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      • SCOPUSKCI등재

        Covalent Immobilization of Trypsin on a Novel Aldehyde-Terminated PAMAM Dendrimer

        Hamidi, Aliasghar,Rashidi, Mohammad R.,Asgari, Davoud,Aghanejad, Ayuob,Davaran, Soodabeh Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.7

        Dendrimers are a novel class of nonlinear polymers and due to their extensive applications in different fields, called versatile polymers. Polyamidoamine (PAMAM) dendrimers are one of the most important dendrimers that have many applications in nanobiotechnology and industry. Generally aldehyde terminated dendrimers are prepared by activation of amine terminated dendrimers by glutaraldehyde which has two problems, toxicity and possibility of crosslink formation. In this study, novel aldehyde-terminated PAMAM dendrimer was prepared and used for covalent immobilization of trypsin by the aim of finding a special reagent which can prevent crosslinking and deactivation of the enzyme. For this purpose aminoacetaldehydedimethylacetal (AADA) was used as spacer group between aldehyde-terminated PAMAM and trypsin.The findings of this study showed that immobilization of trypsin not only resulted higher optimal temperature, but also increased the thermal stability of the immobilized enzyme in comparison to the free enzyme.

      • SCIESCOPUS

        Effect of clay mineral types on the strength and microstructure properties of soft clay soils stabilized by epoxy resin

        Hamidi, Salaheddin,Marandi, Seyed Morteza Techno-Press 2018 Geomechanics & engineering Vol.15 No.2

        Soft clay soils due to their various geotechnical problems, stabilized with different additives. Traditional additives such as cement and lime will not able to increase the soil strength properties significantly. So, it seems necessary to use new additives for increasing strength parameters of soft clay soils significantly. Among the new additives, epoxy resins have excellent physical and mechanical properties, low shrinkage, excellent resistance to chemicals and corrosive materials, etc. So, in this research, epoxy resin used for stabilization of soft clay soils. For comprehensive study, three clay soil samples with different PI and various clay mineral types were studied. A series of uniaxial tests, SEM and XRD analysis conducted on the samples. The results show that using epoxy resin increases the strength parameters such as UCS, elastic modulus and material toughness about 100 to 500 times which the increase was dependent on the type of clay minerals type in the soil. Also, In addition to water conservation, the best efficiency in the weakest and most sensitive soils is the prominent results of stabilization by epoxy resin which can be used in different climatic zones, especially in hot and dry and equatorial climate which will be faced with water scarcity.

      • KCI등재

        DERIVATIONS OF MV-ALGEBRAS FROM HYPER MV-ALGEBRAS

        Hamidi, M.,Borzooei, R.A. The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.3

        In this paper, we investigate some new results in MV-algebras and (strong) hyper MV-algebras. We show that for any infinite countable set M, we can construct an MV-algebra and a strong hyper MV-algebra on M. Specially, for any infinite totally bounded set, we can construct a strong hyper MV-algebra on it. Then by considering the concept of fundamental relation on hyper MV-algebras, we define the notion of fundamental MV-algebra and prove that any MV-algebra is a fundamental MV-algebra. In practical, we show that any infinite countable MV-algebra is a fundamental MV-algebra of itself, but it is not correct for finite MV-algebras.

      • KCI등재

        Host-ectoparasite associations; the role of host traits, season and habitat on parasitism interactions of the rodents of northeastern Iran

        Hamidi Kordiyeh,Bueno-Marí Rubén 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1

