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Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis
Hajime Fukui,Ayano Chiba,Takahiro Miyazaki,Haruko Takano,Hiroyuki Ishikawa,Naoki Mochiuzki,Toyonori Omori 대한심장학회 2017 Korean Circulation Journal Vol.47 No.2
Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely coordinated by the genetically-primed program that is revealed by the sequential expression of transcription factors. It is important to investigate how spatial allocation of the heart containing cardiomyocytes and other mesoderm-derived cells is determined. In addition, the molecular mechanism underlying cardiomyocyte differentiation still remains elusive. The location of ectoderm-, mesoderm-, and endoderm-derived organs is determined by their initial allocation and subsequent mutual cell-cell interactions or paracrine-based regulation. In the present work, we provide an overview of cardiac development controlled by the germ layers and discuss the points that should be uncovered in future for understanding cardiogenesis.
Hajime Orimo,Masayo Sato,Shuichi Kimura,Keiko Wada,Xuelu Chen,Shigeto Yoshida,Bruce Crawford 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.4
Objectives: This study aimed to identify factors associated with initiation and adherence of osteoporosis medication from a patient perspective. Methods: A web-based survey was developed based on health behavior theories. Descriptive analyses were conducted for all survey items. Analyses in a structural equation modeling framework were conducted to identify factors associated with treatment initiation and adherence. Results: Five hundred forty-five women completed the questionnaire. A majority were currently receiving medications for osteoporosis (n ¼ 376, 69.0%) and 25.0% of these patients (n ¼ 94) were considered adherent to their treatment. Knowledge was strongly associated with osteoporosis treatment initiation (standard error [SE], 0.58). Greater knowledge of disease was associated with increased likelihood of initiating medication. Medication complexity (SE, 0.49) and perceived susceptibility to fracture and loss of independence (SE, 0.37) were also associated with initiation. Perceived barriers (SE, 0.85) such as inconvenience, lack of efficacy and financial burden were observed to be the greatest obstacle to adherence. The greater the perceived barriers, the less likely patients were to adhere to medication. Patients' perception of self-efficacy (SE, 0.37) also affected adherence. The greater the patient perception of ability to independently manage their medication, the more likely they were to adhere to the medication. Conclusions: Different factors were found to be associated with initiation and adherence of osteoporosis medication. Patient knowledge of their disease and the perception of barriers were found to be the most influential. Empowering patients with the knowledge to better understand their disease and decreasing the perception of barriers through education initiatives may be effective in improving patient outcomes. © 2017 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Development of Wave Overtopping–Overflow Transition Model Based on Full-scale Experiments
Hajime Mase,Sooyoul Kim,Makoto Hasegawa,Jae-Hoon Jeong,윤종성 한국해양공학회 2020 韓國海洋工學會誌 Vol.34 No.2
When high waves and storm surge strike simultaneously, the characteristics of the fluid field change drastically from overtopping according to the wave runup height to overflow through a transition state that combines overtopping and overflows. However, an estimation model or evaluation method has not yet been established because there is not enough engineering data. This study developed a wave overtopping-overflow transition model based on a full-scale experiment involving wave overtopping and overflow transition, which appropriately reproduced the effect of waves or the temporal change in inundation flow. Using this model to perform a calculation for the wave overtopping and overflow transition process under typical circumstances, this study determined the wave runup height and features of the inundation flow under time series changes as an example.