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Single-crystalline tungsten oxide nanoplates
Deliang Chen,Hailong Wang,Rui Zhang,Lian Gao,Yoshiyuki Sugahara,Atsuo Yasumori 한양대학교 세라믹연구소 2008 Journal of Ceramic Processing Research Vol.9 No.6
Tungsten oxide nanocrystals are important semiconductor materials with a suitable energy band gap (ca. 2.5 eV) for visible-light utilization. Though there are a great amount of reports on the synthesis of WO3 nanocrystals, no effective routes to two-dimensional (2D) WO3 nanocrystals have been reported. We here developed a novel and efficient route to synthesize free-standing single-crystalline WO3 nanoplates on a large scale and in a repeatable way. The proposed route involved a rational transformation of tungstatebased inorganic-organic hybrid nanobelts to single-crystalline WO3·H2O nanoplates, and then to single-crystalline monoclinic WO3 nanoplates with an inhibited crystal growth direction of [004]. The sizes of the as-obtained WO3 nanoplates are (200-500) nm × (200-500) nm × (10-30) nm. The WO3 nanoplates as-synthesized have high specific surface areas (up to 180m2 g−1) and showed remarkably enhanced visible-light photocatalytic properties in water splitting for O2 generation. Tungsten oxide nanocrystals are important semiconductor materials with a suitable energy band gap (ca. 2.5 eV) for visible-light utilization. Though there are a great amount of reports on the synthesis of WO3 nanocrystals, no effective routes to two-dimensional (2D) WO3 nanocrystals have been reported. We here developed a novel and efficient route to synthesize free-standing single-crystalline WO3 nanoplates on a large scale and in a repeatable way. The proposed route involved a rational transformation of tungstatebased inorganic-organic hybrid nanobelts to single-crystalline WO3·H2O nanoplates, and then to single-crystalline monoclinic WO3 nanoplates with an inhibited crystal growth direction of [004]. The sizes of the as-obtained WO3 nanoplates are (200-500) nm × (200-500) nm × (10-30) nm. The WO3 nanoplates as-synthesized have high specific surface areas (up to 180m2 g−1) and showed remarkably enhanced visible-light photocatalytic properties in water splitting for O2 generation.
Hao Jiang,Hailong Tian,Zhihan Wang,Bowen Li,Rui Chen,Kangjia Luo,Shuaijun Lu,Edouard C. Nice,Wei Zhang,Canhua Huang,Yuping Zhou,Shaojiang Zheng,Feng Gao 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Colorectal cancer (CRC) is the second most deadly cancer worldwide, with chemo-resistance remaining a major obstacle in CRC treatment. Notably, the imbalance of redox homeostasis-mediated ferroptosis and the modulation of hypoxic tumor microenvironment are regarded as new entry points for overcoming the chemo-resistance of CRC. Methods Inspired by this, we rationally designed a light-activatable oxygen self-supplying chemo-photothermal nanoplatform by co-assembling cisplatin (CDDP) and linoleic acid (LA)-tailored IR820 via enhanced ferroptosis against colorectal cancer chemo-resistance. In this nanoplatform, CDDP can produce hydrogen peroxide in CRC cells through a series of enzymatic reactions and subsequently release oxygen under laser-triggered photothermal to alleviate hypoxia. Additionally, the introduced LA can add exogenous unsaturated fatty acids into CRC cells, triggering ferroptosis via oxidative stress-related peroxidized lipid accumulation. Meanwhile, photothermal can efficiently boost the rate of enzymatic response and local blood flow, hence increasing the oxygen supply and oxidizing LA for enhanced ferroptosis. Results This nanoplatform exhibited excellent anti-tumor efficacy in chemo-resistant cell lines and showed potent inhibitory capability in nude mice xenograft models. Conclusions Taken together, this nanoplatform provides a promising paradigm via enhanced ferroptosis and alleviated hypoxia tumor microenvironment against CRC chemo-resistance.
Zhu, Kankai,Jin, Hailong,Li, Zhijian,Gao, Yuan,Zhang, Qing,Liu, Xiaosun,Yu, Jiren The Korean Gastric Cancer Association 2021 Journal of gastric cancer Vol.21 No.1
Purpose: This study aimed to investigate the prognostic value of lymph node ratio (LNR) in patients with locally advanced gastric cancer who received neoadjuvant chemotherapy. Materials and Methods: We retrospectively enrolled gastric cancer patients treated with neoadjuvant chemotherapy and curative surgery at the First Affiliated Hospital of Zhejiang University from 2004 to 2015 as the study cohort. Patients with the same inclusion criteria treated in 2016-2017 were enrolled as the validation cohort. Kaplan-Meier curves were assessed using the log-rank test to analyze the differences in overall survival (OS). Multivariate survival analysis was performed using the Cox proportional hazards model. The areas under the receiver operating characteristic curve of ypN and LNR categories for predicting the actual 3-year OS were compared. Results: A total of 265 patients were included in the proposal cohort. The median number of retrieved lymph nodes (rLNs) was 32. The number of positive lymph nodes (pLNs) increased as rLN increased (P=0.037), but the LNR remained relatively constant (P=0.462). The LNR was categorized into 4 groups according to the prognosis: ypNr0, node-negative with rLN>25; ypNr1, node-negative with rLN≤25 or 0<LNR≤0.1; ypNr2, 0.1<LNR≤0.3; and ypNr3, LNR>0.3. In the validation cohort of 43 enrolled patients, there was a clear distinction in OS that significantly (P<0.001) varied depending on the LNR values and LNR was the only independent prognostic factor in multivariate analysis (P<0.001). Conclusions: LNR was an independent prognostic factor for survival of patients with gastric cancer after preoperative chemotherapy and might be an alternative predictor for ypN stage.