        Rodents play a significant role as reservoirs of zoonotic diseases. Nevertheless, in general their ectoparasite assemblage and host-ectoparasite associations are poorly known. This study intended to provide new insights into the relationships between ectoparasites and rodents in northeastern Iran. Rodents were captured using live traps during the years 2016–2020, and their ectoparasites were collected. Parasitological indices such as infestation rate, prevalence and mean intensity of infestation were analyzed. A total of 284 rodents, belonging to 17 species, were trapped and found to be infested by 178 ectoparasites from five orders Siphonaptera, Phthiraptera, Ixodida, Mesostigmata and Trombidiformes. The overall infestation rate was 50.3%. The flea Nosopsyllus fasciatus and the louse Polyplax asiatica dominated among all fleas and lice, respectively. Haemaphysalis punctata and Haemolaelaps sp. were recorded as the most abundant tick and mite, respectively. Nosopsyllus fasciatus exhibited low and Polyplax asiatica moderate host specificity. Approximately 64.2% of ectoparasites shared more than one host, and others were singletons. Seasonal fluctuations were found in the occurrence of ectoparasite; fleas and lice were more abundant in spring and winter, respectively. Ticks demonstrated high abundance in spring and summer and mites were more common in autumn. The overall prevalence of ectoparasite on male rodents was greater than that on females (56.4% vs. 44.4%), while similar mean intensities were detected for both sexes. This study extends the knowledge on the distribution, seasonality and host choice of four main groups of ectoparasites in association with rodents. Further studies are needed to provide deep insight into how relationships and interactions between ectoparasite and rodents are formed, and how they can be applied in epidemiology.

      • SCOPUSSCIEKCI등재

        Incidence of Venous Thromboembolic Complications in Instrumental Spinal Surgeries with Preoperative Chemoprophylaxis

        Hamidi, Saeed,Riazi, Mahdieh The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.2

        Objective : Venous thromboembolism (VTE) after spinal surgery affects a patients' postoperative recovery and also carries a mortality risk. Some studies recommended chemical prophylaxis for high-risk patients and for those after complex spinal surgeries. However, chemoprophylaxis for VTE in spinal surgery is underemployed and there is no agreement on the use of VTE prophylaxis in spinal surgery. The aim of this study was to document the incidence of VTE after an elective instrumental spinal surgery, among those receiving preoperative chemoprophylaxis as compared with patients who did not receive it. Methods : This study was carried out on eighty-nine patients allocated randomly to receive either low molecular weight heparin (LMWH) or no prophylaxis before elective instrumental spinal surgery. All patients received postoperative compression stockings. A compression Doppler ultrasonography was performed for all patients to detect postoperative deep vein thrombosis. In addition, further imaging studies were performed for patients suspected of VTE. Results : Three (3.3%) patients were diagnosed with VTE. One of them had received preoperative chemoprophylaxis. There were no significant difference in incidence of VTE between the two groups (p>0.95; 95% confidence interval, 0.06-8.7). Laterality of gender and postsurgical recumbence duration were all independent predictors of VTE (p=0.01 and p<0.001, respectively). Conclusion : The difference in the incidence of thromboembolic complications between the two groups was not significant. Moreover, we found that preoperative prophylactic LMWH injection has no major bleeding complications altering postoperative course; still, the issue concerning the initiation time of chemoprophylaxis in spinal surgery remains unclear.

      • Polycyclic Aromatic Hydrocarbons (PAHs) and their Bioaccessibility in Meat: a Tool for Assessing Human Cancer Risk

        Hamidi, Elliyana Nadia,Hajeb, Parvaneh,Selamat, Jinap,Razis, Ahmad Faizal Abdull Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1

        Polycyclic aromatic hydrocarbons (PAHs) are primarily formed as a result of thermal treatment of food, especially barbecuing or grilling. Contamination by PAHs is due to generation by direct pyrolysis of food nutrients and deposition from smoke produced through incomplete combustion of thermal agents. PAHs are ubiquitous compounds, well-known to be carcinogenic, which can reach the food in different ways. As an important human exposure pathway of contaminants, dietary intake of PAHs is of increasing concern for assessing cancer risk in the human body. In addition, the risks associated with consumption of barbecued meat may increase if consumers use cooking practices that enhance the concentrations of contaminants and their bioaccessibility. Since total PAHs always overestimate the actual amount that is available for absorption by the body, bioaccessibility of PAHs is to be preferred. Bioaccessibility of PAHs in food is the fraction of PAHs mobilized from food matrices during gastrointestinal digestion. An in vitro human digestion model was chosen for assessing the bioaccessibility of PAHs in food as it offers a simple, rapid, low cost alternative to human and animal studies; providing insights which may not be achievable in in vivo studies. Thus, this review aimed not only to provide an overview of general aspects of PAHs such as the formation, carcinogenicity, sources, occurrence, and factors affecting PAH concentrations, but also to enhance understanding of bioaccessibility assessment using an in vitro digestion model.

