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Detection of p16 Gene Alteration in Cervical Cancer Using Tissue Microdissection and LOH Study
Park, Jong-Sup,Dong, Seung-Myung,Kim, Hy-Sook,Lee, Jung-Young,Um, Soo-Jong,Park, In-Seo,Kim, Seung-Jo,Namkoong, Sung-Eun 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
The p16 gene was identified as cyclin-dependent kinase inhibitor (CDKI) and this may negatively regulate the cell cycle by acting as a tumor suppressor. Using tissue microdissection, the molecular changes at p16 and Rb genes were analysed in the spectrum of disease from dysplasia to invasive cancer of the uterine cervix. Six of 27 (22%) cases informative for D9S171 and IFNA of 9p 21-22 marker (p16INK4a) showed loss of one or both alleles in at least one of these loci. HOH of pRb was detected in 29% (5/17). Gene alterations at p16 and pRb loci were only detectable in some cases of HPV-16/18 DNA positive cervical cancer. Three cases demonstrated mutational changes of p16INK4a, and the alterations were determined to be G to T shift, suggesting transitional missense mutation. In summary, the inactivation of the p16/cdk-cyclin/Rb cascade may play an additional role during the malignant progression in HPV-16/18 positive cervical cancers. 1999 Elsevier Science Ireland Ltd. All rights reserved. (Cancer Letters 136:101-108, 1999)
Methotrexate 투여한 침윤천공-전치태반 1 례
박정희,고덕영,홍경희,이준형,박종두,김형용,박현중 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9
Placenta previa-percreta is a rare but highly morbid condition usually diagnosed clinically, intraoperatively. The cause of placenta accreta is considered to be deficient decidualization and absence of the fibrinous layer of Nitabuch. The condition is usually, but not always, seen in women having previous trauma, eg, cesarean section, manual removal of placenta, or curettage. Magnetic resonance imaging(MRI) might allow antepartum diagnosis of the this condition. Management included cesarean supracervical hysterectomy and bilateral hypogastric arterial ligation, and adjuvant methotrexate administration. We experienced a case of placenta previa percreta at 40 weeks gestational age. Here we present the case with brief review of literature.
JY Park,AR Kim,SY Yoo,JI Kim,TW Jung,SH Woo,HY Heo,TW Kim,TS Ko 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Excessive water stress can cause severe damage to sorghum and results in significant yield reduction. The aim of this study is to identify quantitative trait loci (QTL) for excessive water stress in sorghum. As a first step, two out of 21 bmr mutants were selected for their superior agronomic performance and Chlorophyll a fluorescence OJIP transient, and were crossed with an elite Korean cultivar, Hwangkeumchal, to construct mapping populations. One hundred ten out of 236 SSR primers showed polymorphism between two parens, which cover ten chromosomes of sorghum from different published SSR linkage maps of sorghum. Development of recombinant inbred lines from the crosses ‘25M2-0698 x Hwangkeumchal’ and ‘25M2-0404 x Hwangkeumchal’ are in progress using the single seed descendent method for generation acceleration.
박헌엽(HY Park) 대한산부인과학회 1965 Obstetrics & Gynecology Science Vol.8 No.12
A case of pulmonary metastasis of cervical cancer is presented. A 43-year-old, cervical cancer, Stage Ⅰ, infiltrating squamous cell carcinoma, was treated by Radical hysterectomy (Wertheim type) and Cesium-137 external irradiation, After ten months, of primary treatment vaginal metastasis occurred, treated by intravaginal Radium application. And then thirteen months later pulmonary metastasis occurred. A brief review of the literature was done.
정행용(HY Chung),신승권(SK Shin),박주현(JH Park),박헌정(HJ Park) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.11
임신 39주로 제왕절개술로 만출된 구진파열을 동반한 흉복부유합기형아 1예를 경험하였기에 해부학적 소견 및 문헌적 고찰을 보고하는 바이다. A case of 39th week of gestation thoracopagus, combined with cleft palate, delivered by cesarean section, is reported with a brief review of the related literatures.