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RISS 인기검색어
- 검색키워드
- 저자 : Guoqing Xing (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs
Xing Li,Limin Liao,Guoqing Chen,Zhaoxia Wang,Han Deng 대한배뇨장애요실금학회 2017 International Neurourology Journal Vol.21 No.2
Purpose: We investigated the effects of different stimulation frequencies on the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs. Methods: Implant-driven stimulators were used to stimulate the S3 spinal nerve in 13 pigs. Cystometry was performed by infusing normal saline (NS) or acetic acid (AA). SNM (pulse width, 210 μsec) at frequencies ranging from 5 to 50 Hz was conducted at the intensity threshold at which observable perianal and/or tail movement was induced. Multiple cystometrograms were performed to determine the effects of different frequencies on the micturition reflex. Results: AA-induced bladder overactivity significantly reduced the bladder capacity (BC) to 34.4%±4.7% of the NS control level (354.4±35.9 mL) (P<0.05). During AA infusion, SNM at 5 Hz did not significantly change the BC (48.1%±6.9% of the NS control level) (P>0.05), but SNM at 15, 30, and 50 Hz significantly increased the BC to 54.5%±7.1%, 55.2%±6.5%, and 57.2%±6.1% of the NS control level (P<0.05), respectively. No significant differences were found among the results obtained using frequencies of 15, 30, and 50 Hz (P>0.05). Conclusions: This study demonstrated that 15 Hz was an appropriate frequency for SNM and that frequencies higher than 15 Hz did not lead to better surgical outcomes.
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Axial Compression Performance of Reinforced Concrete Columns after Lateral Impact Load
Haoxiang Luan,Jin Wu,Tianbao Cao,Xing Zhao,Fei Geng,Guoqing Dong 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8
Axial compression performance and bearing capacity of reinforced concrete column is crucial to concrete structure. Lateral Impact load could pose severe danger to the security and service life of reinforced concrete column. Impact dynamic response, axial compression performanceand residual bearing capacity of reinforced concrete columns after lateral impact load were investigated in this paper. Investigation results indicated that with the increase of impact energy, residual displacement and crack width on column increased, impact damage on column exacerbated. It was proved that impact resistance performance of reinforced concrete column could be enhanced by preload axial force. Residual bearing capacity of reinforced concrete column degenerated obviously after subjected to lateral impact load. And RC column would be under elastic stage when impact energy was low. According to analysis results on the correlation between residual displacement and residual bearing capacity, prediction model on residual bearing capacity of reinforced concrete column after lateral impact load was proposed.
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Evaluation of the Immunomodulatory and Anti-inflammatory Activities of Honey Bee Larva Powder
Kejuan Li,Shuang Sun,Masakatsu Kageyama,Long Xiao,Guoqing Xing,Ran Gao,Fengming You,Xi Fu,Zhenya Zhang 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.7
Honey bee larva powder (HLP) has traditionally been used as a daily supplement and tonic for health promotion with an uncertain scientific basis. In this study, B16-F10 tumor-bearing mice were established to evaluate the immunomodulatory activity of HLP. The proliferation and apoptosis assays were performed to evaluate the anti-inflammatory activity of honey bee larva extract (HLE) in RAW 264.7 macrophage. The in vivo experimental results demonstrated that the oral administration of freeze-dried HLP (4 and 6 g/kg) significantly enhanced the spleen index, the percentage of CD4+cells, and the ratio of CD4+ and CD8+ T lymphocytes (CD4+/CD8+) in the peripheral blood compared with those in the tumor control mice. The in vitro studies demonstrated the potent immunomodulatory activities of HLE through the induction of RAW 264.7 macrophage proliferation and the mitigation of doxorubicin (DOX)-induced toxicity. HLE also exhibits anti-inflammatory activity by decreasing the production of nitric oxide (NO) and the cytokine level of interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage. The present study provides important scientific evidence for the immunomodulatory and anti-inflammatory activities of HLP and HLE.
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