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( Lian Hai Shan ),( Zhen Hong Li ),( Hong Lin Hu ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.1
In recent years, machine-to-machine (M2M) communications are under rapid development to meet the fast-increasing requirements of multi-type wireless services and applications. In order to satisfy M2M communications requirements, heterogeneous networks convergence appears in many areas, i.e., mobile cellular networks (MCNs) and wireless sensor networks (WSNs) are evolving from heterogeneous to converged. In this paper, we introduce the system architecture and application requirement for converged MCN and WSN, where mobile terminals in MCN are acting as both sensor nodes and gateways for WSN. And then, we discuss the joint optimization of converged networks for M2M communications. Finally, we discuss the technical challenges in the converged process of MCN and WSN.
Lian, Hai-Wei,Zhou, Yun,Jian, Zhi-Hong,Liu, Ren-Zhong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: MicroRNAs, small noncoding RNA molecules, can regulate mammalian cell growth, apoptosis and differentiation by controlling the expression of target genes. The aim of this study was to investigate the function of miR-323-5p in the glioma cell line, U251. Materials and Methods: After over-expression of miR-323-5p using miR-323-5p mimics, cell growth, apoptosis and migration were tested by MTT, flow cytometry and cell wound healing assay, respectively. We also assessed the influence of miR-323-5p on the mRNA expression of IGF-1R by quantitative real-time reverse transcriptase PCR (qRT-PCR), and on the protein levels by Western blot analysi. In addition, dual-luciferase reporter assays were performed to determine the target site of miR-323-5p to IGF-1R 3'UTR. Results: Our findings showed that over-expression of miR-323-5p could promote apoptosis of U251 and inhibit the proliferation and migration of the glioma cells. Conclusions: This study demonstrated that increased expression of miR-323-5p might be related to glioma progression, which indicates a potential role of miR-323-5p for clinical therapy.
김홍윤 ( Hong-youn Kim ),김서홍 ( Seu-hong Kim ),박해련 ( Hai-lian Piao ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2
본 논문에서 기존의 치아가공기는 회전하는 모터를 사용하여 구성하였으나 이러한 모터는 정밀도, 반복정밀도가 50um 이하로 가공물 가공시에 치기공사나 치과의사가 사람에 맞추어 다시 작업을 해야하는 불편함과 시간적, 작업자의 피로도를 높일수 있는데 이러한 모터에 스크류나 밸트를 연결하여 선형적으로 움직일 수 있는 리니어모듈과 리니어모터를 적용하게되면 20um수준의 고정밀의 위치 제어가 가능한 5축 치아가공기를 만들 수 있었다. 또한 MEMS센서를 이용하여 스핀들의 상태를 모니터링 하고 임계값을 지정하여 이상 신호 발생시 모터를 멈추어 위험상황에 대해서 인공지능기법을 이용하여 정지하거나 관리자에게 알림을 주어 효과적으로 5축치아가공기를 운영할 수 있도록 하였다.
Wang, Lian-Dong,Gao, Xia,Li, Jun-Ying,Yu, Hong-Yan,Su, Hai-Wen,Liu, Lian-Zhong,Qi, Jun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: To investigate the effects of preemptive analgesia with parecoxib sodium on haemodynamics and plasma stress hormones in surgical patients with thyroid carcinoma. Materials and Methods: Fifty-seven patients with thyroid carcinoma who underwent thyroidectomy selectively in Laiwu Hospital Affiliated to Taishan Medical University and Binzhou People's Hospital were selected and randomly divided into three groups, 19 cases in each group. The control group was intravenously injected 0.9% sodium chloride injection before anesthesia induction; trial group I was intravenously injected with parecoxib sodium 20 min before anesthesia induction; based on trial group I, trial group II was injected with parecoxib sodium again 12 h after surgery. The levels of plasma norepinephrine (NE), cortisol (Cor) and blood glucose before, 12 and 24 h after surgery and changes of haemodynamics before surgery, at the end of surgery and 12, 24 and 48 h after surgery were compared in the three groups. Besides, visual analogue scale (VAS) scores were recorded 4, 8, 12 and 24 h after surgery. Results: 12 and 24 h after surgery, the levels of plasma NE and Cor in three groups rose dramatically (P<0.05 or (P<0.01); The levels of plasma NE and Cor in trial groups I and II were evidently lower than in control group (P<0.05 or P<0.01), and those in trial group II slightly lower than in trial group I. 12 h after surgery, the heart rates (HR) and systolic pressures (SBP) in trial groups I and II increased obviously by comparison to surgery before (P<0.05 or P<0.01), but gradually returned to the preoperative level. HR, SBP and diastolic pressures (DBP) in trial groups I and II at the end of surgery and 12 h after surgery were all lower than in the control group, and significant differences were present (P<0.05 or (P<0.01). At 4, 8, 12 and 24 h after surgery, VAS scores in trial groups I and II were markedly lower than in the control group (P<0.05 or (P<0.01), the scores in trial group II being the lowest. Conclusions: Combined application of parecoxib sodium for preemptive analgesia before anesthesia and after surgery can effectively reduce the levels of plasma stress hormones and improve analgesic effects in surgical patients with thyroid carcinoma, and without conspicuous impact on haemodynamics.
