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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Helium Recondensing System Utilizing Cascade Roebuck Refrigerators
Sang Kwon Jeong,Chang Gyu Lee,Je Heon Jung 대한설비공학회 2000 International Journal Of Air-Conditioning and Refr Vol.8 No.2
This paper describes a design of the helium-recondensing system utilizing cascade Roebuck refrigerators. Superconducting generator or motor has the superconducting field winding in its rotor that should be continuously cooled by cryogen. Since liquid helium transfer from the stationary system to the rotor is problematic, cumbersome, and inefficient, the novel concept of a rotating helium-recondensing system is contrived. The vaporized cold helium inside the rotor is isothermally compressed by centrifugal force and expanded sequentially in cascade refrigerators until the helium is recondensed at 4.2 K. There is no helium coupling between the rotor and the stationary liquid helium storage. Thermodynamic analysis of the cascade refrigeration system is performed to determine the key design parameters. The loss mechanisms are explained to identify entropy generation that degrades the performance of the system.
Electron beam scattering device for FLASH preclinical studies with 6-MeV LINAC
Jeong, Dong Hyeok,Lee, Manwoo,Lim, Heuijin,Kang, Sang Koo,Lee, Sang Jin,Kim, Hee Chang,Lee, Kyohyun,Kim, Seung Heon,Lee, Dong Eun,Jang, Kyoung Won Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.4
In this study, an electron-scattering device was fabricated to practically use the ultra-high dose rate electron beams for the FLASH preclinical research in Dongnam Institute of Radiological and Medical Sciences. The Dongnam Institute of Radiological and Medical Sciences has been involved in the investigation of linear accelerators for preclinical research and has recently implemented FLASH electron beams. To determine the geometry of the scattering device for the FLASH preclinical research with a 6-MeV linear accelerator, the Monte Carlo N-particle transport code was exploited. By employing the fabricated scattering device, the off-axis and depth dose distributions were measured with radiochromic films. The generated mean energy of electron beams via the scattering device was 4.3 MeV, and the symmetry and flatness of the off-axis dose distribution were 0.11% and 2.33%, respectively. Finally, the doses per pulse were obtained as a function of the source to surface distance (SSD); the measured dose per pulse varied from 4.0 to 0.2 Gy/pulse at an SSD range of 20-90 cm. At an SSD of 30 cm with a 100-Hz repetition rate, the dose rate was 180 Gy/s, which is sufficient for the preclinical FLASH studies.