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Analytical Performance and Design of CECFST Column Assembled to PEC Beam Joint
Jingfeng Wang,Zhihan Hu,Lei Guo,Bo Wang,Yonggan Yang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7
Concrete-encased concrete-filled steel tube (CECFST) columns and partially encased composite (PEC) beams are both steel-concrete composite members which have outstanding advantages and have been applicated in some engineering constructions. This paper makes an attempt to employ blind bolting technique to assemble CECFST columns to PEC beams. For the purpose of exploring the mechanical performance of this type of assembled joints, firstly, a nonlinear finite element (FE) model was established and validated, where complicated contact interaction was taken into consideration. Plenty of parametric analysis were adopted to find out the effect of ten parameters on strength and initial stiffness of the assembled joint. Numerical analysis showed that mechanic behavior is notably affected by axial load ratio, width and thickness of end-plate, bolt pretension force, bolt diameter, and steel ratio of CECFST column. Full-range analysis was then carried out to observe stress and strain developments and failure modes. Load transfer mechanism in CECFST column was also studied. Design methods to estimate the flexural capacity and initial stiffness of the connections were proposed in accordance with the component models. In comparison, it could be concluded that the calculation results fit well with the analytical results, which confirms that the design formulas could provide a favorable basis in practical design.
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Hao Jiang,Hailong Tian,Zhihan Wang,Bowen Li,Rui Chen,Kangjia Luo,Shuaijun Lu,Edouard C. Nice,Wei Zhang,Canhua Huang,Yuping Zhou,Shaojiang Zheng,Feng Gao 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Colorectal cancer (CRC) is the second most deadly cancer worldwide, with chemo-resistance remaining a major obstacle in CRC treatment. Notably, the imbalance of redox homeostasis-mediated ferroptosis and the modulation of hypoxic tumor microenvironment are regarded as new entry points for overcoming the chemo-resistance of CRC. Methods Inspired by this, we rationally designed a light-activatable oxygen self-supplying chemo-photothermal nanoplatform by co-assembling cisplatin (CDDP) and linoleic acid (LA)-tailored IR820 via enhanced ferroptosis against colorectal cancer chemo-resistance. In this nanoplatform, CDDP can produce hydrogen peroxide in CRC cells through a series of enzymatic reactions and subsequently release oxygen under laser-triggered photothermal to alleviate hypoxia. Additionally, the introduced LA can add exogenous unsaturated fatty acids into CRC cells, triggering ferroptosis via oxidative stress-related peroxidized lipid accumulation. Meanwhile, photothermal can efficiently boost the rate of enzymatic response and local blood flow, hence increasing the oxygen supply and oxidizing LA for enhanced ferroptosis. Results This nanoplatform exhibited excellent anti-tumor efficacy in chemo-resistant cell lines and showed potent inhibitory capability in nude mice xenograft models. Conclusions Taken together, this nanoplatform provides a promising paradigm via enhanced ferroptosis and alleviated hypoxia tumor microenvironment against CRC chemo-resistance.
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