Methazolamide와 Acetazolamide 복용 후 유발된 천식 1예

이건화,이영목,김양기,김기업,어수택,박춘식 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

A Single-Phase Hybrid Multi-Level Converter with Less Number of Components

Ki-Mok Kim(김기목),Gun-Woo Moon(문건우) 전력전자학회 2018 전력전자학술대회 논문집 Vol.2018 No.7

Effect of Circuit Training on Aging-related Hormones in Obese Middle-aged Women

Won-Mok Son(손원목),Yi-Sub Kwak(곽이섭),Gun-Do Kim(김군도),Min-Sung Ha(하민성),Song-Young Park(박송영),Gi-Dong Sung(성기동) 한국생명과학회 2017 생명과학회지 Vol.27 No.9

노화 과정에 따라 중년 여성들은 폐경 이후 체력이 저하되기 시작하면서 체지방 증가와 제지방량의 감소로 비만으로 이어지기 쉽고, 이러한 현상은 체내 호르몬의 분비의 변화와 함께 발생된다. 본 연구는 서킷 트레이닝이 비만 중년 여성의 노화 관련 호르몬에 미치는 영향을 구명하기 위해 실시하였다. 대상자 체지방률 30% 이상인 비만 중년 여성 운동군 10명, 대조군 10명 총 20명을 실시하였다. 운동 시간은 준비운동 5분, 본 운동 20분, 정리운동 5분으로 총 30분 주 3회 실시하였으며, 운동 강도는 운동자각도를 이용하여 13~17(약간 힘들다-매우 힘들다)수준으로 실시하였고, 또한 POLAR 심박수 변화량을 측정하여 1~6주는 60~70%HRR (Heart rate reserve), 7~12주는 70~80%HRR로 설정하였다. IGF-1은 운동군이 유의하게 증가하였으며, GH는 운동군이 유의하게 증가하였고, DHEA-S는 운동군이 유의하게 증가하였다. 이상의 결과 서킷 트레이닝이 비만 중년 여성의 노화 관련 호르몬에 긍정적인 영향을 준 것으로 사료된다. Due to aging, the physical fitness of middle-aged women decreases after menopause. This results in increased body fat and reduced lean body mass, both of which can lead to obesity. This phenomenon is accompanied by changes in hormone secretion in the body. The purpose of this study was to analyze the effects of circuit training on aging-related hormones in obese middle-aged women. The subjects were 20 obese middle-aged women. The subjects were divided into two groups: a circuit training group (n=10) and nonexercise control group (n=10). Growth hormone (GH), insulin-like growth factor-1 (IGF-1), estrogen, and DHEA-S were measured before and after the circuit training program. The circuit training group performed circuit training for 12 weeks, three times per week. Exercise intensity was increased gradually from 60% to 80% of heart rate reserve every 6 weeks. In the circuit training group, at the end of the 12-week training program, the IGF-1 levels were significantly increased compared to pre-exercise levels, and they were higher than those of the control group. GH levels were also significantly increased in the circuit training group, but the differences were not statistically significant. DHEA-S was significantly increased in the circuit training group, but the difference was not statistically significant. The results showed that circuit training improved aging-related hormones levels in obese middle-aged women.

Human plasma proteome analysis by reversed sequence database search and molecular weight correlation based on a bacterial proteome analysis

Park, Gun Wook,Kwon, Kyung-Hoon,Kim, Jin Young,Lee, Jeong Hwa,Yun, Sung-Ho,Kim, Seung Il,Park, Young Mok,Cho, Sang Yun,Paik, Young-Ki,Yoo, Jong Shin WILEY-VCH Verlag 2006 Proteomics Vol.6 No.4

<P>In shotgun proteomics, proteins can be fractionated by 1-D gel electrophoresis and digested into peptides, followed by liquid chromatography to separate the peptide mixture. Mass spectrometry generates hundreds of thousands of tandem mass spectra from these fractions, and proteins are identified by database searching. However, the search scores are usually not sufficient to distinguish the correct peptides. In this study, we propose a confident protein identification method for high-throughput analysis of human proteome. To build a filtering protocol in database search, we chose Pseudomonas putida KT2440 as a reference because this bacterial proteome contains fewer modifications and is simpler than the human proteome. First, the P. putida KT2440 proteome was filtered by reversed sequence database search and correlated by the molecular weight in 1-D-gel band positions. The characterization protocol was then applied to determine the criteria for clustering of the human plasma proteome into three different groups. This protein filtering method, based on bacterial proteome data analysis, represents a rapid way to generate higher confidence protein list of the human proteome, which includes some of heavily modified and cleaved proteins.</P>

