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Guosong Shen,Pingya He,Yingying Mao,Peipei Li,Frank Luh,Guohui Ding,Xi Yong Liu,Yun Yen 한국유방암학회 2017 Journal of breast cancer Vol.20 No.2
Purpose: Uridine-cytidine kinase (UCK) 2 is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynthesis. Recent studies have shown that UCK2 is overexpressed in many types of cancer and may play a crucial role in activating antitumor prodrugs in human cancer cells. In the current study, we evaluated the potential prognostic value of UCK2 in breast cancer. Methods: We searched public databases to explore associations between UCK2 gene expression and clinical parameters in patients with breast cancer. Gene set enrichment analysis (GSEA) was performed to identify biological pathways associated with UCK2 gene expression levels. Survival analyses were performed using 10 independent large-scale breast cancer microarray datasets. Results: We found that UCK2 mRNA expression was elevated in breast cancer tissue compared with adjacent nontumorous tissue or breast tissue from healthy controls. High UCK2 levels were correlated with estrogen receptor negativity (p<0.001), advanced tumor grade (p<0.001), and poor tumor differentiation (p<0.001). GSEA revealed that UCK2-high breast cancers were enriched for gene sets associated with metastasis, progenitor-like phenotypes, and poor prognosis. Multivariable Cox proportional hazards regression analyses of microarray datasets verified that high UCK2 gene expression was associated with poor overall survival in a dose-response manner. The prognostic power of UCK2 was superior to that of TNM staging and comparable to that of multiple gene signatures. Conclusion: These findings suggest that UCK2 may be a promising prognostic biomarker for patients with breast cancer.
Yang Liu,Guosong Chen,Yuerong Gao,Kefeng Fang,Qing Zhang,Qingqin Cao,Ling Qin,Yu Xing,Shuchai Su 한국원예학회 2021 원예과학기술지 Vol.39 No.4
Chinese chestnut (Castanea mollissima) is a woody plant species with important economic and ecological value and is widely cultivated for nut production. Due to its unique flowering structure, the identification of genes related to flower development is extremely important in Chinese chestnut, and MADS-box genes are directly involved in floral organ morphogenesis. In this study, we report a MADS-box gene family in Chinese chestnut. According to their gene structure and phylogenetic trees, 53 CmMADS proteins were identified and clustered into five groups in Chinese chestnut. The MIKC<SUP>C</SUP> group was further divided into 12 subgroups, and the BS subgroup was not found in Chinese chestnut. The classification and motif composition of Chinese chestnut MADS proteins were also analyzed. Additionally, we evaluated the expression of all the MADS-box genes in floral organs by quantitative real-time PCR. Overall, most of the type II genes had higher expression levels in the floral organs compared with leaves and cotyledons. These results provide valuable information for future studies of the regulation of MADS-box genes in Chinese chestnut during flower development.
Wei Jiang,Guosong Ni,Pingping Zuo,Shijie Qu,Yunmei Li,Hongxian Niu,Wenzhong Shen 한국탄소학회 2019 Carbon Letters Vol.29 No.5
Isotropic pitch-based carbon fiber was successfully prepared from tetrahydrofuran-soluble fraction of coal tar pitch cocarbonization with petrolatum by air-blowing. The effects of reaction temperature and time, amount of petrolatum added on the composition and spinning properties of resultant pitches were investigated. It indicated that petrolatum could effectively improve the softening point, aromaticity, hydrogen content and molecular weight of the resultant pitches by promoting cross-linking and dehydrogenation polymerization reactions at low air-blowing temperature. Moreover, more aliphatic and naphthenic structures had been introduced into resultant pitches as addition of petrolatum and also inhibited the generation of quinoline-insoluble particles. The obtained green fibers were facile to be stabilized and carbonized and the resultant carbon fibers showed fully isotropic and finer, uniform diameter with smooth surface and higher tensile strength of up to 0.92 GPa. It provided a facile chemical modification method for isotropic pitch-based carbon fiber production.
