http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP
Zu, Cong,Qin, Guangyuan,Yang, Chunshu,Liu, Ning,He, Anning,Zhang, Mingdi,Zheng, Xinyu Elsevier 2018 Biochemical and biophysical research communication Vol.505 No.4
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>The resistance to 5-FU often limits its clinical effectiveness on breast cancer treatment. Combination therapy thus is employed to overcome this treatment resistance. We here report a potent antitumor effect of Emodin at low dose on chemotherapy sensitivity of MCF-7 breast cancer cells.</P> <P><B>Methods</B></P> <P>Cell viability, apoptosis, glutathiones (GSH) concentration and Reactive oxygen species (ROS) activity following Emodin and 5-FU treatment was assessed. Cellular senescence following combined treatment and silence of NRARP was examined by senescence-associated β-galactosidase analysis. Western blot analysis was used to determine changes in the expression of p21, p16, p27, E2F1 and NRARP.</P> <P><B>Results</B></P> <P>Low dose Emodin potentiates 5-FU-induced apoptosis of breast cancer cells, in association with inhibition of NRARP, resulting in cellular senescence. RNA interference of NRARP induced cellular senescence in MCF-7 breast cancer cells. Furthermore, the cellular senescence induced by Emodin and 5-FU treatment could be reverted by pcDNA–NRARP.</P> <P><B>Conclusion</B></P> <P>These findings provide preclinical evidence for repurposing use of Emodin in combination with chemotherapeutic agents to treat breast cancer as an alternative salvage regimen.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The chemoresistance often limits clinical effectiveness of chemotherapy on breast cancer treatment. </LI> <LI> Emodin potentiates 5-FU-induced apoptosis of breast cancer cells. </LI> <LI> Low dose Emodin induces cellular senescence in breast cancer cells by inhibition of Nrarp. </LI> </UL> </P>
Sun, Jie,Zheng, Guangyuan,Lee, Hyun-Wook,Liu, Nian,Wang, Haotian,Yao, Hongbin,Yang, Wensheng,Cui, Yi American Chemical Society 2014 NANO LETTERS Vol.14 No.8
<P>High specific capacity battery electrode materials have attracted great research attention. Phosphorus as a low-cost abundant material has a high theoretical specific capacity of 2596 mAh/g with most of its capacity at the discharge potential range of 0.4–1.2 V, suitable as anodes. Although numerous research progress have shown other high capacity anodes such as Si, Ge, Sn, and SnO<SUB>2</SUB>, there are only a few studies on phosphorus anodes despite its high theoretical capacity. Successful applications of phosphorus anodes have been impeded by rapid capacity fading, mainly caused by large volume change (around 300%) upon lithiation and thus loss of electrical contact. Using the conducting allotrope of phosphorus, “black phosphorus” as starting materials, here we fabricated composites of black phosphorus nanoparticle-graphite by mechanochemical reaction in a high energy mechanical milling process. This process produces phosphorus–carbon bonds, which are stable during lithium insertion/extraction, maintaining excellent electrical connection between phosphorus and carbon. We demonstrated high initial discharge capacity of 2786 mAh·g<SUP>–1</SUP> at 0.2 C and an excellent cycle life of 100 cycles with 80% capacity retention. High specific discharge capacities are maintained at fast C rates (2270, 1750, 1500, and 1240 mAh·g<SUP>–1</SUP> at C/5, 1, 2, and 4.5 C, respectively).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2014/nalefd.2014.14.issue-8/nl501617j/production/images/medium/nl-2014-01617j_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl501617j'>ACS Electronic Supporting Info</A></P>
Sanwen Peng,Gang Ouyang,Xiangwei Cao,Ning Hou,Guangyuan Yang,Fei Yan,Fengxiang Xu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.6
In this work, we describe experimental water vapor forming of hollow filter rods. The morphology, microstructure and mechanical property of hollow filter rods were carefully investigated. The forming mechanism of hollow filter rods was also discussed. The results demonstrated that a well-formed product was successfully obtained under the best process parameters. The circumference means of tested samples can be mainly determined by water vapor pressure and plasticizer concentration. However, the roundness of hollow filter rods depended on cellulose tow content. The occurrence of surface fuzzing and bending deflection was largely as the result of incomplete curing effect while the emergence of intermittent formation may rely on the tow feed volume during the forming process. The acceptable hardness of hollow filter rods was up to 92.27 % in the experiments. An improvement in hardness was mainly attributive to crisscrossing three-dimensional structures formed inside the filter rod. A model consisting of the diffusion stage, crosslinking stage and solidifying stage was proposed to illustrate the formation of filter rods.