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Dohyung Kee,Bo Gyung Jeong,Jae Chun Lee,Kyung Min Hwang,Han Byel Lee 대한인간공학회 2014 大韓人間工學會誌 Vol.33 No.2
Objective: This study aims to develop a new desk with a built-in bookholder and desktop-mounted sliding drawer for reducing stress of seated reading postures and to analyze its effect. Background: It is general for readers to bend their back and neck when reading books on desks, which may result in high back and neck postural stress. In addition, postures using vertically layered drawers positioned at the side of users may be awkward. Method: For reducing the postural stress, a new desk with a built-in bookholder and sliding drawer was developed based on a standard of KS G 4208 for student desk. The muscle activities of reading postures on both existing and new desks were measured using EMG, in which seven male and three female college students participated. The postural stress, and musculoskeletal discomfort and ease of usage for existing and new drawers were analyzed by RULA and questionnaire survey, respectively. Results: Compared to existing desk, the muscle activity for the new desk with a bookholder was reduced by 47% when reading books. In addition, musculoskeletal discomforts in the shoulder, neck and low back were significantly lower when using the new desk with a bookholder. Although the stresses for postures using the desktopmounted sliding drawer and general drawer were not significantly different, the questionnaire survey revealed that the new desktop-mounted sliding drawer is easier to use. Conclusion: A new desk developed in this study significantly reduced postural stress and enhanced subjective preference when reading. Application: This would be useful when developing new desks with low postural stress.
Yin Guo Nan,Kim Do-Kyun,Kang Ji In,Im Yebin,Lee Dong Sun,Han Ah-reum,옥지연,Choi Min-Ji,Kwon Mi-Hye,Limanjaya Anita,Jung Saet-Byel,Yang Jimin,Min Kwang Wook,Yun Jeongwon,Koh Yongjun,Park Jong-Eun,Hwang D 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications. One prevalent complication is diabetic erectile dysfunction (ED), which is more severe and more resistant to treatment than nondiabetic ED. The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1) is a modulator of TGF-β-mediated angiogenesis and has been proposed as a biomarker for a variety of diseases, including DM. Here, we found that the adhesion GPCR latrophilin-2 (LPHN2) is a TGF-β-independent receptor of LRG1. By interacting with LPHN2, LRG1 promotes both angiogenic and neurotrophic processes in mouse tissue explants under hyperglycemic conditions. Preclinical studies in a diabetic ED mouse model showed that LRG1 administration into the penile tissue, which exhibits significantly increased LPHN2 expression, fully restores erectile function by rescuing vascular and neurological abnormalities. Further investigations revealed that PI3K, AKT, and NF-κB p65 constitute the key intracellular signaling pathway of the LRG1/LPHN2 axis, providing important mechanistic insights into LRG1-mediated angiogenesis and nerve regeneration in DM. Our findings suggest that LRG1 can be a potential new therapeutic option for treating aberrant peripheral blood vessels and neuropathy associated with diabetic complications, such as diabetic ED.