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Feeling How Old I Am: Subjective Age Is Associated With Estimated Brain Age
Kwak, Seyul,Kim, Hairin,Chey, Jeanyung,Youm, Yoosik Frontiers Media S.A. 2018 FRONTIERS IN AGING NEUROSCIENCE Vol.10 No.-
<P>While the aging process is a universal phenomenon, people perceive and experience one’s aging considerably differently. Subjective age (SA), referring to how individuals experience themselves as younger or older than their actual age, has been highlighted as an important predictor of late-life health outcomes. However, it is unclear whether and how SA is associated with the neurobiological process of aging. In this study, 68 healthy older adults underwent a SA survey and magnetic resonance imaging (MRI) scans. T1-weighted brain images of open-access datasets were utilized to construct a model for age prediction. We utilized both voxel-based morphometry (VBM) and age-prediction modeling techniques to explore whether the three groups of SA (i.e., feels younger, same, or older than actual age) differed in their regional gray matter (GM) volumes, and predicted brain age. The results showed that elderly individuals who perceived themselves as younger than their real age showed not only larger GM volume in the inferior frontal gyrus and the superior temporal gyrus, but also younger predicted brain age. Our findings suggest that subjective experience of aging is closely related to the process of brain aging and underscores the neurobiological mechanisms of SA as an important marker of late-life neurocognitive health.</P>
곽세열,김근유,박수미,오다영,Hairin Kim,이다솜,이준영 한국임상심리학회 2023 Korean Journal of Clinical Psychology Vol.42 No.4
Previous studies have documented validity evidence of neuropsychological measures in the assessment of dementia. However, known cognitive test measures were mostly validated as separate measurements rather than asconstituents of a whole battery. In this study, the neuropsychological battery (CERAD-K) and neuropsychiatric measures were acquired in older adults with Mild Cognitive Impairment, dementia of Alzheimer’s Disease (AD), and Vascular dementia (VD). The assessment measures and demographic information were used to predict two validity criteria: dementia severity (CDR) and dementia type (AD or VD). A correlation between a single test measure and the target criteria indicated univariate validity, whereas relative impor- tance among multiple regression models indicated the multivariate validity of a single measure as a constituent of the battery. We identified that test measures including the Boston Naming Test, Trail Making Test, and Word List Recall were predictive of the clinical outcome criteria as univariate validity; however, this strength of association did not remain consistent when evalu- ated in terms of multivariate validity. Regarding the multivariate validity, measures including Word List recognition, and neu- ropsychiatric impairment showed robust validity. This contrasting validity indices between univariate and multivariate frame- works may be owing to shared information between other measures, which can distort the conclusions of validity evidence. The findings suggest that the validity of a neuropsychological test differs as a function of the target criteria and whether ad- ministered as a whole battery. The findings suggest that the validity of a neuropsychological measure differs as a function of the criteria of clinical context and whether tested under a comprehensive battery.
곽세열,Shin Seong A,Ko Hyunwoong,Kim Hairin,Oh Dae Jong,Youn Jung Hae,이준영,김유경 대한치매학회 2022 Dementia and Neurocognitive Disorders Vol.21 No.1
Background and Purpose: Verbal and nonverbal fluency tests are the conventional methods for examining executive function in the elderly population. However, differences in impairments result in fluency tests in patients with mild cognitive impairments (MCIs) and Alzheimer’s disease (AD) and in neural correlates underlying the tests still necessitate concrete evidence. Methods: We compared the test performances in 27 normal controls, 28 patients with MCI, and 20 with AD, and investigated morphological changes in association with the test performances using structural magnetic imaging. Results: Patients with AD performed poorly across all the fluency tests, and a receiver operating characteristics curve analysis revealed that only category fluency test discriminated all the 3 groups. Association, category, and design fluency tests involved temporal and frontal regions, while letter fluency involved the cerebellum and caudate. Conclusions: Category fluency is a reliable measure for screening patients with AD and MCI, and this efficacy might be related to morphological correlates that underlie semantic and executive processing.