http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Genomic Profiling Shows Increased Glucose Metabolism in Luminal B Breast Cancer
Shigeto Ueda,Hideki Takeuchi,Takashi Shigekawa,Kazuo Matsuura,Noriko Nakamiya,Hiroshi Sano,Hiroko Shimada,Eiko Hirokawa,Akihiko Osaki,Toshiaki Saeki 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3
We had previously reported a close association between pathological response and the maximum tumor standardized uptake value (SUVmax) measured by 18F-fluorodeoxyglucose positron emission tomography prior to chemotherapy in estrogen receptor (ER)-positive breast cancer. We hypothesized that glucose hypermetabolism by luminal B tumors may result in chemotherapy responsiveness. Using a single-gene expression assay, TargetPrint® (Agendia) and a 70-gene expression classifier,MammaPrint® (Agendia), we divided 20 patients with ERpositive primary breast cancer into luminal A and luminal B subtypes and compared the tumor SUVmax value between the two groups. A significantly higher SUVmax was measured for luminal B tumors (n=10; mean±SD, 7.6±5.6) than for luminal A tumors (n=10; mean±SD, 2.6±1.2; p=0.01). Glucose hypermetabolism could help predict intrinsic subtyping and chemotherapy responsiveness as a supplement to ER, progesterone receptor, HER2,and Ki-67 histochemical scores.
Junya Yamamoto,Tatsuya Mori,Mami Hiramatsu,Yoko AKIYAMA,Hidehiko Okada,Noriyuki Hirota,Hideki Matsuura,Seitoku Namba,Tomokazu Sekine,Fumihito Mishima,Sigehiro Nishijima 한국초전도.저온공학회 2018 한국초전도저온공학회논문지 Vol.20 No.2
Removal of iron oxide scale from feed-water in thermal power plant can improve power generation efficiency. We have proposed a novel scale removal system utilizing High Gradient Magnetic Separation (HGMS). This system can be applied to high temperature and pressure area. We have conducted the lab-scale model experiments using φ50 mm filters and it demonstrated high removal efficiency in HGMS, but scale-up of the system is required toward practical use. In this study, we conducted a large scale mock-up HGMS experiment. We used the superconducting solenoidal magnet with φ400 mm bore and demonstrated that our HGMS system can achieve sufficient scale removal capacity that is required to introduce into both off-line and on-line system.
Yamamoto, Junya,Mori, Tatsuya,Hiramatsu, Mami,Akiyama, Yoko,Okada, Hidehiko,Hirota, Noriyuki,Matsuura, Hideki,Namba, Seitoku,Sekine, Tomokazu,Mishima, Fumihito,Nishijim, Sigehiro The Korea Institute of Applied Superconductivity a 2018 한국초전도저온공학회논문지 Vol.20 No.2
Removal of iron oxide scale from feed-water in thermal power plant can improve power generation efficiency. We have proposed a novel scale removal system utilizing High Gradient Magnetic Separation (HGMS). This system can be applied to high temperature and pressure area. We have conducted the lab-scale model experiments using ${\varphi}50mm$ filters and it demonstrated high removal efficiency in HGMS, but scale-up of the system is required toward practical use. In this study, we conducted a large scale mock-up HGMS experiment. We used the superconducting solenoidal magnet with ${\varphi}400mm$ bore and demonstrated that our HGMS system can achieve sufficient scale removal capacity that is required to introduce into both off-line and on-line system.
Kazuhiro Takehara,Takashi Matsumoto,Junzo Hamanishi,Kosei Hasegawa,Motoki Matsuura,Kiyonori Miura,Shoji Nagao,Hidekatsu Nakai,Naotake Tanaka,Hideki Tokunaga,Kimio Ushijima,Hidemichi Watari,Yoshihito Y 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2
Objective: The primary objective of this study was to evaluate the safety of niraparib 300 mg/dayin Japanese patients with platinum-sensitive, relapsed ovarian cancer in a maintenance setting. Methods: Phase 2, multicenter, open-label, single-arm study enrolled Japanese patients withplatinum-sensitive, relapsed ovarian cancer who had received ≥2 platinum-based regimens. The primary endpoint (incidence of grade 3 or 4 thrombocytopenia-related events within 30days after initial niraparib administration) was justified by the incidences of a global pivotalphase 3 study and its post-hoc safety analysis on thrombocytopenia, the major hematologicaladverse event of niraparib. The overall safety analysis examined other treatment-emergentadverse events (TEAEs). Results: Enrolled patients (n=19) had a median (min, max) body weight of 53.9 (40.8–79.1)kg; all but one patient weighed <77 kg. Most (94.7%) patients initially received niraparib300 mg/day but this decreased in subsequent cycles (mean±standard deviation doseintensity, 191.6±65.7 mg/day). In total, 6/19 (31.6%) patients experienced grade 3 or 4 thrombocytopenia-related events within 30 days of initial niraparib administration. Other common TEAEs included nausea, and decreased platelet or neutrophil counts. Noprogression-free or overall survival events occurred; only 1 of 4 response-evaluable patientshad a post-baseline tumor assessment (stable disease). Conclusion: The incidence of grade 3 or 4 thrombocytopenia-related events in Japaneseovarian cancer patients was similar to that in the corresponding non-Japanese study. Overall,the safety profile was acceptable and consistent with the known safety profile and previousexperience with niraparib. Trial Registration: ClinicalTrials.gov Identifier: NCT03759587
Yoko Akiyama,Suqin Li,Koshiro Akiyama,Tatsuya Mori,Hidehiko Okada,Noriyuki Hirota,Tsuyoshi Yamaji,Hideki Matsuura,Seitoku Namba,Tomokazu Sekine,Fumihito Mishima,Shigehiro Nishijima 한국초전도저온공학회 2021 초전도와 저온공학 Vol.23 No.3
The reduction of carbon dioxide emissions becomes a global issue, the main source of carbon dioxide emissions in the Asian region is the energy conversion sector, especially coal-fired power plants. We are working to develop technologies that will at least limit the increase in carbon dioxide emissions from the thermal power plants as one way to reduce carbon dioxide emissions. Our research aims to reduce carbon dioxide emissions by removing iron oxide scale from the feedwater system of thermal power plants using a superconducting high-gradient magnetic separation (HGMS) system, thereby reducing the loss of power generation efficiency. In this paper, the background of thermal power plants in Asia is outlined, followed by a case study of the introduction of a chemical cleaning line at an actual thermal power plant in Japan, and the possibility of introducing it into the thermal power plants in China based on the results.
Shibatani, Saori,Nakanishi, Motohiro,Mizuno, Nobumi,Mishima, Fumihito,Akiyama, Yoko,Okada, Hidehiko,Hirota, Noriyuki,Matsuura, Hideki,Maeda, Tatsumi,Shigemoto, Naoya,Nishijima, Shigehiro The Korea Institute of Applied Superconductivity a 2016 한국초전도저온공학회논문지 Vol.18 No.1
A Superconducting High Gradient Magnetic Separation (HGMS) system is proposed for treatment of feed-water in thermal power plant [1]. This is a method to remove the iron scale from feed-water utilizing magnetic force. One of the issues for practical use of HGMS system is to extend continuous operation period. In this study, we designed the magnetic filters by particle trajectory simulation and HGMS experiments in order to solve this problem. As a result, the quantity of magnetite captured by each filter was equalized and filter blockage was prevented. A design method of the magnetic filter was proposed which is suitable for the long-term continuous scale removal in the feed-water system of the thermal power plant.