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Vaccination and Complementary and Alternative Medicine in Patients with Inflammatory Bowel Disease
( Sung Bae Kim ),( Soo Jung Park ),( Sook Hee Chung ),( Kyu Yeon Hahn ),( Do Chang Moon ),( Sung Pil Hong ),( Jae Hee Cheon ),( Tae Il Kim ),( Won Ho Kim ) 대한장연구학회 2014 Intestinal Research Vol.12 No.2
Background/Aims: Vaccinations in patients with inflammatory bowel disease (IBD) are recommended to prevent infectiousdiseases. However, there are few reports of vaccination in IBD patients in Korea. The frequency of complementary and alternativemedicine (CAM) use is high despite its uncertain effectiveness. This study aimed to identify the rates of vaccination anduse of CAM in patients with IBD. Methods: A total of 219 patients attended an education session for IBD patients held at SeveranceHospital on March 23, 2013. We conducted a survey on vaccination and CAM use in IBD patients; 120 patients completedthe questionnaire. Results: The influenza vaccination rate was 44.2% and pneumococcal vaccination rate was 4.2%. Thirtyone(66%) patients were aware of the importance of vaccination. The vaccination rate was higher in patients who were awareof the importance of vaccination compared with that in patients who were unaware of the importance of vaccination (70.1%vs. 41.7%, P =0.004). The rate of CAM use was 30.0%. The most commonly used CAMs were oral products: vitamins (33.3%),red ginseng (25.0%), and probiotics (19.4%). Conclusions: Awareness of the importance of vaccination and actual vaccinationrates were low in IBD patients. Despite insufficient evidence on the effectiveness of CAMs in IBD patients, many patients usedCAMs. We believe that repeated education and promotion of vaccination are important. Further large-scale studies to investigatethe efficacy and safety of CAMs are warranted in patients with IBD. (Intest Res 2014;12:124-130)
Hahn, Kyu Yeon,Park, Chan Hyuk,Lee, Yong Kang,Chung, Hyunsoo,Park, Jun Chul,Shin, Sung Kwan,Lee, Yong Chan,Kim, Hyoung-Il,Cheong, Jae-Ho,Hyung, Woo Jin,Noh, Sung Hoon,Lee, Sang Kil Springer-Verlag 2018 Surgical endoscopy Vol.32 No.1
<P>Although EGC lesions had poorer features in the surgery group than in the ESD group, ESD was comparable to surgery for EGCs that fulfilled the expanded indication of ESD, with lower rates of acute complication and comparable overall survival.</P>
Flexible wireless powered drug delivery system for targeted administration on cerebral cortex
Sung, Sang Hyun,Kim, Young Soo,Joe, Daniel J.,Mun, Beom Ho,You, Byoung Kuk,Keum, Do Hee,Hahn, Sei Kwang,Berggren, Magnus,Kim, Daesoo,Lee, Keon Jae Elsevier 2018 Nano energy Vol.51 No.-
<P><B>Abstract</B></P> <P>The controlled drug delivery devices helps timely drug administrations and maintenance of effective dose to maximize curing effects with minimal side effects. Application of this technology to various body parts has been limited, especially in organs with curved surface, such as the brain and the eye. Herein, we report a flexible drug delivery microdevice (f-DDM) for controlled administration on the curved organ surface. The unique structure of the f-DDM consists of freestanding gold membranes over the multireservoir array was implemented by reversing the typical fabrication order of the reservoir and sealing membrane. We optimized the design of the f-DDM by a finite element analysis to prevent thermal damage during the laser transfer and the applying current density for reliable drug release through an electrochemical analysis. The wireless power transfer system was applied to f-DDM, which shows stable wirelessly powered operation. The f-DDM was flexible enough to be implantable on the curved cerebral cortex and successfully adopted for delivery of two different chemicals or prevention of seizure activity using an anti-epileptic drug. Our study opens a new avenue for the controlled, region-specific, and combinatorial application of drugs, the key factors for precision medicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The flexible drug delivery microdevice with controlled release was fabricated by laser-lift off technique. </LI> <LI> The f-DDM was able to operate with wireless power transfer system in near-field range. </LI> <LI> The f-DDM was implanted to the brain of live mice for the localized administration to the cerebral cortex. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Carpal Tunnel Syndrome Caused by Space Occupying Lesions
Ho Jung Kang,Sung Hoon Jung,윤홍기,Soo Bong Hahn,Sung Jae Kim 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.2
Purpose: To evaluate the diagnosis and treatment of the carpal tunnel syndrome (CTS) due to space occupying lesions (SOL). Materials and Methods: Eleven patients and 12 cases that underwent surgery for CTS due to SOL were studied retrospectively. We excluded SOL caused by bony lesions, such as malunion of distal radius fracture, volar lunate dislocation, etc. The average age was 51 years. There were 3 men and 8 women. Follow-up period was 12 to 40 months with an average of 18 months. The diagnosis of CTS was made clinically and electrophysiologically. In patients with swelling or tenderness on the area of wrist flexion creases, magnetic resonance imaging (MRI) and/or computed tomogram (CT) were additionally taken as well as the carpal tunnel view. We performed conventional open transverse carpal ligament release and removal of SOL. Results: The types of lesion confirmed by pathologic examination were; tuberculosis tenosynovitis in 3 cases, nonspecific tenosynovitis in 2 cases, and gout in one case. Other SOLs were tumorous condition in five cases, and abnormal palmaris longus hypertrophy in 1 case. Tumorous conditions were due to calcifying mass in 4 cases and ganglion in 1 case. Following surgery, all cases showed alleviation of symptom without recurrence or complications. Conclusion: In cases with swelling or tenderness on the area of wrist flexion creases, it is important to obtain a carpal tunnel view, and MRI and/or CT should be supplemented in order to rule out SOLs around the carpal tunnel, if necessary.