Jiang, Heng Bo,Wu, Guosong,Lee, Sang-Bae,Kim, Kwang-Mahn Elsevier 2017 Surface & coatings technology Vol.313 No.-
<P><B>Abstract</B></P> <P>Magnesium (Mg) and its alloys as biodegradable metallic materials have attracted fundamental research in the field of orthopedics and cardiovascular materials. However, magnesium implants exhibit poor corrosion resistance, especially in the physiological environment, which limits medical applications. To improve the corrosion resistance of the Mg, anodization was applied to an ultra-high concentration of fluoride electrolyte. Then, surface morphology, coating thickness and composition were determined, and the corrosion behavior of anodized Mg alloys was evaluated. The results of coating by anodization showed that a porosity structure with a pore size of 600–900nm and thickness of 1–14μm is generated on the Mg alloy substrate, and this coating component is magnesium fluoride. In electrochemical corrosion tests and immersion corrosion tests, the anodized Mg alloy was tested, and the anodized Mg alloy shows significantly improved corrosion resistance compared with untreated Mg alloy in simulated body fluid (SBF).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A porous MgF<SUB>2</SUB> coating is created on Mg alloy by anodization in molten fluoride salt. </LI> <LI> The anodizing time is <30s. </LI> <LI> Corrosion resistance of the anodized Mg alloy is obviously improved. </LI> </UL> </P>
Lihua Chen,Dongxun Li,Guosong Zhang,Wei Zhang,Lihua Zhang,Yongmei Guan,Weifeng Zhu,Hongning Liu 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Peimisine, the common ingredient of ‘‘zhebeimu’’groups and ‘‘chuanbeimu’’ groups, is responsiblefor the expectorant and cough relieving effects. The aim ofthis study was to investigate the pharmacokinetics, tissuedistribution and excretion of peimisine in male and femaleSD (Sprague-Dawley) rats by a rapid and sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry)method used carbamazepine as the internal standard afteroral administration, carbamazepine was stated as an IS. The results showed that peimisine was slowly distributed,and eliminated from rat plasma and manifested lineardynamics in a dose range of 0.26–6.5 mg/kg. Tested byANOVA, there were gender differences in the pharmacokineticparameters of AUC0-t, AUC0-? among a singledose of 0.26, 1.3, 6.5 mg/kg (P\0.05). Drug blood andtissue levels in male rats were significantly higher than thefemale counterparts after oral administration, while boththe males and the females showed high drug levels inspleen, kidney, lung, liver and heart. On the other hand, thepeimisine levels that can be reached in uterus, ovary, testisand brain is low. The excretion study showed that littleadministered peimisine (\0.7 %) was recovered in themale and female bile. Approximately 13.46 and 15.05 %were recovered in female urine and feces, while 43.07 and7.49 % were recovered in male urine and feces, respectively,which indicated that the major elimination route ofmale rats was urine excretion. In addition, there was significantdifferences in total cumulative excretive ratio ofpeimisine in feces (P\0.05) and no significant differencesin the urine (P[0.05) at a dose of 1.3 mg/kg.
Jiang Wei,Ni Guosong,Zuo Pingping,Qu Shijie,Li Yunmei,Niu Hongxian,Shen Wenzhong 한국탄소학회 2019 Carbon Letters Vol.29 No.5
Isotropic pitch-based carbon fiber was successfully prepared from tetrahydrofuran-soluble fraction of coal tar pitch co-carbonization with petrolatum by air-blowing. The effects of reaction temperature and time, amount of petrolatum added on the composition and spinning properties of resultant pitches were investigated. It indicated that petrolatum could effectively improve the softening point, aromaticity, hydrogen content and molecular weight of the resultant pitches by promoting cross-linking and dehydrogenation polymerization reactions at low air-blowing temperature. Moreover, more aliphatic and naphthenic structures had been introduced into resultant pitches as addition of petrolatum and also inhibited the generation of quinoline-insoluble particles. The obtained green fibers were facile to be stabilized and carbonized and the resultant carbon fibers showed fully isotropic and finer, uniform diameter with smooth surface and higher tensile strength of up to 0.92 GPa. It provided a facile chemical modification method for isotropic pitch-based carbon fiber production.
Min Jiang,Changling Zhao,Mingfu Zhao,Yongzhong Li,Guosong Wen 한국식물학회 2020 Journal of Plant Biology Vol.63 No.2
Calcium signals play critical functions in regulating diverse arrays of plant growth and development and mediating a variety of biotic and abiotic stress responses as a second messenger. Calcineurin B-like (CBL) proteins were involved with plantspecifc Ca2+signaling as calcium sensors. In this work, we retrieved 152 CBL gene members from 15 diferent grass species, surveyed their phylogenetic relationships and sequence features and also performed expression patterns and functional analyses of rice CBLs. Phylogenetic analysis indicated that grass CBLs fall into four diferent groups (Group A–D). Sequence analysis showed that CBL proteins harboring four conserved calcium-binding EF-hand have key amino acid residues Asp and Glu which had relatively high proportion in the average abundance. Molecular evolutionary analyses revealed that group A, B and C CBLs in their evolution process sufered the purifying selection, while group D CBLs were subjected to positive selection. Moreover, expression analyses showed signifcant divergent expression patterns of OsCBLs in various organs and under diferent hormones and abiotic stresses. Furthermore, tolerance analysis revealed that OsCBL3 and OsCBL8 overexpression transgenic rice seedlings improved salt tolerance and OsCBL5, OsCBL6 and OsCBL7 positively regulated drought stress. In general, the domain and base sequence of the CBL gene family is highly conserved in grasses. OsCBL genes had specifc gene expression profles and function in diferent stresses.