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Dietary Phosphatidylcholine Improves Maze-Learning Performance in Adult Mice
임선영,Hiramitsu Suzuki 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
The effect of phosphatidylcholine (PC) on maze-learning performance was investigated in adult mice. Three-month-old mice were given a semipurified diet of 1%, 2.5%, or 5% PC over a period of 4 months, with their maze-learningability assessed beginning at 3 months after the start of the experiment and again 4 and 8 days later. This entailed the mea-surement of the time required by the mice to reach the maze exit and counting the number of times that mice strayed intoblind alleys in the maze. During trial 1, mice in the 5% PC diet group required significantly less time to reach the maze exitcompared with the control group (P. .05), while mice in the 1% and 2.5% PC dietary groups tended to require a shortertime to find the exit, but the differences were not significant. The number of times that mice strayed into blind alleys in themaze was significantly fewer in the 2.5% and 5% PC diet groups than in the control group during trial 1 (P. .05). The PCdiets increased the percentages of docosahexaenoic and arachidonic acids in serum but had a lesser effect on brain fatty acidcomposition. These results suggest that the intake of 5% PC diet improves learning ability in adult mice and that the improvedbrain function may be related to the provision of choline.
Ohishi, Kentaro,Hiramitsu, Tadahisa,Matsugo, Seiichi Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
We studied iron release from ferritin by irradiating the visible light, and then followed ferritin-mediated lipid peroxidation in the rod outer segment (ROS) fraction of the porcine retina. In the presence of several phosphorus compounds such as ADP and ATP, iron release from ferritin at pH 7.0 could be induced by irradiation of the visible light to the reaction mixtures. Furthermore, iron release from ferritin in the presence of ADP depended on the incubation time and the visible light irradiation. Moreover, we investigated lipid peroxidation level in the ROS fraction by two independent assay systems including the thiobarbituric acid (TBA) and ferrous oxidation/xylenol orange (FOX) methods. The visible light induced ferritin-mediated lipid peroxidation in the ROS fraction in time- and irradiance-dependent manners. In the dark condition, iron release and lipid peroxidation were not observed. Iron release from ferritin by irradiating the visible light may play an important role in the etiology of phototoxic injuries in vivo.