김홍윤 ( Hong-youn Kim ),김서홍 ( Seu-hong Kim ),박해련 ( Hai-lian Piao ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2
본 논문은 기존의 5축 치아가공기나 반도체장비등에 사용하고 있는 회전형 모터의 경우는 엔코더와 리졸버를 사용하고 있다. 엔코더와 레졸버는 고가이므로 실제 산업현장에서 전동기의 위치 센서로는 적용하기가 힘들다. 또한 엔코더와 레졸버와 같은 광학식 위치센서는 그 크기와 내구성에 있어 약점이 있기 때문에 취부 할 때에도 어려움이 있다. 따라서 본 연구에서는 5축치아가공기에 적용하기 위해서 자석가동자를 만들었으며, 이러한 문제점을 해결하는 방안으로 리니어모터를 고정자로 하고 자석플레이트를 이동자로 하는 시스템과 별도의 리니어 스케일을 배제하고 기존의 정현파를 발생하는 2개의 리니어홀센서 및 영구자석을 이용하여 가동자의 절대위치와 이동 위치를 검출할 수 있는 리니어 모터 및 그 제어방법, 안정성 및 신뢰성을 향상시킬 수 있는 자석가동자를 이용하여 구동시 실시간으로 데이터를 확인할 수 있고 제어할 수 있는 모니터링 시스템을 개발하는 연구이다.
김홍윤 ( Hong-youn Kim ),김서홍 ( Seu-hong Kim ),박해련 ( Hai-lian Piao ) 한국정보처리학회 2022 한국정보처리학회 학술대회논문집 Vol.29 No.2
본 논문에서 기존의 혈액투석기는 회전하는 모터를 사용하여 구성하였으나 이러한 모터는 정밀도, 반복정밀도가 50um 이하로 가공물 가공시에 치기공사나 치과의사가 사람에 맞추어 다시 작업을 해야하는 불편함과 시간적, 작업자의 피로도를 높일수 있는데 이러한 모터에 스크류나 밸트를 연결하여 선형적으로 움직일 수 있는 리니어모듈과 리니어모터를 적용하게되면 20um수준의 고정밀의 위치제어가 가능한 혈액투석기를 만들 수 있었다. 또한 MEMS센서를 이용하여 모터의 상태를 모니터링하고 임계값을 지정하여 이상 신호 발생시 모터를 멈추어 위험상황에 대해서 인공지능기법을 이용하여 정지하거나 관리자에게 알림을 주어 효과적으로 혈액투석기를 운영할 수 있도록 하였다.
Jian Son,Hong-Li Wang,Ke-Han Song,Zhi-Wen Ding,Hai-Lian Wang,Xiao-Sheng Ma,Fei-Zhou Lu,Xin-Lei Xia,Ying-Wei Wang,Fei-Zou,Jian-Yuan Jiang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
This study was carried out to explore the roles of circular RNAs (circRNAs) in nucleus pulposus (NP) tissues in intervertebral disc degeneration (IDD). Differentially expressed circRNAs in IDD and normal NP tissues were identified based on the results of microarray analysis. Bioinformatics techniques were employed to predict the direct interactions of selected circRNAs, microRNAs (miR), and mRNAs. CircRNA_104670 was selected as the target circRNA due to its large multiplier expression in IDD tissues. After luciferase reporter and EGFP/RFP reporter assays, we confirmed that circRNA_104670 directly bound to miR-17-3p, while MMP-2 was the direct target of miR-17-3p. The receiver-operating characteristic (ROC) curve showed that circRNA_104670 and miR-17-3p had good diagnostic significance for IDD (AUC circRNA_104670 = 0.96; AUC miRNA-17-3p = 0.91). A significant correlation was detected between the Pfirrmann grade and expression of circRNA_104670 (r = 0.63; p = 0.00) and miR-17-3p (r = −0.62; p = 0.00). Flow-cytometric analysis and the MTT assay showed that interfering with circRNA_104670 using small interfering RNA (siRNA) inhibited NP cell apoptosis (p < 0.01), and this inhibition was reduced by interfering with miR-17-3p. Interfering with circRNA_104670 suppressed MMP-2 expression and increased extracellular matrix (ECM) formation, which were also reduced by interfering with miR-17-3p. Finally, an MRI evaluation showed that circRNA_104670 inhibition mice had a lower IDD grade compared with control mice (p < 0.01), whereas circRNA_104670 and miRNA-17-3p inhibition mice had a higher IDD grade compared with circRNA_104670 inhibition mice (p < 0.05). CircRNA_104670 is highly expressed in the NP tissues of IDD and acts as a ceRNA during NP degradation.
Hui-Xian Yan,Hai-Lian Hong,Lian-Hui Zheng,Heng-Di Su 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.7
Due to ionic migration and adsorption, an electrical double layer with a thickness scaled by the Debye length is formed at the hydrogel-solution interface. For a thin temperature-pH dual sensitive hydrogel whose chickness is comparable to the Debye length, its mechanical behavior may be affected by the electrical double layer. In this paper, by incorporating electromagnetic field theory into thermodynamic theory, we develop a coupled field theory for a temperature-pH dual sensitive hydrogel, and we take into account the electrical double layer. The proposed model can be used to analyze the in uences of the size effect, ionic concentration, ambient temperature and solution pH value on the swelling of a thin layer of the temperature-pH sensitive hydrogel.
Shen-Ping Xiao,Hong-Hai Lian,Hong-Bing Zeng,Gang Chen,Wei-Hua Zheng 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.5
This paper investigates the robust delay-dependent passivity problem of neural networks (NNs) with time-varying delays and parameter uncertainties. A suitable augmented Lyapunov-Krasovskii functional (LKF) with triple integral term, which takes full use of the neuron activation function conditions and the information of time-delay in integral term, is constructed. Furthermore, by utilizing integral inequality proposed recently and the combining reciprocally convex method to estimate the derivative of the LKF, some less conservative robust passivity conditions are derived in terms of LMI. The superiority of presented approaches are demonstrated via two classic numerical examples.