http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Poly-crystalline Silicon Thin Film Transistor
Amit Sehgal,Tina Mangla,Mridula Gupta,R. S. Gupta 대한전자공학회 2007 Journal of semiconductor technology and science Vol.7 No.4
A two?dimensional treatment of the potential distribution under the depletion approximation is presented for poly?crystalline silicon thin film transistors. Green’s function approach is adopted to solve the two?dimensional Poisson’s equation. The solution for the potential distribution is derived using Neumann’s boundary condition at the silicon?silicon di?oxide interface. The developed model gives insight into device behavior due to the effects of traps and grain?boundaries. Also short?channel effects and drain induced barrier lowering effects are incorporated in the model. The potential distribution and electric field variation with various device parameters is shown. An analysis of threshold voltage is also presented. The results obtained show good agreement with simulated results and numerical modeling based on the finite difference method, thus demonstrating the validity of our model.
Oxidative Stress and Antioxidants in Disease and Cancer: A Review
Gupta, Rakesh Kumar,Patel, Amit Kumar,Shah, Niranjan,Choudhary, Arun Kumar,Jha, Uday Kant,Yadav, Uday Chandra,Gupta, Pavan Kumar,Pakuwal, Uttam Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Reactive oxygen species (ROS), highly reactive molecules, are produced by living organisms as a result of normal cellular metabolism and environmental factors, and can damage nucleic acids and proteins, thereby altering their functions. The human body has several mechanisms to counteract oxidative stress by producing antioxidants. A shift in the balance between oxidants and antioxidants in favor of oxidants is termed as "oxidative stress". Paradoxically, there is a large body of research demonstrating the general effect of oxidative stress on signaling pathways, less is known about the initial and direct regulation of signaling molecules by ROS, or what we term the "oxidative interface." This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases and PI3 kinase), ROS homeostasis, and antioxidant gene regulation (Ref-1 and Nrf-2). This review also deals with classification as well as mechanisms of formation of free radicals, examining their beneficial and deleterious effects on cellular activities and focusing on the potential role of antioxidants in preventing and repairing damage caused by oxidative stress. A discussion of the role of phytochemical antioxidants in oxidative stress, disease and the epigenome is included.
Predictive Breast Cancer Statistical Modelling for Early Diagnosis
Amit Kumar Gupta,Ankit Verma,Vipin Kumar,Nikhil Kumar,Dowon Kim,Young-Jin Jung,Mangal Sain 한국자기학회 2023 Journal of Magnetics Vol.28 No.4
Breast cancer is a significant global health concern, stressing the urgent need for early detection. Early diagnosis improves access to varied treatments and significantly enhances patient outcomes. This study explores breast cancer detection over two days, aiming to create a precise and efficient machine learning model. The research uses a diverse dataset, combining clinical, genetic, and imaging data, including magnetic resonance imaging (MRI), X-ray, and electromagnetic data. Rigorous data preprocessing, including variable normalization and feature identification, enhances dataset quality. Predictive models use statistical techniques like logistic regression, decision trees, and random forest. Key metrics, such as accuracy, precision, recall, and area under the curve (AUC), assess model efficacy. Results reveal high accuracy and AUC scores, indicating potential for precise breast cancer detection. The study enhances our understanding of breast cancer dynamics, showcasing the effectiveness of machine learning for accurate and efficient early diagnosis. The research underscores diverse datasets and careful statistical modeling as crucial for predictive breast cancer capabilities.
Sehgal, Amit,Mangla, Tina,Gupta, Mridula,Gupta, R.S. The Institute of Electronics and Information Engin 2007 Journal of semiconductor technology and science Vol.7 No.4
A two-dimensional treatment of the potential distribution under the depletion approximation is presented for poly-crystalline silicon thin film transistors. Green's function approach is adopted to solve the two-dimensional Poisson's equation. The solution for the potential distribution is derived using Neumann's boundary condition at the silicon-silicon di-oxide interface. The developed model gives insight into device behavior due to the effects of traps and grain-boundaries. Also short-channel effects and drain induced barrier lowering effects are incorporated in the model. The potential distribution and electric field variation with various device parameters is shown. An analysis of threshold voltage is also presented. The results obtained show good agreement with simulated results and numerical modeling based on the finite difference method, thus demonstrating the validity of our model.
