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인슐린 비의존형 당뇨병 환자에서 혈장 Endothelin-1농도의 변화
신양수,조희충,김원식,국기용,김용화,정종훈,문철웅,배학연,양성훈 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2
Endothelin(ET) is a 21-residue peptide originally isolated from the cultured porcine endothelial cells. There are at least three genes for endothelin:endothelin-1(ET-1), endothelin-2(ET-2), and endothelin-3(ET-3). Endothelins are present in various human biological fluids including plasma, urine, breast milk, and saliva and have been found elevated plasma ET concentrations in patients with diabetes mellitus, Patients undergoing maintenance hemodialysis due to chronic renal failure, patients with acute myocardial infarction, and patients with subarachnoid hemorrhage. Endothelial cell damage is suspected to occur in diabetic patients and may be one important cause of angiopathy, a major complication in diabetes mellitus. The elevation of ET in diabetic patients may be a marker of, and further exacerbate, their vascular disease. We measured the levels of ET-1 in plasma of 50 patients with non-insulin dependent diabetes mellitus(NIDDM) and 25 normal subjects by radioimmunoassay. The plasma ET-1 concentration (mean±S.D.) in NIDDM was 6.461 A2.510 f㏖/ ㎖, and was significantly higher than in normal subjects (4.567±1.155f㏖/㎖) (P<0.05). The plasma ET-1 concentration (mean±S.D.) in diabetic retinopathy group( 7.15±2.454 f㏖/ml) was significantly elevated than those in otherwise uncomplicated groups (5.348±2.390 f㏖/㎖)(P<0.01). The correlation between any clinical parameters and plasma ET-1 levels in NIDDM was not significant, In conclusion, this study suggest that the elevated levels of ET-1 in diabetic patients may be play a important role in the pathogenesis of diabetic complications.
김문선,이귀영,최은영,김동희,장병수 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.3
본 연구는 색상을 함유하고 있지 않은 자연계열의 염모제인 9/00과 14/00을 여성의 건강모발에 염색한 후 염색된 모발을 열분석과 주사전자현미경을 이용하여 모발의 물리·화학적인 변화를 규명하였다. 열분석에서 정상 모발시료의 경우 열에 대한 연소 반응이 비교적 빠르게 나타났으며, 9/00 염색모발의 경우에는 건강모발과 14/00 염색 모발의 중간 정도의 연소반응을 나타냈고, 14/00 염색 모발의 경우에는 열에 대한 연소반응이 비교적 느리게 나타나는 것을 확인하였다. 이는 고명도의 염모제일수록 모발의 수분 함유량이 감소되었다는 것을 의미하며, 모발 내부로 침투한 산화물과 염료 분자로 인하여 모발의 화학적 변화가 야기된 것으로 사료된다. Morphological and physicochemical changes of a woman’s virgin hair treated with various dye depths were investigated by using scanning electron microscopy and thermal analyzer. With the hair treated with the dye of the high brightness level, the speed of weight decrease was slower than compared with thermal analysis weight of a normal hair sample. We confirmed that the moisture content and protein composition of hair were changed depending on level depth of coloring agent. Moreover oxidative residues and dye molecules penetrated into the hair cause chemical changes of hair structure. As a result, the heat reaction speed of hair treated with high level coloring agent was made slower than normal hair.