles, anemia worse than NCI toxicity grade 3 occurred in 1.3%, Leukopenia in 1.6%, neutropenia in 9%, and thrombocytopenia in 3.2%. Grade 1-2 neuropathy occurred in 14.7% of the cycles. Neutropenic fever occurred in two cycles and the regimen was changed because of side effects in one FOLFOX-4 has a very high response rate with mild toxicity in patients with advanced gastric cancer as a first-Line treatment. (Korean J Med 2012;82:37-44)