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RISS 인기검색어
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- 저자 : Gloria Huang (검색결과 2 건)
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Stage III uterine serous carcinoma: modern trends in multimodality treatment
Jessie Y. Li,Melissa R. Young,Gloria Huang,Babak Litkouhi,Alessandro Santin,Peter E. Schwartz,Shari Damast 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4
Objective: To examine outcomes in a modern treatment era for stage III uterine serouscarcinoma (USC). Methods: Fifty women were retrospectively identified as 2009 International Federation ofGynecology and Obstetrics stage III USC patients who received radiotherapy (RT) at ourinstitution between 1/2003–5/2018. The patients were divided into 2 cohorts: 20 in the earlyera (2003–2010) and 30 in the modern era (2011–2018). Patient characteristics were comparedusing χ2tests for categorical variables and t-tests for continuous variables. Recurrence freesurvival (RFS) and overall survival (OS) were analyzed with Kaplan-Meier estimates, the log rank test, and Cox proportional hazards. Results: The modern era differed from the early era in the increased use of volume-directedexternal beam RT (EBRT) as opposed to vaginal brachytherapy (VB) alone (33.3% vs 5.0%,p=0.048), minimally invasive surgery (56.7% vs. 25%, p=0.027), sentinel node sampling(26.7% vs. 0%, p=0.012), computed tomography imaging in the perioperative period (63.3%vs. 30%, p=0.044), and human epidermal growth factor receptor 2/neu testing (96.7% vs. 55%, p=0.001). Median follow-up for early and modern eras was 37.27 and 33.23 months,respectively. The early vs. modern 3-year RFS was 33% and 64% (p=0.039), respectively, whilethe 3-year OS was 55% and 90% (p=0.034). Regional nodal recurrence more common amongthe patients who received VB only (p=0.048). Conclusion: Modern era treatment was associated with improved RFS and OS in patientswith stage III USC. Regional nodal recurrences were significantly reduced in patients whoreceived EBRT
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Financial toxicity in patients with gynecologic malignancies: a cross sectional study
Burak Zeybek,Emily Webster,Natalia Pogosian,Joan Tymon-Rosario,Alan Balch,Gary Altwerger,Mitchell Clark,Gulden Menderes,Gloria Huang,Masoud Azodi,Elena S. Ratner,Peter E. Schwartz,Alessandro D. Santin 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.6
Objective: To evaluate financial toxicity and assess its risk factors among patients with gynecologic cancers. Methods: This is a cross sectional study that included 2 survey tools, as well as patient demographics, disease characteristics, and treatment regimen. Financial toxicity is measured by validated Comprehensive Score for Financial Toxicity (COST) tool. Participants were also asked to complete a 55-question-survey on attitudes and perspectives surrounding cost of care. Descriptive statistics was used to report patient demographics. Spearman's rank correlation was calculated to assess the relation between financial toxicity and patient/ disease related variables. Graphpad Prism Software Version 8.0 was used for analyses. Results: A total of 50 patients with various gynecologic malignancies were enrolled. Median COST score was 20.5 (range, 1–33). Sixty-five percent of the patients reported being in debt due to their cancer care and 4% filed bankruptcy. Correlation analysis showed that COST score was correlated with age (r=−0.3, p=0.028), malignancy type (r=0.3, p=0.039) and income (r=0.3, p=0.047). Ovarian cancer patients had significantly less financial toxicity (median COST score=23) when compared to patients with other gynecologic malignancies (median COST score=17, p=0.043). When scores were dichotomized into low (score ≥22) and high toxicity (score <22), 58% (29/50) of the patients were noted to have high financial toxicity. Enrollment to a clinical trial did not significantly alleviate financial burden. Conclusion: Financial toxicity is a significant burden even among highly insured gynecologic oncology patients. Age, malignancy type and income were correlated with high financial burden.
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