Hepatitis B Caccine

Gust, Ian Medical Publications Korea 1978 Medical Progress Vol.5 No.7

Viral Hepatitis Identified Ⅰ : What Are the Implications?

Gust, Ian Medical Publications Korea 1985 Medical Progress Vol.7 No.10

Pb - Sn 계의 불연속 반응에 관하여

이정근,W . Gust,B . Predel 대한금속재료학회 1991 대한금속재료학회 학술대회 개요집 Vol.1991 No.0

Tabbed Tissue Expanders Improve Breast Symmetry Scores in Breast Reconstruction

Khavanin, Nima,Gust, Madeleine J.,Grant, David W.,Nguyen, Khang T.,Kim, John Y.S. Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.1

Background Achieving symmetry is a key goal in breast reconstruction. Anatomically shaped tabbed expanders are a new tool in the armamentarium of the breast reconstruction surgeon. Suture tabs allow for full control over the expander position and thus inframammary fold position, and, in theory, tabbed expanders mitigate many factors responsible for poor symmetry. The impact of a tabbed expander on breast symmetry, however, has not been formally reported. This study aims to evaluate breast symmetry following expander-implant reconstruction using tabbed and non-tabbed tissue expanders. Methods A chart review was performed of 188 consecutive expander-implant reconstructions that met the inclusion criteria of adequate follow-up data and postoperative photographs. Demographic, oncologic, postoperative complication, and photographic data was obtained for each patient. The photographic data was scored using a 4-point scale assessing breast symmetry by three blinded, independent reviewers. Results Of the 188 patients, 74 underwent reconstruction with tabbed expanders and 114 with non-tabbed expanders. The tabbed cohort had significantly higher symmetry scores than the non-tabbed cohort ($2.82/4{\pm}0.86$ vs. $2.55/4{\pm}0.92$, P=0.034). Conclusions The use of tabbed tissue expanders improves breast symmetry in tissue expander-implant-based breast reconstruction. Fixation of the expander to the chest wall allows for more precise control over its location and counteracts the day-to-day translational forces that may influence the shape and location of the expander pocket, mitigating many factors responsible for breast asymmetry.

Nicotine vs Placebo Gum in General Medical Practice

Hughes, John R.,Gust, Steven W.,Keenan, Robert M.,Fenwick, James W.,Healey, Margaret L. MediMedia Korea 1989 JAMA-Korea Vol.4 No.6

Tabbed Tissue Expanders Improve Breast Symmetry Scores in Breast Reconstruction

Nima Khavanin,Madeleine J Gust,David W Grant,Khang T Nguyen,John YS Kim 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.1

Background: Achieving symmetry is a key goal in breast reconstruction. Anatomically shaped tabbed expanders are a new tool in the armamentarium of the breast reconstruction surgeon. Suture tabs allow for full control over the expander position and thus inframammary fold position, and, in theory, tabbed expanders mitigate many factors responsible for poor symmetry. The impact of a tabbed expander on breast symmetry, however, has not been formally reported. This study aims to evaluate breast symmetry following expander-implant reconstruction usingtabbed and non-tabbed tissue expanders. Methods: A chart review was performed of 188 consecutive expander-implant reconstructionsthat met the inclusion criteria of adequate follow-up data and postoperative photographs. Demographic, oncologic, postoperative complication, and photographic data was obtained for each patient. The photographic data was scored using a 4-point scale assessing breast symmetry by three blinded, independent reviewers. Results: Of the 188 patients, 74 underwent reconstruction with tabbed expanders and 114 with non-tabbed expanders. The tabbed cohort had significantly higher symmetry scores thanthe non-tabbed cohort (2.82/4±0.86 vs. 2.55/4±0.92, P=0.034). Conclusions: The use of tabbed tissue expanders improves breast symmetry in tissue expander−implant−based breast reconstruction. Fixation of the expander to the chest wall allows for more precise control over its location and counteracts the day-to-day translational forces that may influence the shape and location of the expander pocket, mitigating many factors responsible for breast asymmetry.

Pyogenic Vertebral Column Osteomyelitis in Adults: Analysis of Risk Factors for 30-Day and 1-Year Mortality in a Single Center Cohort Study

Jeevan Vettivel,Cole Bortz,Peter Gust Passias,Joseph Frederick Baker 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.4

