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Lihua Chen,Dongxun Li,Guosong Zhang,Wei Zhang,Lihua Zhang,Yongmei Guan,Weifeng Zhu,Hongning Liu 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Peimisine, the common ingredient of ‘‘zhebeimu’’groups and ‘‘chuanbeimu’’ groups, is responsiblefor the expectorant and cough relieving effects. The aim ofthis study was to investigate the pharmacokinetics, tissuedistribution and excretion of peimisine in male and femaleSD (Sprague-Dawley) rats by a rapid and sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry)method used carbamazepine as the internal standard afteroral administration, carbamazepine was stated as an IS. The results showed that peimisine was slowly distributed,and eliminated from rat plasma and manifested lineardynamics in a dose range of 0.26–6.5 mg/kg. Tested byANOVA, there were gender differences in the pharmacokineticparameters of AUC0-t, AUC0-? among a singledose of 0.26, 1.3, 6.5 mg/kg (P\0.05). Drug blood andtissue levels in male rats were significantly higher than thefemale counterparts after oral administration, while boththe males and the females showed high drug levels inspleen, kidney, lung, liver and heart. On the other hand, thepeimisine levels that can be reached in uterus, ovary, testisand brain is low. The excretion study showed that littleadministered peimisine (\0.7 %) was recovered in themale and female bile. Approximately 13.46 and 15.05 %were recovered in female urine and feces, while 43.07 and7.49 % were recovered in male urine and feces, respectively,which indicated that the major elimination route ofmale rats was urine excretion. In addition, there was significantdifferences in total cumulative excretive ratio ofpeimisine in feces (P\0.05) and no significant differencesin the urine (P[0.05) at a dose of 1.3 mg/kg.
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Yang Liu,Guosong Chen,Yuerong Gao,Kefeng Fang,Qing Zhang,Qingqin Cao,Ling Qin,Yu Xing,Shuchai Su 한국원예학회 2021 원예과학기술지 Vol.39 No.4
Chinese chestnut (Castanea mollissima) is a woody plant species with important economic and ecological value and is widely cultivated for nut production. Due to its unique flowering structure, the identification of genes related to flower development is extremely important in Chinese chestnut, and MADS-box genes are directly involved in floral organ morphogenesis. In this study, we report a MADS-box gene family in Chinese chestnut. According to their gene structure and phylogenetic trees, 53 CmMADS proteins were identified and clustered into five groups in Chinese chestnut. The MIKC<SUP>C</SUP> group was further divided into 12 subgroups, and the BS subgroup was not found in Chinese chestnut. The classification and motif composition of Chinese chestnut MADS proteins were also analyzed. Additionally, we evaluated the expression of all the MADS-box genes in floral organs by quantitative real-time PCR. Overall, most of the type II genes had higher expression levels in the floral organs compared with leaves and cotyledons. These results provide valuable information for future studies of the regulation of MADS-box genes in Chinese chestnut during flower development.
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