Cascaded Single-Stage NPC Boost Multilevel Inverter for Distributed Generation Systems

Ki-Mok Kim,Moo-Hyun Park,Dong-Kwan Kim,Seung-Hyun Choi,Gun-Woo Moon 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

This paper presents a new cascaded single-stage boost multilevel inverter topology for distributed generation (DG) systems, which integrates the advantages of the ZSource network, the Neutral Point Clamped (NPC) and the cascaded H-Bridge (CHB). Most of DG systems, such as photovoltaic (PV), wind turbine and fuel cells, normally require a two-stage power converter with the buck-boost properties, which make it expensive, less efficient and difficult to control. However, the proposed inverter topology can implement voltage boost in a cost effective single-stage, solving the imbalance problem of the DC-link voltage. Also, it enables existing power systems to reach a much higher output voltage just by using the standard low-voltage switch devices and low voltage DC-sources in a reduced number of power cells. Moreover, it can enhance the reliability by allowing the shoot-through states without damaging the switch devices. The topology configuration and operating principle of this inverter are analyzed, and the inverter control schemes are proposed and simulated. Simulation and experimental results with a 1.2kW system are presented to validate the proposed topology and control method.

Integrated Proteomic Pipeline Using Multiple Search Engines for a Proteogenomic Study with a Controlled Protein False Discovery Rate

Park, Gun Wook,Hwang, Heeyoun,Kim, Kwang Hoe,Lee, Ju Yeon,Lee, Hyun Kyoung,Park, Ji Yeong,Ji, Eun Sun,Park, Sung-Kyu Robin,Yates, John R.,Kwon, Kyung-Hoon,Park, Young Mok,Lee, Hyoung-Joo,Paik, Young-K AMERICAN CHEMICAL SOCIETY 2016 Journal of Proteome Research Vol.15 No.11

<P>In the Chromosome-Centric Human Proteome Project (C-HPP), false positive identification by peptide spectrum matches (PSMs) after database searches is a major issue for proteogenomic studies using liquid-chromatography and mass-spectrometry-based large proteomic profiling. Here we developed a simple strategy for protein identification, with a controlled false discovery rate (FDR) at the protein level, using an integrated proteomic pipeline (IPP) that consists of four engrailed steps as follows. First, using three different search engines, SEQUEST, MASCOT, and MS-GF +, individual proteomic searches were performed against the neXtProt database. Second, the search results from the PSMs were combined using statistical evaluation tools including DTASelect and Percolator. Third, the peptide search scores were converted into E-scores normalized using an in-house program. Last, Proteinlnferencer was used to filter the proteins containing two or more peptides with a controlled FDR of 1.0% at the protein level. Finally, we compared the performance of the IPP to a conventional proteomic pipeline (CPP) for protein identification using a controlled FDR of <1% at the protein level. Using the IPP, a total of 5756 proteins (vs 4453 using the CPP) including 477 alternative splicing variants (vs 182 using the CPP) were identified from human hippocampal tissue. In addition, a total of 10 missing proteins (vs 7 using the CPP) were identified with two or more unique peptides, and their tryptic peptides were validated using MS/MS spectral pattern from a repository database or their corresponding synthetic peptides. This study shows that the IPP effectively improved the identification of proteins, including alternative splicing variants and missing proteins, in human hippocampal tissues for the C-HPP. All RAW files used in this study were deposited in ProteomeXchange (PXD000395).</P>

