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김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.
대황황련해독탕의 사염화탄소 유발 간장해 보호효과 미치 급성독성
김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
ABSTRACT - This study was performed to evaluate hepatoprotective effect of daewhang-whangryunhaedok-Tang(DWT) on liver injured rats induced by CCI_4 and the acute oral toxicity of it in mice. The activities of serum transaminase(ALT/AST), alkaline phosphatase(ALP) and lactic dehydrogenase(LDH), the levels of serum total cholesterol(TC) and triglyceride(TG), change of liver enlargement, and inhibitory activities of lipid perotidation, catalase and glutathione-S-transfrease(GST) in liver microsome were determined in hepatotoxic rats induced by CCI_4. DWT was significantly reduced the serum ALT, AST, ALP, LDH. TC and TG lecels. And, the increase of lipid peroxidation, decrease of catalase and GST activities in the liver microsome of CCI_4-intoxicated rat were significantly improved by the treatment of DWT. Male and female mice were administered maximum dosages of 5.000 mg/kg b.w. of DWT. After single oral administration of DWT to mice, we observed them daily for 2 weeks.DWT did not induce any toxic signs in the mortalitie, clinical signs, body weight changes, and gross necropsy finfings of mice. Based in these results. It is concluded that DWT may have the hepatoprotective effect on CCI_4 induced hepatotoxicity in rats. Also. DWT may have no side effect and its LD_50 value may be over 5.000mg/kg b.w. in mice.
정승기,남철현,신두만,양숙희,김기열,이미경,문기내 대한보건협회 2002 대한보건연구 Vol.28 No.3
This study was conducted to examine the condition of patients with arthritis and its related factors. Data were collected from 100 people who suffered from arthritis in Seoul. Busan, Daegu, Daejun, Junjoo, and pohang from April 2, 2000 to July 31, 2000. The results of this study are summarized as follows : 1. 6L0% of the subjects were female. The incidence rate of arthritis was higher in the higher age group, lower educated group, and thinner group. In case of male, the incidence rate was higher in the groups of single, residents in big cities, and technicians. In case of female, it was higher in the groups of the married, residents in towns or villages, and housewives. 2. According to the parts of arthritis, knee joint covered 67.4% and backspine joint covered 9.0%. The incidence rate of arthritis was higher in the groups of forties, housewives, single, irreligious people, residents in towns and villages, primary school graduates, thin people, and walk exercisers. 3. The arthritis patients felt pain most when they stood up (31.5%). According to the time when they felt pain most, the time when they were active during daytime was 31.5% and nighttime was 29.8%. When they got up in the morning was 22.4%, while 10.9% felt pain all cay long. 4. they had arthralgia knees and cramp in crook of the knees (21.8%). Their knees ticked when they moved (21.1%). The had to rest hands on anyplace when they stood up (18.7%) and they could not completely unfold their knees. 5. The medical institutions which diagnosed them showed significant difference in the variables of sex, age, marital status, religion, place in residence, education level, economic status, obesity level, exercise, parts of arthritis, and posture of feeling pain. from above results, it can be concluded that it is necessary to develop appropriate medical treatment on the basis of the respondents' socio-democraphic characteristics, pain parts, period of having a pain, satisfaction level with treatment and its related factors. Therefore, related professionals and organizations must develop education program for prevention of arthritis in order to educate them.
오남호(Nam-Ho Oh),유석대(Suk-Dea Yu),고광신(Kwang-Shin Koh),조기환(Gi-Hwan Cho) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.1A
인터넷의 비약적인 성장과 더불어 WWW는 컴퓨터의 절대적인 응용으로 이용되고 있다. 기존 웹은 단순한 정보검색 및 처리에서 전자상거래와 같은 중요 데이터를 다루는 추세로 바뀌는 있다. 한편 무선 매체를 이용한 웹 접속이 일반화되는 상황에서 웹 서비스를 위한 기존의 C_S(클라이언트-서버) 모델을 이동 호스트에 그대로 적용하기에는 여러가지 문제가 따른다. 본 논문에서는 이동 호스트가 웹을 이용할 때 클라이언트와 서버 사이에 비동기적인 트랜잭션을 지원할 방법을 제안한다. 방법론은 MMS(Mobile Management Server)를 기반으로 하는 클라이언트-서버 모델과 이동호스트를 위한 웹 서비스 구조를 포함한다.
Myung-Gi Seo,Min-Jeong Jo,Nam In Hong,Min Jung Kim,Kyu Suk Shim,Eunju Shin,Jeong Jun Lee,Sang-Joon Park 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Venous insufficiency results from several factors responsible for the progression of inflammation and oxidative damage of veins. Recently, natural extracts have been proposed for the treatment of venous insufficiency, but their efficacies have not been fully elucidated. In the present study, we evaluate the combinatorial effects on anti-inflammatory and anti-vascular leakage potential of mixed compositions containing different proportions of Centella asiatica extracts (CE) and Vitis vinifera L. leaf extracts (VVE) using an inflammation model of lipopolysaccharide (LPS)-stimulated RAW264.7 cells and various vascular permeability models in mice (acetic acid-induced peritoneal vascular model, mustard oil-stimulated ear vascular model, and carrageenan-induced paw edema model). Pretreatment of CE and VVE in a 1:3 combination dose-dependently inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) through downregulation of the nuclear factor-κB (NF-κB) pathway in LPS-stimulated RAW264.7 macrophages. In vascular permeability-related mouse models, pretreatment with the CE-VVE 1:3 combination significantly reduced the permeability of peritoneal or ear veins caused by acetic acid and mustard oil, respectively. Furthermore, pretreatment of CE-VVE 1:3 combination ameliorated inflammation and edema of the hind paw caused by carrageenan injection. Thus, combination of CE and VVE showed significant anti-inflammatory qualities and anti-vascular leakage effects. These findings indicate that an optimal combination of CE and VVE may have more synergistic effect than that of CE or VVE alone as a putative agent against vascular incompetence.