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Dual Roles of Pin1 in Cancer Development and Progression
Han, Hyeong-jun,Choi, Bu Young,Surh, Young-Joon Bentham Science 2017 Current pharmaceutical design Vol.23 No.29
<P>Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary.</P>
CNG 혼소율 변화에 따른 디젤엔진의 성능 및 연소 특성에 관한 연구
장형준(Hyeong-Jun Jang),이선엽(Sun-Youp Lee),김창기(Chang-Gi Kim),조정권(Jeong-Kwon Cho),임종한(Jong-Han Lim),윤준규(Jun-Kyu Yoon) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.5
전 세계적으로 천연가스 시장에서는 천연가스의 저열량화 추세로 뚜렷하게 변화되고 있다. 이러한 추세는 국내의 천연가스 열량기준에 변화를 가져왔으며, 낮은 열량의 천연가스 도입으로 인해 현재 사용되고 있는 가스기기의 성능에도 변화가 있을 것으로 예측된다. 따라서 본 연구에서는 혼소엔진의 연소특성을 파악하기 위해 CNG 혼소율 변화를 이용하여 열효율, 도시평균유효압력 변동계수 및 열방출 특성을 고찰하였다. CNG 혼소율은 투입되는 연료의 총합 대비 공급되는 천연가스연료의 에너지로 계산하여 천연가스연료가 디젤연료를 대체하는 비율로 정의하였다. 엔진 실험조건으로는 공급되는 천연가스의 발열량은 10,400 ㎉/N㎥이며, 1800 rpm/500 N·m의 엔진 운전조건에서 디젤연료의 분사시기는 BTDC 16°CA, 분사압력은 85 ㎫로 설정하여 엔진의 성능 및 연소 실험을 진행하였다. 엔진 실험결과로 CNG 혼소율이 변화함에 따라 공급되는 디젤 연료량 역시 변화하고, CNG 혼소율이 증가할수록 디젤 연료량이 감소함으로써 점화에너지가 줄어들어 점화지연기간이 길어지는 연소특성을 나타내며, 이로 인해 엔진의 열효율과 출력도 감소하는 경향을 보였다. 그러나 연소안정성은 5% 미만으로 안정적인 엔진의 연소상태를 보여 실험의 신뢰성을 확보할 수 있었다. In the international natural gas market, natural gas has markedly low calories. The domestic calories standard of natural gas was changed and the performance and efficiency of many industrial machines using natural gas were affected because of low caloric natural gas. Therefore, in this study, a dual fuel engine fueled with natural gas and diesel was tested to examine the effects of the CNG substitution rate on the combustion characteristics, such as thermal efficiency, COVimep and heat release rate. The CNG substitution rate was defined as the ratio of CNG instead of diesel, which was calculated as the total energy. The conditions of the tested engine were fixed 1800 rpm/500 N·m. In addition, diesel fuel was injected at 16°CA BTDC and the fuel pressure was fixed at 85 ㎫; the lower heating value of CNG was 10,400 ㎉/N㎥. The results of the engine test showed that the amount of diesel fuel was changed according to the CNG substitution rate. Therefore, when the substitution rate was increased, the amount of diesel fuel was decreased, which affected the energy for ignition. In addition, the ignition delay duration was increased, which affected the thermal efficiency and torque. On the other hand, the COVimep was less than 5% and a stable combustion state of the engine was shown.
Analysis of Sexed Sperm by Flow Cytometry in Hanwoo (Korean Native Cattle)
Yoo, Han-Jun,Lee, Kyung-Jin,Lee, Yong-Seung,Yoon, Pil-Sang,Park, Joung-Jun,Kim, Hyeong-Cheol,Park, Choon-Keun The Korean Society of Animal Reproduction 2012 Reproductive & developmental biology Vol.36 No.1
This study evaluated a sexed sperm ability to produce embryos by flow cytometer. Hanwoo bulls sperm were separated to X and Y sperm via Hoechst 33342 stained with near UV laser or performed the pre-sorted without near UV laser beam in flow cytometry. Pre-sorted sperm had significantly higher viability ($84{\pm}1.15%$, $p$<0.05) compared to other sorted groups in frozen-thawed semen. For fresh semen, pre-sorted sperm had the higher viability ($79{\pm}3%$, $p$<0.05) than those of the X and Y sperm ($44.7{\pm}1.67$ and $41.7{\pm}1.2%$) separated by differences of DNA content. On the other hand, pre-sorted and X sperm sorted according to differences in DNA content had significantly higher viabilities ($24.3{\pm}1.2$ and $25.7{\pm}0.9%$, $p$<0.05) compared to that of the sorted Y sperm ($13.7{\pm}1.2%$) in the hypoosmotic swelling test. The proportion acrosome reaction in the sorted X sperm was higher ($55.0{\pm}1.7$ and $45.0{\pm}1.5%$) than those of the sorted Y-sperm ($32.3{\pm}0.9%$, $p$<0.05). However, the sperm morphologies of the sorted groups were not significantly differences. In conclusion, the sex-sorting procedure by flow cytometry affected some characteristics of Hanwoo sperm. Further study is needed to determine the optimal procedures to enhance male and female embryos and sorting accuracy.
