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A Case of Hyperglycemic Hyperosmolar State Associated with Graves' Hyperthyroidism: A Case Report
Moon, Sung Won,Hahm, Jong Ryeal,Lee, Gyeong-Won,Kang, Mi Yeon,Jung, Jung Hwa,Jung, Tae Sik,Lee, Kang Wan,Jung, Kyoung Ah,Ahn, Yong Jun,Kim, Sunjoo,Kim, Me Ae,Kim, Deok Ryong,Chung, Soon Il,Park, Myoun The Korean Academy of Medical Sciences 2006 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.21 No.4
<P>Hyperglycemic hyperosmolar state (HHS) is an acute complication mostly occurring in elderly type 2 diabetes mellitus (DM). Thyrotoxicosis causes dramatic increase of glycogen degradation and/or gluconeogenesis and enhances breakdown of triglycerides. Thus, in general, it augments glucose intolerance in diabetic patients. A 23-yr-old female patient with Graves' disease and type 2 DM, complying with methimazole and insulin injection, had symptoms of nausea, polyuria and generalized weakness. Her serum glucose and osmolarity were 32.7 mM/L, and 321 mosm/kg, respectively. Thyroid function tests revealed that she had more aggravated hyperthyroid status; 0.01 mU/L TSH and 2.78 pM/L free T3 (reference range, 0.17-4.05, 0.31-0.62, respectively) than when she was discharged two weeks before (0.12 mU/L TSH and 1.41 pM/L free T3). Being diagnosed as HHS and refractory Graves' hyperthyroidism, she was treated successfully with intravenous fluids, insulin and high doses of methimazole (90 mg daily). Here, we described the case of a woman with Graves' disease and type 2 DM developing to HHS.</P>
RAMS의 실시간 기상장 예측 향상을 위한 최신 토지피복도 자료의 적용가능성 평가
원경미(Gyeong Mee Won),이화운(Hwa Woon Lee),유정아(Jeong Ah Yu),홍현수(Hyun Su Hong),황만식(Man Sik Hwang),천광수(Kwang Su Chun),최광수(Kwang Su Choi),이문순(Moon-Soon Lee) 한국대기환경학회 2008 한국대기환경학회지 Vol.24 No.1
Chemical Accident Response Information System (CARIS) which has been designed for the efficient emergency response of chemical accidents produces the real-time atmospheric fields through the Regional Atmospheric Modeling System, RAMS. The previous studies were emphasized that improving an initial input data had more effective results in developing prediction ability of atmospheric model. In a continuous effort to improve an initial input data, we replaced the land-use dataset using in the RAMS, which is a high resolution USGS digital data constructed in April, 1993, with the latest land-use data of the Korea Ministry of Environment over the South Korea and simulated atmospheric fields for developing a real-time prediction in dispersion of chemicals. The results showed that the new land-use data was written in a standard RAMS format and shown the modified surface characteristics and the landscape heterogeneity resulting from land-use change. In the results of sensitivity experiment we got the improved atmospheric fields and assured that it will give more reliable real-time atmospheric fields to all users of CARIS for the dispersion forecast in associated with hazardous chemical releases as well as general air pollutants.
홍화씨 추출물이 MC3T3-E1 조골세포의 증식과 분화에 미치는 영향
이승용 ( Sung Yong Lee ),김수관 ( Su Gwan Kim ),이슬아 ( Seul Ah Lee ),박민경 ( Min Gyeong Park ),박선영 ( Sun Young Park ),오지수 ( Ji Su Oh ),김진수 ( Jin Soo Kim ),이동설 ( Dong Seol Lee ),문소라 ( So Ra Moon ),모신엽 ( Shin Ye 조선대학교 치의학연구원 2013 Oral Biology Research (Oral Biol Res) Vol.37 No.2
Purpose: The main aim of this study was to determine the effect of Carthamus tinctorius seed extract in the proliferation and differentiation of MC3T3-E1 osteoblastic cell line. Materials and Methods: To determine the characteristic alteration of MC3T3-E1 cells by C. tinctorius, it was examined by cell culture, MTT assay, Von Kossa staining, reverse transcriptase-polymerase chain reaction and quantitative real-time polymerase chain reaction analysis in MC3T3-E1 cells. Results: The treatment of C. tinctorius did not significantly affect the cell proliferation in MC3T3-E1 cells. C. tinctorius significantly accelerated the mineralization as compared with the control culture in the differentiation of MC3T3-E1 cells. C. tinctorius significantly increased the expression of alkaline phosphatase mRNA as compared with the control in the differentiation of MC3T3-E1 cells. C. tinctorius significantly accelerated the decrease of osteonectin mRNA expression as compared with the control in a time-dependent manner in the differentiation of MC3T3-E1 cells. Carthamus tinctorius significantly increased the expression of osteocalcin mRNA as compared with the control in the differentiation of MC3T3-E1 cells. Conclusion: These results suggest that the C. tinctorius facilitate the osteoblast differentiation and mineralization in the differentiation of MC3T3-E1 osteoblastic cells, and therefore, that it may have potential properties for development and its clinical application of bone regeneration materials.