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Harun, Zaliha,Ghazali, Ahmad Rohi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Detoxifying enzymes are present in most epithelial cells of the human gastrointestinal tract where they protect against xenobiotics which may cause cancer. Induction of examples such as glutathione S-transferase (GST) and its thiol conjugate, glutathione (GSH) as well as NAD(P)H: quinoneoxidoreductase (NQO1) facilitate the excretion of carcinogens and thus preventing colon carcinogenesis. Pterostilbene, an analogue of resveratrol, has demonstrated numerous pharmacological activities linked with chemoprevention. This study was conducted to investigate the potential of pterostilbene as a chemopreventive agent using the HT-29 colon cancer cell line to study the modulation of GST and NQO1 activities as well as the GSH level. Initially, our group, established the optimum dose of 24 hours pterostilbene treatment using MTT assays. Then, effects of pterostilbene ($0-50{\mu}M$) on GST and NQO1 activity and GSH levels were determined using GST, NQO1 and Ellman assays, respectively. MTT assay of pterostilbene ($0-100{\mu}M$) showed no cytotoxicity toward the HT-29 cell line. Treatment increased GST activity in the cell line significantly (p<0.05) at 12.5 and $25.0{\mu}M$. In addition, treatment at $50{\mu}M$ increased the GSH level significantly (p<0.05). Pterostilbene also enhanced NQO1 activity significantly (p<0.05) at $12.5{\mu}M$ and $50{\mu}M$. Hence, pterostilbene is a potential chemopreventive agent capable of modulation of detoxifiying enzyme levels in HT-29 cells.
Prediction of compressive strength of lightweight mortar exposed to sulfate attack
Harun Tanyildizi 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.2
This paper summarizes the results of experimental research, and artificial intelligence methods focused on determination of compressive strength of lightweight cement mortar with silica fume and fly ash after sulfate attack. The artificial neural network and the support vector machine were selected as artificial intelligence methods. Lightweight cement mortar mixtures containing silica fume and fly ash were prepared in this study. After specimens were cured in 20±2°C waters for 28 days, the specimens were cured in different sulfate concentrations (0%, 1% Mg〖SO〗_4^(-2), 2% Mg〖SO〗_4^(-2), and 4% Mg〖SO〗_4^(-2) for 28, 60, 90, 120, 150, 180, 210 and 365 days. At the end of these curing periods, the compressive strengths of lightweight cement mortars were tested. The input variables for the artificial neural network and the support vector machine were selected as the amount of cement, the amount of fly ash, the amount of silica fumes, the amount of aggregates, the sulfate percentage, and the curing time. The compressive strength of the lightweight cement mortar was the output variable. The model results were compared with the experimental results. The best prediction results were obtained from the artificial neural network model with the Powell-Beale conjugate gradient backpropagation training algorithm.
The Effect of Phoenix dactylifera on Salivary Mutans Streptococci
Harun. A. Gunawan, Ariadna Djais, Soeherwin Mangundjaja 대한임상예방치과학회 2010 International Journal of Clinical Preventive Denti Vol.6 No.1
Background: Phoenix dactylifera of date palm is known as a healthy food since a long time ago, because it has a high tannin content and are used medicinally proposed. One of the benefits is the capability to inhibit the growth of oral bacteria. Objectives: A clinical trial was carried out to investigate the effect of Phoenix dactylifera of date palm on mutans streptococci inhibiting the growth of the salivary mutans streptococci for a period one week consumption. Methods: Before enrolled in the study, respondents fill and signature the informed consent. Twenty respondents participated as the subjects on the clinical trial, conducting two times of treatment as follows: twenty as treatment groups before and after consuming date palm of Phoenix dactylifera and the twenty subjects as control groups before and after consuming non-date palm of Phoenix dactylifera. Saliva samples were collected before and after consuming date palm of Phoenix dactylifera and with a non-date palm of Phoenix dactylifera. A serial dilution was made, followed by inoculating on TYS20B medium (Schaeken, M.J.M, van der Hoeven, J.S and Franken, H.C.M, 1986). Data which were obtained from colony forming units of salivary mutans streptococci grew on the TYS20B medium before and after consuming date palm of Phoenix dactylifera were analyzed in a descriptive and “t”test. Results: Results showed that there is no significance in the average amount of Streptococcus mutans colonies between before and after consuming non-date palm of Phoenix dactylifera. However, a significant difference was found respectively as results before and after consuming date palm of Phoenix dactylifera. Conclusion: We concluded that date palm of Phoenix dactylifera has anti microbial activity against local strains of Streptococcus mutans isolated from human harbouring species. Therefore in a long term of consuming date palm of Phoenix dactylifera caries can be prevented.
Harun-Or-Rashid, Mohammad,Song, Jun-Beom,Byun, Young-Seop,Kang, Beom-Soo The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4
When the speed of a coaxial rotor helicopter in forward flight increases, the wake skew angle of the rotor increases and consequently the position of the vena contracta of the upper rotor with respect to the lower rotor changes. Considering ambient air and the effect of the upper rotor, this study proposes a nonuniform inflow model for the lower rotor of a coaxial rotor helicopter in forward flight. The total required power of the coaxial rotor system was compared against Dingeldein's experimental data, and the results of the proposed model were well matched. A plant model was also developed from first principles for flight simulation, unknown parameter estimation and control analysis. The coaxial rotor helicopter used for this study was manufactured for surveillance and reconnaissance and does not have any stabilizer bar. Therefore, a feedback controller was included during flight test and parameter estimation to overcome unstable situations. Predicted responses of parameter estimation and validation show good agreement with experimental data. Therefore, the methodology described in this paper can be used to develop numerical plant model, study non-uniform inflow model, conduct performance analysis and parameter estimation of coaxial rotor as well as other rotorcrafts in forward flight.
Harun Akkus,Hayrettin Duzcukoglu,Omer Sinan Sahin 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.1
This study utilized experimental and finite element methods to investigate the mechanical behavior of aluminum honeycomb structures under compression. Aluminum honeycomb composite structures were subjected to pressing experiments according to the standard ASTM C365. Resistive forces in response to compression and maximum compressive force values were measured. Structural damage was observed. In the honeycomb structure, the cell width decreased as the compressive force increased. Results obtained with finite element models generated using ANSYS Workbench 15 were validated. Experimental results paralleled the finite element modeling results. The ANSYS results were approximately 85 % reliable.