http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
KIM, Rung-Gyu,SHIN, Kyung-Min,KIM, Young-Kwan,JEONG, Hyeh-Jean,HA, Joohun,CHOI, Jong-Won,PARK, Hee-Juhn,LEE, Kyung-Tae WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
As an attempt to search for bioactive natural products exerting antunflammatory activity, we have evaluated the effects of the methanol extract from the aerial parts of Saururus chinensis (LouR.) BaILL (Saururaceae) on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E_(2)(PCE_(2)) release by the macrophage cell line RAW 264.7. Our data indicate that this extract is a potent inhibitor of NO production and it also significantly decreased PGE_(2) release. Consistent with these observations, the protein and mRNA expression level of inducible NO synthase ((1)_NOS) and cyclooxyagenase (COX)-2 was inhibited by MeOH extracts of the aerial part of S chinensis (SCM) in a dose-dependent manner. Furthermore, SCM inhibited the LPS-induced DNA binding activity of nuclear factor-kB (NF-kB), which was associated with decreased p65 protein levels in the nucleus. These results suggest that SCM inhibits LPS-induced (1)_NOS and COX-2 expression by blocking NF-kB activation.