외음부와 자궁에 생긴 평활근종 1예

박혜인,이해혁,김태희,김정식,남계현,이권해,고은석 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The leiomyomas of the vulva are rare benign tumors the incidence is 0.024%~0.55% in women. There are no relationship between leiomyomas of the vulva and uterus. But there are some reports that leiomyomas of the vulva and uterus simultaneously. The leiomyomas of the vulva present without symptoms and excision with biopsy is treatment of choice. Tumors of the gynecological apparatus may present without symptoms, or they may mimic other common gynecological conditions. Because of this, any vulva mass must be considered cautiously. We reported this case with a brief review of the concerned literatures.

독해력 신장을 위한 독해전략 실험 연구 : Centered on Middle School 3 중학교 3학년을 중심으로

송석요,박해순 서원대학교 교육연구소 2000 敎育發展 Vol.19 No.2

The purpose of this study is to find a way for teaching English reading comprehension to the students of English as a foreign language in Korea and to develop a teaching model for reading comprehension in reading classes. To achieve this purpose, this study was conducted according to the following procedure : (1) Based upon theoretical background and the survey of the English reading strategies, the main experimental study was conducted form March 1999 to December 1999. Two groups of students were selected from the subjects on the basis of test scores. One was the experimental group, 34 students and the other was the comparative group, 32 students. (2) The subjects of the comparative group were presented by traditional methods based on bottom-up process when they studied the main text. But those in the experimental class were instructed through reading strategies. (3) At the end of this work each student had a test. The test was composed of 25 items, 25 minutes, and 25 scores in each. The problems were made up of searching topics, main ideas, organization of passage and inference. The result analyses were shown as follows; (1) The questionnaire reported that almost all the students focused on word power, but neglected reading strategies. So they lost their interest in general English reading activities. (2) The experimental group had higher total comprehension scores, which showed reading strategies were significantly more effective than the comparative. (3) 4 reading strategies (previewing, predicting, scanning, skimming) demonstrated a greater effect in developing the reading comprehension ability of students. Some implications could be drawn from the results of this study; (1) In English reading classes, students could be presented different effective strategies on paragraph levels of the text and practice those strategies to the full use. (2) Students could recognize the importance and utility of reading strategies and do exercises through train to learn and develop their own effective strategies for successful reading.

대학생 학습과정 조사도구의 비교·분석 연구

신현석,변수연,박해경 한국교육방법학회 2012 교육방법연구 Vol.24 No.1

Higher education institutions in the 21st century are feeling more and more pressure to show and prove their due accountability toward the society. The fulfillment of their social responsibilities can be accomplished by teaching and research. The quality of teaching in higher education institutions have been approached from various perspectives and tried to be measured by different methods. Among others, students' evaluation and ratings have been viewed as useful tools to evaluate the quality of education and supporting services of the institutions. This study analyzed 5 aspects of the three major student's evaluation and engagement questionnaires: National Survey of Student Engagement, Course Experience Questionnaire, Australian Survey of Student Engagement. In comparative analysis, researchers concluded CEQ has several shortcomings to be an efficient and effective student engagement scale while it still has some merits such as offering a opportunity to every college graduate to evaluate their college teaching experience. NSSE and AUSSE, taking the sample study framework, are reviewed to be easier to be administrated and contain more plentiful information about various facets of college students' experience and its relationship with achievements in college. This findings are expected to offer useful implications to those who develop the Korean scale of student experience and engagement. 본 연구는 세계적으로 사용되고 있는 대학생 학습과정 조사도구들 중 NSSE, CEQ, AUSSE의 개발 배경과 변천 과정, 개발 목적, 주요 내용, 결과의 활용 다섯 가지 측면을 조사한 후 이를 비교․분석함으로써 우리나라 고등교육기관의 대학생 학습과정 조사도구 개발을 위한 정책적 시사점을 제안하는 것을 목적으로 한다. 이들을 비교한 결과 다섯 가지 준거를 통한 비교․분석 결과 대학 강의 경험을 주요 내용으로 하는 전수조사 방식의 CEQ보다는 강의와 강의실 밖의 다양한 학습 기회에 대한 학생 참여도를 기준으로 대학생의 학습과정과 대학 교육의 질을 평가하는 표본조사 방식의 NSSE와 AUSSE가 우리의 고등교육 시스템에 더 적합할 뿐만 아니라 국제적 비교․분석도 가능한 조사도구로 평가되었다.

