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태아의 간과 흉선 조직 그리고 조혈모 세포를 이식한 Rag2<SUP>-/-</SUP>γc<SUP>-/-</SUP> Mice에 사람의 면역 세포 형성
강미진(Mijin Kang),주성연(Sung-Yeon Joo),최봉금(Bong-Kum Choi),정다연(Da-Yeon Jung),최호인(Ho-In Choi),박재범(Jae Berm Park),최규성(Gyuseong Choi),권준혁(Choon Hyuck Kwon),김성주(Sung-Joo Kim),조재원(Jae-Won Joh) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.1
Purpose: Many researchers have tried to develop animal models that mimic the human immune system, e.g. a humanized mouse model, to improve the engraftment of hematopoietic stem cells and develop human immune cells in an animal model. This study evaluated the feasibility of the cultured human umbilical cord blood (hUCB)-derived CD34? cells for cell expansion, in Rag2<SUP>-/-</SUP>γc<SUP>-/-</SUP> mice, and establish co-transplantation with human fetal thymus/liver tissue (Thy/Liv) under the kidney capsule. Methods: Co-transplantation of hUCB-derived CD34? cells with Thy/Liv was performed. The hUCB-derived CD34? cells were prepared by freshly thawing (G1) and culturing for 7 days with two types of cytokine combinations (G2, G3). The CD45? cell populations were measured at 6, 8, 10 and 16 weeks in the peripheral blood. The splenocytes were cultured with mitogenic stimuli (PHA -L or IL-2) at 20 weeks posttransplantation, and the proliferation of human immune cells was evaluated. Results: There were no significant differences in the human CD45? cell populations at 6, 8, 10 and 16 weeks post-transplantation between the groups. In the cultured splenocytes at 20 weeks post-transplant with PHA-L or IL-2, there was remarkable expansion of CD3? cells in the three groups. Although no CD19? cells were detected in the spleen, human Ig G was detected in the sera of these mice. Conclusion: The cultured and expanded hUCB-derived cells with cytokine combinations might be a feasible cell source in humanized mouse modeling. In addition, human immune cells can be reconstituted from the co-transplantation of Thy/Liv and cultured hUCB-derived CD34? cells.
Embedded DRAM-Based Memory Customization for Low-Cost FFT Processor Design
Kang, Gyuseong,Choi, Woong,Park, Jongsun IEEE 2017 IEEE transactions on very large scale integration Vol.25 No.12
<P>In this paper, we present embedded dynamic random access memory (eDRAM)-based memory customization techniques for low-cost fast Fourier transform (FFT) processor design. The main idea is based on the observation that the FFT processor has regular and predictable memory access patterns, and it can be efficiently exploited for memory customization using eDRAM. The memory customization approaches are applied to both of the pipelined and memory-based FFT architectures. In the pipelined architecture, the read wordline (RWL) coupling write assist and data packing schemes are employed to reduce the redundant RWL and wordline driving, respectively, in column-interleaved memory arrays. The memory address decoder is also simplified with thermometer code by exploiting the sequential access patterns. For the memory-based architecture, the modified cached-memory structure is employed in addition to the techniques used in the pipelined FFT architecture. The hardware implementation results of 2k-point FFT with a 0.11- <TEX>$\mu {\mathrm{ m}}$</TEX> CMOS technology show that the proposed eDRAM-based pipelined and cached-memory FFTs achieve 26.8% and 33.2% power savings over the static RAM-based FFT design, respectively.</P>
Han,Moon-Hee,Hwang,Won-Tae,Choi,Yong-Ho,Cho,Gyuseong 대한방사선 방어학회 1999 방사선방어학회지 Vol.24 No.2
가축의 사료로서 오염 농작물의 이용에 대한 최적기간 결정 방법론을 비용-편익 분석법에 근거하여 모델링하였다. 많은 농작물의 왕성한 성장시기인 8월 15일을 방사성물질의 침적시점 (사고시점)으로 가정하여 잡식성 가축인 돼지에 대해 적용한 결과를 논의하였다. 또한 사료로서 오염 농작물의 이용에 대한 상대적 비용 효과를 고찰하기 위해 오염 농작물을 바로 폐기시켰을 경우와 순이득을 비교·논의하였다. 침적후 농작물내 방사성물질의 농도는 동적섭식경로모델 DYNACON으로 부터 예측되었다. 대응행위에 의한 순이득은 피폭선량의 금전가와 수행에 소요되는 금전적 비용에 의해 정량적으로 평가하였다. 오염 농작물을 사료로 이용함에 대한 순이득은 핵종, 농작물의 공급분율, 공급기간 등에 따라 다양하게 나타났다. 사료로서 오염 농작물의 이용은 Cs 침적에 비해 Sr 또는 I 침적의 경우에 비용측면에서 보다 효과적이었다. A methodology for determining the optimal durations of the use of contaminated crops as feedstuffs of cattle was designed based on the cost-benefit analysis method. The results of applocation for pigs, an omnivorous cattle, were discussed for the hypothetical depostion of radionuclides on August 15 when a number of crops are fully developed in Korean agricultural conditions. For investigating the relative cost-effectiveness of the use of contaminated crops as feedstuffs, the net benefit was compared with the case of the direct disposal of contaminated crops. The time-dependent radionuclide concentration in crops after the deposition was predicted using a dynamic food chain model DYNACON. The net benefit from the actions was quantitatively evaluated in terms of cost equivalent of doses and monetary costs of implementing the action. It depended on a number of factors such as radionuclides, variety of crops supplied as feedstuffs and duration of the actions. The use of contaminated crops as feedstuffs was more cost effective for Sr or I deposition than for s deposition.
Kilyoung Ko,Wonku Kim,Hyunwoong Choi,Gyuseong Cho Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7
Methodology for suppressing or recovering the distorted spectra, which may occur due to mutual non-uniformity and nonlinear response when a multi-detector is simultaneously operated for gamma spectroscopy, is presented with respect to its applicability to stabilization of spectra having the non-identical feature using modified full spectrum reallocation method. The modified full-spectrum reallocation method is extended to provide multiple coefficients that describe the gain drift for multi-division of the spectrum and they were incorporated into an optimization process utilizing a random sampling algorithm. Significant performance improvements were observed with the use of multiple coefficients for solving partial peak dislocation. In this study, our achievements to confirm the stabilization of spectrum having differences in moments and modify the full spectrum reallocation method provide the feasibility of the method and ways to minimize the implication of the non-linear responses normally associated with inherent characteristics of the detector system. We believe that this study will not only simplify the calibration process by using an identical response curve but will also contribute to simplifying data pre-processing for various studies as all spectra can be stabilized with identical channel widths and numbers.