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- 저자 : Melissa R. Young (검색결과 3 건)
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Stage III uterine serous carcinoma: modern trends in multimodality treatment
Jessie Y. Li,Melissa R. Young,Gloria Huang,Babak Litkouhi,Alessandro Santin,Peter E. Schwartz,Shari Damast 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4
Objective: To examine outcomes in a modern treatment era for stage III uterine serouscarcinoma (USC). Methods: Fifty women were retrospectively identified as 2009 International Federation ofGynecology and Obstetrics stage III USC patients who received radiotherapy (RT) at ourinstitution between 1/2003–5/2018. The patients were divided into 2 cohorts: 20 in the earlyera (2003–2010) and 30 in the modern era (2011–2018). Patient characteristics were comparedusing χ2tests for categorical variables and t-tests for continuous variables. Recurrence freesurvival (RFS) and overall survival (OS) were analyzed with Kaplan-Meier estimates, the log rank test, and Cox proportional hazards. Results: The modern era differed from the early era in the increased use of volume-directedexternal beam RT (EBRT) as opposed to vaginal brachytherapy (VB) alone (33.3% vs 5.0%,p=0.048), minimally invasive surgery (56.7% vs. 25%, p=0.027), sentinel node sampling(26.7% vs. 0%, p=0.012), computed tomography imaging in the perioperative period (63.3%vs. 30%, p=0.044), and human epidermal growth factor receptor 2/neu testing (96.7% vs. 55%, p=0.001). Median follow-up for early and modern eras was 37.27 and 33.23 months,respectively. The early vs. modern 3-year RFS was 33% and 64% (p=0.039), respectively, whilethe 3-year OS was 55% and 90% (p=0.034). Regional nodal recurrence more common amongthe patients who received VB only (p=0.048). Conclusion: Modern era treatment was associated with improved RFS and OS in patientswith stage III USC. Regional nodal recurrences were significantly reduced in patients whoreceived EBRT
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REMMEN, HOLLY VAN,WILLIAMS, MELISSA D.,HEYDARI, AHMAD R.,TAKAHASHI, RYOYA,CHUNG, HAE YOUNG,YU, KYUNG P.,RICHARDSON, ARLAN 부산대학교 유전공학연구소 1996 분자생물학 연구보 Vol.12 No.-
The expression of genes for heat shock proteins in the HSP70 family and genes for antioxidant enzymes was studied in rat hepatocytes cultured in either L-15 or Williams E media on a collagen matrix for up to 48 hours. The mRNA transcripts for the heat shock proteins hsp70, hsc70, and grp78 were induced dramatically when hepatocytes were cultured in L-15, and to a lesser extent when cultured in Williams E. The increase in hsp70 and hsc70 mRNA levels in the cultured hepatocytes was correlated with an increase in the nuclear transcription of these two genes and the binding activity of the heat shock transcription factor to the heat shock element. Culturing rat hepatocyters in either L-15 or Willians E resulted in a decrease in the levels of the mRNA transcripts for catalase and glutathione peroxidase and the activities of these two enzymes. However, the expression of Cu/Zn-superoxide dismutase, i.e., the level of the mRNA transcript or the enzymatic activity, did not change appreciably when hepatocytes were cultured for up to 48 hours. The decline in catalase and glutathione peroxidase expression in the cultured hepatocytes was correlated with a decrease in the GSH/GSSG ratio and an increase in lipid peroxidation. These data show that the expression of several genes involved in cellular protection change when hepatocytes are placed in primary cultures. Therefore, one must be careful in extrapolating from primary cultures to the liver in vivo, especially when studying processes that might be affected by heat shock proteins or antioxidant enzymes.
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Jack M. Qian,John M. Stahl,Melissa R. Young,Elena Ratner,Shari Damast 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.6
Objective: To examine the outcomes (tolerability, toxicity, and recurrence) of vaginalbrachytherapy (VBT) among endometrial cancer (EC) patients treated with small cylinder size. Methods: Patients with EC who received adjuvant VBT between September 2011 andDecember 2015 were reviewed. Patients were fitted with the largest vaginal cylinder theycould comfortably accommodate, from 2.0–3.0 cm diameter. Small cylinders were defined assize 2.3 cm or less. Patient, tumor, or treatment characteristics were correlated with need forsmall cylinders. Treatment tolerability, measures of gastrointestinal (GI), genitourinary (GU),and vaginal toxicity, and rates of recurrence were analyzed. Results: Three hundred four patients were included. Small cylinders were used in 51 patients(17%). Normal body mass index (BMI; p<0.001), nulligravidity (p<0.001), and shorter vaginallength (p<0.001) were associated with small cylinder size. There was no acute or late grade 3toxicity. Rates of acute (grade 1–2) GI, GU, or vaginal symptoms were low (10%, 11%, and 19%,respectively). Small cylinder size was associated with increased likelihood of reporting acuteGI (p<0.05) but not GU or vaginal symptoms. Small cylinder size was associated with higherrisk of grade 1–2 vaginal stenosis (odds ratio [OR]=4.7; 95% confidence interval [CI]=1.5–14.7;p=0.007). There was no association between cylinder size and recurrence rate (p=0.55). Conclusion: VBT is generally very well tolerated, however, patients fitted with smallercylinders (commonly nulligravid and low BMI) may have increased side effects. Further studyto improve the dosimetry of VBT for patients requiring small cylinders may be worthwhile.
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