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Heeji Jo,이현준,장성주,모상현,정재훈,박철승 한국생약학회 2021 Natural Product Sciences Vol.27 No.3
Sophora flavescens Ait. (Fabaceae) is a medicinal plant widely founded in Northeast Asia, and its dried root (Kushen) has been used as a traditional Chinese herbal medicine. The therapeutic effects of Kushen in micturition disorder was not investigated comprehensively yet. In the present study, we examined and compared the efficacy of three batches of Kushen extract using different ethanol content through an in vitro cell-based assay. Among them, we chose the batch with the highest efficacy and augmented the volume of extract for industrial purpose. The bulk extract was examined in its efficacy in the in vitro cell-based assay, and the therapeutic effects through an in vivo behavioral assay of OAB rats. The main components of the extracts were analyzed by liquid chromatography. Cytotoxicity of the extracts was investigated by MTT assay. The overall efficacy of the extract was as much as, or more than, kurarinone, a potent BKCa channel activator. Thus, the extract was a potent relaxant of urinary smooth muscle by upregulating the activity of BKCa channel. The Kushen extract could be explored as an alternative medicine against overactive bladder patients indicating severe dysfunction of BKCa channel.
간호학생의 웰 다잉에 대한 인식과 사전연명의료의향서에 대한 지식
전경자(June Kyung Ja),정소현(Jeong Sohyeon),안희지(Ah Heeji),홍예경(Hong Yekyung),이윤진(Lee Yoonjin),김윤아(Kim Yoonah),조수연(Jo Sooyeon) 한국농촌간호학회 2019 한국농촌간호학회지 Vol.14 No.1
Purpose: The purpose of this study was to describe nursing students’ perception of well-dying and knowledge for Advanced Directives. Methods: Nursing students from one university were selected for the research and a survey was carried out during March and April, 2019. A total of 133 nursing students participated in this study. Data were analyzed using t-test, ANOVA, x2 test with SPSS statistics 21.0. Results: According to the results, the mean score for perception of well dying was 3.00±0.31, and knowledge for Advance Directives was 9.05±2.20. Perception of well-dying was significantly different by grade group. Knowledge for Advance Directives was significantly different by pre-education experience. Conclusion: In order to improve the nursing students knowledge for advanced directives, it is necessary to develop education program and provide them through the total school years.