Study Design: Retrospective cohort study. Purpose: To describe our experience in the management and outcomes of vertebral column osteomyelitis (VCO), particularly focusing on the risk factors of early and late mortality. Overview of Literature: Previous reports suggest a global increase in spinal column infections highlighting significant morbidity and mortality. To date, there have been no reports from our local population, and no previous report has assessed the potential relationship of frailty with mortality in a cohort of patients with VCO. Methods: We reviewed 76 consecutive patients with VCO between 2009 and 2016 in Waikato Hospital, New Zealand. Demographic, clinical, microbiological, and treatment data were collected. Comorbidities were noted to calculate the modified Frailty Index (mFI). Mortality at 30 days and 1 year was recorded. Univariate and multivariate analyses were used to identify the predictors of mortality. Results: The mean age of patients was 64.1 years, with 77.6% being male. Most patients presented with axial back pain (71.1%), with the lumbar spine most commonly affected (46%). A mean of 2.1 vertebral bodies was involved. Methicillin-sensitive Staphylococcus aureus was the most common organism of infection (35.5%), and 15.8% of patients exhibited polymicrobial infection. Twenty patients (26.3%) underwent surgical intervention, which was more likely in patients with concomitant spinal epidural abscess (odds ratio [OR], 4.88) or spondylodiscitis (OR, 3.81). Mortality rate was 5.2% at 30 days and 22.3% at 1 year. The presence of frailty (OR, 13.62) and chronic renal failure (OR, 13.40) elevated the 30-day mortality risk only in univariate analysis. An increase in age (OR, 1.07) and the number of vertebral levels (OR, 2.30) elevated the 1-year mortality risk in both univariate and multivariate analyses. Conclusions: Although the mFI correlated with 30-day mortality in univariate analysis, it was not a significant predictor in multivariate analysis. An increase in age and the number of levels involved elevated the 1-year mortality risk.

Molecular catalysts for artificial photosynthesis: general discussion

Wang, M.,Artero, V.,Hammarstrom, L.,Martinez, J.,Karlsson, J.,Gust, D.,Summers, P.,Machan, C.,Brueggeller, P.,Windle, C. Royal Society of Chemistry 2017 Faraday discussions Vol.198 No.-

Cellular Adaptation to VEGF-Targeted Antiangiogenic Therapy Induces Evasive Resistance by Overproduction of Alternative Endothelial Cell Growth Factors in Renal Cell Carcinoma ¹ ²

Han, Kyung Seok,Raven, Peter A.,Frees, Sebastian,Gust, Kilian,Fazli, Ladan,Ettinger, Susan,Hong, Sung Joon,Kollmannsberger, Cristian,Gleave, Martin E.,So, Alan I. Neoplasia Press 2015 Neoplasia Vol.17 No.11

<P>Vascular endothelial growth factor (VEGF)–targeted antiangiogenic therapy significantly inhibits the growth of clear cell renal cell carcinoma (RCC). Eventually, therapy resistance develops in even the most responsive cases, but the mechanisms of resistance remain unclear. Herein, we developed two tumor models derived from an RCC cell line by conditioning the parental cells to two different stresses caused by VEGF-targeted therapy (sunitinib exposure and hypoxia) to investigate the mechanism of resistance to such therapy in RCC. Sunitinib-conditioned Caki-1 cells <I>in vitro</I> did not show resistance to sunitinib compared with parental cells, but when tested <I>in vivo</I>, these cells appeared to be highly resistant to sunitinib treatment. Hypoxia-conditioned Caki-1 cells are more resistant to hypoxia and have increased vascularity due to the upregulation of VEGF production; however, they did not develop sunitinib resistance either <I>in vitro</I> or <I>in vivo</I>. Human endothelial cells were more proliferative and showed increased tube formation in conditioned media from sunitinib-conditioned Caki-1 cells compared with parental cells. Gene expression profiling using RNA microarrays revealed that several genes related to tissue development and remodeling, including the development and migration of endothelial cells, were upregulated in sunitinib-conditioned Caki-1 cells compared with parental and hypoxia-conditioned cells. These findings suggest that evasive resistance to VEGF-targeted therapy is acquired by activation of VEGF-independent angiogenesis pathways induced through interactions with VEGF-targeted drugs, but not by hypoxia. These results emphasize that increased inhibition of tumor angiogenesis is required to delay the development of resistance to antiangiogenic therapy and maintain the therapeutic response in RCC.</P>

Properties and Prospects of ZnSe-Based Quantum Dot Microcavity VCSEL Structures

K. Sebald,H. Lohmeyer,J. Kalden,T. Meeser,J. Gutowski,C. Kruse,A. Gust,D. Hommel,J. Wiersig,N. Baer,F. Jahnke 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.1

The emission properties of ZnSe-based monolithic microcavities with either quantum wells or quantum dots embedded are studied. These pillar structured samples reveal three-dimensional conned optical modes with high-quality factors and small mode volumes conrmed by theoretical calculations. We observed a strong enhancement of the emission intensity for quantum dots being in the spectral resonance with the cavity modes. The Purcell eect was probed by using timeresolved measurements. A pronounced enhancement of the spontaneous emission rate of quantum dots coupled to the discrete optical modes of the cavities demonstrates the occurrence of cavity quantum electrodynamics eects. The observed enhancement depends systematically on the pillar diameter and, thus, on the Purcell factor of the individual pillars. The emission properties of ZnSe-based monolithic microcavities with either quantum wells or quantum dots embedded are studied. These pillar structured samples reveal three-dimensional conned optical modes with high-quality factors and small mode volumes conrmed by theoretical calculations. We observed a strong enhancement of the emission intensity for quantum dots being in the spectral resonance with the cavity modes. The Purcell eect was probed by using timeresolved measurements. A pronounced enhancement of the spontaneous emission rate of quantum dots coupled to the discrete optical modes of the cavities demonstrates the occurrence of cavity quantum electrodynamics eects. The observed enhancement depends systematically on the pillar diameter and, thus, on the Purcell factor of the individual pillars.