산도가 장관의 운동성에 미치는 영향

장석종,박해근,김광진,임현재 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.2

The effects of hydrogen ion concentration changes on the motility as well as patterns of motility to autonomic drugs was investigated in the isolated duodenum and ileum of rabbits. Motility was recorded on a Physiograph with force transducer by means of Magnus method in sodium lactate Ringer's solution at 37℃ The pH of the Ringer's solution used were nornal (pH 7.4), acidic (7.4-5.5), and alkaline(7.4-9.5), titrated by 0.01 N BCI or 0.01 N NaOH solution respectively. Acetylcholine and norepinephrine as autonomic drugs was treated at normal, acidic, and alkaline Ringer's solution. Obtained results may be summarized as follows. 1. Increased hydrogen ion concentration (or decreased pH) inhibited tie motility of duodenum and ileum and that was proportional to increment of hydrogen ion concentration. 2. Decreased hydrogen ion concentration(or increased pH) enhanced the motility of duodenum and ileum and that at was proportional to decrement of h drocen ion concentration. 3. Effect of acetvlcholine on the patterns of motility in duodenum and ileum was not altered by hydrogen ion concentration changes. 4. Effect of norepinephrine on the patterns of motility in duodenum and ileum was not altered by hydrogen ion concentration changes.

심실근의 수축현상에 미치는 O₂, CO₂ 및 pH의 영향

장석종,박해근 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

It has been well known that increased hydrogen ion concentration causes the negative inotropic effect on the heart. But in the status of acid base imbalance, metabolic or respiratory, the question of which status has more profound effect on the cardiac muscle contractility remains unsolved. Furthermore, whether such effect is attributable to the change of the intracellular pH or the extracellular change is a matter of controversy. In many studies concerning to the effect of carbon dioxide tension on the cardiac contractility, the effect of excess oxygen has been ignored despite of its significant influence upon the cellular function. The author intended to investigate the effects of the change of carbon dioxide tension, which causes the pH change simultaneously, as well as the effect of excess oxygen on the cardiac ventricular contractility. Also, to prove which change, metabolic or respiratory, has more profound effect and which change, intracellulcr or extracellular, has more crucial effect, the author examined the contractility of the ventricle under two different conditions. They were as follows: a) PCO_2 was varying despite of same magnitude of the change in pH. b) pH was varying despite of the same magnitude of the change in PCO_2 Turtle hearts were used and the Langendorf preparations were made. The perfusate was Tris-buffer solution for turtle, saturated with various gases, such as air, pure oxygen, nitrogen, or different concentrations of CO_2 balanced with oxygen or nitrogen. The tension and maximal dT/dt were recorded with the Physiograph and its accessories. The results were summarized as follows. 1. The excess oxygen enhanced the ventricular contractility. 2. Increased carbon dioxide tension, which decreases the pH simultaneously, reduced the ventricular contractility and that was more pronounced when CO_2 was balanced with nitrogen gas rather than with oxygen gas. 3. The relationships among several physiological parameters were estimated as follows: a) Y=1.01X-0.56 X: percent change of the tension Y: percent change of maximal contration dT/dt b) Z=1.06X-4.56 Z: percent change of maximal relation dT/dt The corelation coefficient in a) is 0.939 and in b) is 0.926, being significant statistically (P<0.005). 4. When the change of pH were same but the changes of PCO_2 were different, the change of ventricular contractility was more profound in the respiratory decrease of pH, that was higher PCO_2, more depressing effect (P<0.005) was manifested, than in the case of metabolic origin (p<0.005). 5. When the changes of PCO_2 were same but the changes of pH were different, the influence of the latter parameter on the contractility was not significant (P<0.1). From the above results it was suggested that the increased PCO_2, which also causes the decrease of pH, has negative inotropic effect and excess oxygen has positive inotropic effect on the ventricular muscle of the turtle. The negative inotropic effect of the lowered pH on the ventricular muscle was revealed to be more profound when it was induced by respiratory distress rather than motabolic and may be affected by change of intracellular pH rather than extracellular pH.

심첨부 비후 심근증에서 심근 내 미세 관상동맥의 혈류 예비력 평가 : 경흉부 도플러 심초음파를 이용한 연구 Study Using Transthoracic Doppler Echocardiography

윤호중,박철수,신재원,임상현,조은주,정해억,전희경,오용석,정욱성,김재형,최규보,홍순조 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

유산균(L.lactis CBT-8)및 발효 추출물의 Helicobacter pylori 억제 능력

진춘조,박형석,이혜운,김성렬,강동구,이준상,이재동,왕준호 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers(30-49 yr)were randomized into two groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0±4.9 before, 15.3±2.1 after treatment)(p<0.05). the DOB30 of group B(n=13) was decreased 22.3% after treatment(22.0±2.2 before, 17.1±1.7 after treatment)(p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.