      • KCI등재

        Cutoff Values of Plasma D-Dimer Level in Patients with Diagnosis of the Venous Thromboembolism after Elective Spinal Surgery

        Saeed Hamidi,Mahdieh Riazi 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.2

        Study Design: A prospective clinical study. Purpose: Our objective in the present study was twofold. First, we sought to evaluate the relationship between postoperative venous thromboembolism (VTE) development and concentration of D-dimer to determine the cutoff value in patients who underwent elective spinal surgery. Second, we identified the predictive risk factors for postoperative VTE. Overview of Literature: VTE affects the general health of patients and may even cause death. Since the complications of VTE are difficult to predict, the safest and most cost effective diagnostic method should be used in order to confirm a suspected VTE event after spinal surgery. Methods: This study was performed on 97 patients who underwent elective spinal surgery. The D-dimer assay was carried out on the day before surgery, and on days 1, 3, and 10 following surgery. VTE occurrence and D-dimer levels were compared between the VTE and the control groups. Results: Four patients (4.1%) were diagnosed with deep vein thrombosis and one patient (1%) was diagnosed with a pulmonary embolism. The optimum D-dimer cutoff value on day 3 following surgery in the VTE group was determined to be more than 2.1 μg/mL with a sensitivity of 100% and a specificity of 80.7%. Moreover, the duration of postoperative recumbency was a significant risk factor for the development of VTE in this study. Conclusions: We have demonstrated that postoperative D-dimer measurements in patients who underwent elective spinal surgery can provide a complementary diagnostic screening for VTE during the first week after surgery.

      • KCI등재

        Covalent Immobilization of Trypsin on a Novel Aldehyde-Terminated PAMAM Dendrimer

        Aliasghar Hamidi,Mohammad R. Rashidi,Davoud Asgari,Ayuob Aghanejad,Soodabeh Davaran 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.7

        Dendrimers are a novel class of nonlinear polymers and due to their extensive applications in different fields, called versatile polymers. Polyamidoamine (PAMAM) dendrimers are one of the most important dendrimers that have many applications in nanobiotechnology and industry. Generally aldehyde terminated dendrimers are prepared by activation of amine terminated dendrimers by glutaraldehyde which has two problems, toxicity and possibility of crosslink formation. In this study, novel aldehyde-terminated PAMAM dendrimer was prepared and used for covalent immobilization of trypsin by the aim of finding a special reagent which can prevent crosslinking and deactivation of the enzyme. For this purpose aminoacetaldehydedimethylacetal (AADA) was used as spacer group between aldehyde-terminated PAMAM and trypsin.The findings of this study showed that immobilization of trypsin not only resulted higher optimal temperature, but also increased the thermal stability of the immobilized enzyme in comparison to the free enzyme.

      • SCIESCOPUSKCI등재

        RESIDUAL SUPERSINGULAR IWASAWA THEORY OVER QUADRATIC IMAGINARY FIELDS

        Parham Hamidi Korean Mathematical Society 2023 대한수학회보 Vol.60 No.4

        Let p be an odd prime. Let E be an elliptic curve defined over a quadratic imaginary field, where p splits completely. Suppose E has supersingular reduction at primes above p. Under appropriate hypotheses, we extend the results of [17] to ℤ<sup>2</sup><sub>p</sub>-extensions. We define and study the fine double-signed residual Selmer groups in these settings. We prove that for two residually isomorphic elliptic curves, the vanishing of the signed 𝜇-invariants of one elliptic curve implies the vanishing of the signed 𝜇-invariants of the other. Finally, we show that the Pontryagin dual of the Selmer group and the double-signed Selmer groups have no non-trivial pseudo-null submodules for these extensions.

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