상용 소형 쑥뜸의 열역학적 특성에 대한 실험적 연구

이건휘,이건목,황유진 대한침구학회 2001 대한침구의학회지 Vol.18 No.6

Objective : Moxibustion has been proved efficacious for many diseases, but isn't widespread in the clinics due to a danger of skin burning, the smoke produced while burning a moxa combustion and so on. Therefore, another type of moxa that can be resolved these troubles is required. To improve the effect of moxibustion and develop the new thermal stimulating treatment, the performance of commercial moxibustion widely used are studied systematically and found out quantitatively. Methods : We have selected two types (small-size moxa A(sMA), small-size moxa B (sMB)) among small-size moxaes used widely in the clinic. We examined combustion time, various temperatures, temperature gradient in each period during a combustion of moxa. Results : 1. The combustion time in the preheating period appeared somewhat longer in sMA than in sMB. 2, The combustion time in the heating period appeared longer in sMA by 26% than in sMB. 3. The average temperature in the heating period was 37.6∼37.8℃ in sMA and 36.2∼36.8℃ in sMB and the maximum temperature measured at a center of contact surface in sMA was 48.6℃, higher by over 2.8℃ than that of sMB moxibustion. 4. The average ascending temperature gradient in the heating period was 0.08∼0.1℃/sec in both moxaes, and the average ascending temperature gradient of heating period in sMB appeared larger. The maximum ascending temperature gradient appeared higher in sMB, and the time reaching maximum ascending temperature gradient appeared much earlier in sMA than in sMB. 5. The combustion time in the retaining period was around 100 sec in sMA and around 275 sec in sMB, 6. The average temperature in the retaining period was 42.2∼46.0℃ in sMA and 39.3∼41.4℃ in sMB. The minimum temperature in the retaining period was over 38.80 in sMA but just 34.7℃ in sMB. 7. The average descending temperature gradient in sMA was -0.050∼0.067℃/sec and in sMB was-0.030∼0.037℃/sec. 8. The combustion time in the cooling period appeared longer over two times in sMA than in sMB, and the time which the cooling period (minimum temperature) finished at appeared later in sMB by 55 sec. 9. We classified the combustion process that the measured temperature rose over body heat(37℃) into the effective combustion period. The effective combustion time was 233.3 sec in sMA and 300.4 sec in sMB respectively, and was longer by about 29% in sMB. The average temperature and maximum temperature in the effective combustion time appeared higher in sMA. The time taken until the maximum temperature was reached was 225.1 sec in sMA and 244.5 sec in sMB, faster by about 20 sec in sMA. The maximum ascending temperature gradient during the effective combustion period appeared larger about 1.4 times in sMB, but the time when the maximum ascending temperature gradient happened was faster in sMA. Conclusion : It appears that sMB, compared with sMA, is proper if necessary to apply the long time and weak stimulus, because of the gentle stimulus during the relatively longer time. In contrast, sMA that the symmetrical combustion happened is proper if necessary to apply the short time and strong stimulus.

Carrageenan에 의한 근통유발이 백서의 하지근과 인대에 미치는 영향

이건휘(Gun Hyee Lee),이건목(Geon Mok Lee),황병천(Byung Chun Hwang),최정선(Jeong Son Choi),김양중(Yang Jung Kim),윤주영(Ju Young Yun) 한의병리학회 2005 동의생리병리학회지 Vol.19 No.5

Mass Death of Predatory Carp, Chanodichthys erythropterus, Induced by Plerocercoid Larvae of Ligula intestinalis (Cestoda: Diphyllobothriidae)

Woon-Mok Sohn,Byoung-Kuk Na,Soo Gun Jung,Koo Hwan Kim 대한기생충학열대의학회 2016 The Korean Journal of Parasitology Vol.54 No.3

Three cases of otitis media in a dog

Ho-Gun Kim,Ki-Young Yoon,Kyung-Won Seo,Ho-Jung Choi,Seong-Mok Jeong,Jong-Ki Cho,Seong-Jun Park 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

만성적인 외이염, 종양 등에 의한 이도의 폐색, 그리고 신경증상을 보이는 외이염과 중이염과의 발생관계를 충남대학교 부속동물병원에 내원한 3증례를 대상으로 조사하였다. 증례1은 10세령의 수컷 시츄견으로 지역동물병원에서 2-3년동안 외이염 치료를 받았으며, 지속적인 삼출몰과 소양감으로 내원하였다. 양측 외이도는 협착되어 있었으며, CT검사를 통해 고실내부의 염증을 확인하였다. 증례2는 8세령의 중성화한 수컷 코카스파니엘견으로 지역동물병원에서 3년간 외이염의 치료를 받았으나 농성분비물과 소양감이 지속되어 내원하였다. 귀 내시경 검사에서 우측 이도에 종괴가 관찰되었고, CT검사상에서 우측고실내에 연부조직 밀도의 물질이 차 있는 것이 확인되어 TECA와 LBO를 실시하였다. 증례3은 11세령의 수컷 실키테리어견으로 실신과 머리기울임의 증상으로 내원하였다. 귀 내시경 검사에서 양측에 갈색의 종괴로 인하여 외이도가 폐색된 것이 확인되었으며, CT검사로 양측 이도의 연부조직 밀도와 우측고실의 염증이 확인되었다. 3증례 모두 중이염을 진달할 수 있었으며, 치료로는 TECA와 LBO를 실시하였다.