사람 위선암에서 cathepsin L의 발현증가

홍원선,홍석일,박인철,손영숙,정훈용,양석균,김해련,민영일 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1

cathepsin L은 lysosomal cysteine 단백분해효소로서 기저막(basement membrane)과 세포외기질(extracellular matrix)을 파괴하여 암세포의 침윤과 전이에 중요한 역할을 하는 물질로 알려져 있다. 이러한 cathepsin L에 대한 mRNA 발현도를 5개의 사람 위선암(gastric adenocarcinoma) 세포주와 5명의 위선암 환자에서 채취한 조직에서 방사능으로 표지된 cathepsin L특이 cDNA를 사용한 Northern blot법으로 측정하였다. 위암의 전이병소에서 수립한 세포주인 SNU-5, SNU-16, MKN-45와 Kato Ⅲ에서는 cathepsin L mRNA가 발현되었으나 원발병소에서 수립한 AGS 세포주에서는 mRNA의 발현이 관찰되지 않았다. 5명의 위암 환자에서는 원발병소, 전이가 확인된 임파절 및 암 근처 정상 위점막에서 각각 조직을 채취하여 cathepsin L mRNA의 발현을 측정하였다. 원발병소와 전이병소에서는 모두 cathepsin L mRNA가 발현되었으나 정상 위점막조직에서는 전예에서 mRNA 발현이 관찰되지 않았다. 한편 mRNA의 발현도는 1예에서는 전이병소가 원발병소에 비해 높았으나, 2예에서는 전이병소에서 발현도가 낮았으며, 나머지 2예에서는 원발병소와 전이병소 사이에 차이가 없어, 원발병소와 전이병소 사이에 mRNA의 발현도의 일관성 있는 경향은 관찰되지 않았다. 이상의 결과는 cathepsin L은 위암의 발생과 진행에 있어 암세포의 침윤과 전이를 촉진하는 것 이외에 또 다른 역할을 할 가능성을 시사하고 있다고 사료된다. Cathepsin L, a lysosomal cysteine protease, is known to play an important role in cancer invasion and metastasis by degrading the components of basement membrane and extracellular matrix. The mRNA expression of cathepsin L was determined by Northern blot analysis using a radiolabeled cDNA specific for cathepsin L in five human gastric adenocarcinoma cell lines and five surgical specimens of primary gastric adenocarcinomas, their metastatic lymph nodes and matched adjacent normal mucosae. The mRNA of cathepsin L was expressed in all of the four cell lines established from the metastatic sites, SNU-5, SNU-16, MKN-45 and Kato Ⅲ, while not detected in one cell line established from the primary site, AGS. The mRNA was expressed in all of the five primary and five metastatic cancer specimens tested, while it was not detected in all matched normal mucosae. The intensities of the mRNA expressions, however, did not show the consistent pattern between primary sites and metastatic lymph nodes. These results suggest that cathepsin L may have the other function in addition to facilitation of the invasion and metastasis during the development and progression of stomach cancer.

원발성 위 소세포암 1례

윤상애,전혜정,함희원,박형석 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

Small cell carcinoma originates from APUD cell of any part of the body. Usually the cases are discovered in the lung, and have poor prognosis. Primary small cell carcinoma of the stomach has been recognized recently, and only three cases have been reported in the Korea. This tumor is morphologically analogous to small cell carcinoma of the lung, and characterized by very aggressive clinical course. We report a case of primary small cell carcinoma of the stomach which had hepatic metastasis. The lesion of the stomach, located in the upper body and cardia, is ulcerated with irregular margin and dirty surface covered with exudates.

미세 가공된 정전용량형 초음파 탐촉자의 막 운동 모델링 및 분석

김기복,안봉영,박해원,김영주,김국진,이승석 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

In this study, theoretical analysis and finite element analysis of the behavior of membrane (such as resonance frequency, membrane deflection, collapse deflection and collapse voltage)in thc capacitive micromachined ultrasonic transducer (cMUT) were performed. The design parameters of the cMUT were estimated and are the dimension and thickness of membrane, thickness of sacrificial layer, thickness and size of electrode, size of active element and so on. The resonance frequency of the membrane increased as the thickness of the membrane increased but decreased as the diameter of the membrane increased. The deflection of the membrane increased as d-c bias voltage increased. The collapse voltage of the membrane was predicted.