Current updates in acute traumatic aortic injury: radiologic diagnosis and management
Shivani Gupta,Atin Kumar,Tejinder Kaur,Shivanand Gamanagatti,Abhinav Kumar,Amit Gupta,Subodh Kumar 대한응급의학회 2022 Clinical and Experimental Emergency Medicine Vol.9 No.2
Acute traumatic aortic injuries, which have substantial lethal outcomes at the time of admission, are fatal in 80% to 90% of cases. These injuries are relatively rare and have nonspecific clinical presentations. Radiologists and emergency physicians need to identify the radiological signs of acute traumatic aortic injury and differentiate them from common imaging errors to ensure accurate diagnosis and determine appropriate management protocols. In combination with image-guided interventions, advances in cross-sectional imaging have enabled nonsurgical management of acute traumatic aortic injuries. Timely and precise diagnoses of these injuries following prompt treatment are essential as up to 90% of patients presenting at the hospital can undergo early repair.
Gupta, Rakesh Kumar,Patel, Amit Kumar,Kumari, Rajni,Chugh, Seema,Shrivastav, Chitrangada,Mehra, Siddharth,Sharma, Ajay Narayan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective of this study was to determine changes in the levels of malondialdehyde (MDA), nitric oxide (NO), total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in serum samples of breast cancer patients (n=30) and healthy subjects (n=100). MDA and NO levels were found to be increased in breast cancer patients compared to the healthy subject group (p<0.05). Total cholesterol and triglycerides were elevated; and HDL-cholesterol level was found to be decreased in the cancer patients as compared to the healthy subjects (p<0.05). Compared to the healthy group, both serum TAC levels (p<0.001) and activity of SOD and GSH-Px (p=0.05) were found to be decreased in the breast cancer patients as compared to the healthy controls. Considering the data presented in this study, we suggest that free radicals induce lipid eroxidation and peroxidation of unsaturated fatty acid with decreased activity of enzymatic antioxidants in breast cancer.
Gupta, Arushi,Bhardwaj, Sanjeev K.,Sharma, Amit L.,Kim, Ki-Hyun,Deep, Akash Elsevier 2019 Environmental research Vol.171 No.-
<P><B>Abstract</B></P> <P>Because of numerous merits (e.g., the possibility of their synthesis in 1-D, 2-D, and 3-D forms, large surface-to-volume ratio, and flexible framework functionality), metal-organic frameworks (MOFs) are envisaged as excellent media for the development of biosensors for diverse analytes present in environmental media. The present research work, for the first time, reports the development of a Cu-MOF based electrochemical biosensor for highly sensitive detection of <I>E. coli</I> bacteria. In order to realize an MOF-based electrochemically active platform, Cu<SUB>3</SUB>(BTC)<SUB>2</SUB> (BTC = 1,3,5-benzenetricarboxylic acid) was mixed with polyaniline (PANI). The spectroscopic/morphological characterizations of the resulting composite were established with the aid of FT-IR, UV–visible spectroscopy, X-ray diffraction, electron microscopy, and surface area analysis. The thin films of Cu<SUB>3</SUB>(BTC)<SUB>2</SUB>-PANI, on an indium-tin oxide (ITO) substrate, were bio-interfaced with anti-<I>E. coli</I> antibodies for use as a novel biosensing electrode. Based on the electrochemical impedance spectroscopy (EIS) technique of signal measurement, the above sensor exhibited high sensitivity to detect very low concentrations of <I>E. coli</I> (2cfu/mL) in a short response time (~2 min) and was also selective in the presence of other non-specific bacteria. As a novel highlight of the research, this new MOF/PANI based detection platform for <I>E. coli</I> has shown improved performance than many of the previously reported electrochemical biosensors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cu<SUB>3</SUB>(BTC)<SUB>2</SUB>-PANI based electrochemical biosensor developed for <I>E. coli</I> bacteria. </LI> <LI> EIS based quantification offers highly sensitive detection with LOD of 2 cfu/mL. </LI> <LI> Detection is highly specific even in presence of other non-specific bacteria. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>