한형수 ( Han Hyeong Su ),김준욱 ( Kim Jun Ug ),서관식 ( Seo Gwan Sig ),김종순 ( Kim Jong Sun ),유형준 ( Yu Hyeong Jun ),박효숙 ( Park Hyo Sug ) 대한내과학회 1990 대한내과학회지 Vol.38 No.1
N/A Thyroid Hemiagenesis is a congenital anomaly of the thyroid gland. The incidence of thyroid hemiagensis is unknown, but it is very rare. We found the first case of thyroid hemiagenesis in Korea. In this case, the left lobe was absent and the right lobe with isthmus was present. A technetium image revealed a normally appearing right lobe and an isthmus with a hockey-stick configuration. The associated disease in the remaining thyroid lobe was chronic lymphocytic thyroiditis. She was found to be in a euthyroid state without abnormalities. We report a case of thyroid hemiagenesis in a 54 year-old female patient with a review of the literatures.
파라핀 표면코팅을 적용한 과립형 지연제를 사용한 모르타르의 응결 특성
김준형 ( Kim Jun Hyeong ),이준석 ( Lee Jun Seok ),이승엽 ( Lee Seung Yeop ),최수호 ( Choi Su Ho ),김한샘 ( Kim Han Saem ),류재석 ( Ryou Jae Suk ) 한국구조물진단유지관리공학회 2017 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.21 No.1
In this study, Retarder, which shows characteristics of delay hydration reaction and reduce hydration heat in concrete, was processed through granulation and paraffin coat to induce reaction by hydration heat. The prepared paraffin coated granular retarder was mixed with the mortar and the setting time was measured according to the desired temperature. As a result, it was confirmed that paraffin coated granular retarder which does not react during the concrete placing exhibits performance depending on the temperature.
Ji Hee Han,Hyeong Gyeong Kim,Hun Tae Lim,Jeong Jun Kim,SangYeob Lee 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
Beet armyworm, Spodoptera exigua are difficult to control using chemical insecticides because of the development of insecticide resistance. For eco-friendly beet armyworm managements, various control agents are required. Entomopathogenic fungus is one of promise control agents as an alternative to chemical control agent. We isolated entomopathogenic fungi from soil samples of suwon by insect-bait method using Galleria mellonella and conducted bioassay to larva of beet armyworm. As a result of bioassay isolate FG274, FG340, FG344 had high virulence as 100% against second instar larva of S. exigua. To identify the fungus isolates, their’s morphological characteristic was observed and ITS of 18srRNA was sequenced. ITS sequence of FT274, 340, 344 were highly matched (100%) to that of Beauveria bassiana, Paecilomyces fumosoroseus, Metarhizium anisopliae. To investigate the optimal concentration, three isolates were sprayed at three different concentration(1×106 ,107 and 108 conidia/㎖) in laboratory conditions. 나타내었다.
Ji Hee Han,Jeong Jun Kim,Sang Yeob Lee,Hyeong Gyeong Kim 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
Beet armyworm, Spodoptera exigua are difficult to control using chemical insecticides because of the development of insecticide resistance. For eco-friendly beet armyworm managements, various control agents are required. Entomopathogenic fungus is one of promise control agents as an alternative to chemcal control agent. We conducted bioassays with entomopathogenic fungi to select high virulence isolate to larva of beet armyworm. The bioassay was used 150 entomopathogenic fungal isolates which were isolated from soil samples of nine provinces by insect-bait method using Galleria mellonella and Tenebrio molitor. . Three isolates, Metarhizium spp. FT83, FT89 and FT90 had high virulence as 84.6%, 100% and 100%, respectively, against S. exigua. The medial lethal time(LT50) of conidia of three isolates was 5.01, 2.99 and 2.92days respectively.
Ji Hee Han,Hyeong Gyeong Kim,Jeong Jun Kim,Sang Yeob Lee 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.04
Beet armyworm, Spodoptera exigua is difficult to control using chemical insecticides because of the development of insecticide resistance. Various control agents may use for eco-friendly beet armyworm managements, Entomopathogenic fungus is one of the promising control agents as an alternative to chemical control agent. At previous study we isolated a number of entomopathogenic fungi from soil samples and selected three entomopathogenic fungi, Metarhizium anisopliae FT83, Paecilomyces fumosoroseus FG340 and Metarhizium anisopliae FG344 which had high virulence against larva of beet armyworm. To select an isolate having high virulence at high temperature against S. exigua, thermophilic pest, we conducted bioassay at five different temperatures(15, 20, 25, 30, 35℃). These three isolates showed the high mortality and low LT50 at 30℃. To select substrate for mass production these isolates were inoculated(5×10⁴/㎖, 20㎖) at barley, unpolished rice, wheat bran and rice bran and incubated for 14 days at 25℃. Wheat bran showed highest conidia production of M. anisopliae FT83 and P. funosoroseus FG340 and barley was suitable for M. anisopliae FG344.