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Geurts Sandra ME,Aarts Anne MWM,Verbeek André LM,Chen Tony HH,Broeders Mireille JM,Duffy Stephen W 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES: The aim of this study was to provide an overview of published mathematical estimation approaches to quantify the duration of the preclinical detectable phase (PCDP) using data from cancer screening programs. METHODS: A systematic search of PubMed and Embase was conducted for original studies presenting mathematical approaches using screening data. The studies were categorized by mathematical approach, data source, and assumptions made. Furthermore, estimates of the duration of the PCDP of breast and colorectal cancer were reported per study population. RESULTS: From 689 publications, 34 estimation methods were included. Five distinct types of mathematical estimation approaches were identified: prevalence-to-incidence ratio (n= 8), maximum likelihood estimation (n= 16), expectation-maximization algorithm (n= 1), regression of observed on expected (n= 6) and Bayesian Markov-chain Monte Carlo estimation (n= 5). Fourteen studies used data from both screened and unscreened populations, whereas 19 studies included only information from a screened population. Estimates of the duration of the PCDP varied between 2 years and 7 years for breast cancer in the Health Insurance Plan study (annual mammography and clinical breast examinations in women aged 40-64 years) and 2 years and 5 years for colorectal cancer in the Calvados study (a guaiac fecal occult blood test in men and women aged 45-74 years). CONCLUSIONS: Different types of mathematical approaches lead to different estimates of the PCDP duration. We advise researchers to use the method that matches the data available, and to use multiple methods for estimation when possible, since no method is perfect
Wind loads on T-shaped and inclined free-standing walls
Geurts, Chris,van Bentum, Carine Techno-Press 2010 Wind and Structures, An International Journal (WAS Vol.13 No.1
Wind tunnel measurements on T-shaped free-standing walls and inclined free-standing walls have been carried out. Mean net pressure coefficients have been derived and compared with previous research. It was observed that the high loads at the free ends are differently distributed than those derived from the pressure coefficients for free-standing walls in EN 1991-1-4. In addition net pressure coefficients based on extreme value analysis have been obtained. The lack of correlation of the wind induced pressures at windward and leeward side result in lower values for the net pressure coefficients when based on extreme value analysis. The results of this wind tunnel study have been included in Dutch guidelines for noise barriers.
Wind loads on T-shaped and inclined free-standing walls
Chris Geurts,Carine van Bentum 한국풍공학회 2010 Wind and Structures, An International Journal (WAS Vol.13 No.1
Wind tunnel measurements on T-shaped free-standing walls and inclined free-standing walls have been carried out. Mean net pressure coefficients have been derived and compared with previous research. It was observed that the high loads at the free ends are differently distributed than those derived from the pressure coefficients for free-standing walls in EN 1991-1-4. In addition net pressure coefficients based on extreme value analysis have been obtained. The lack of correlation of the wind induced pressures at windward and leeward side result in lower values for the net pressure coefficients when based on extreme value analysis. The results of this wind tunnel study have been included in Dutch guidelines for noise barriers.
Kasperski, Michael,Geurts, Chris Techno-Press 2005 Wind and Structures, An International Journal (WAS Vol.8 No.4
The paper describes the work of the IAWE Working Group WBG - Reliability and Code Level, one of the International Codification Working Groups set up at ICWE10 in Copenhagen. The following topics are covered: sources of uncertainties in the design wind load, appropriate design target values for the exceedance probability of the design wind load for different structural classes with different consequences of a failure, yearly exceedance probability of the design wind speed and specification of the design aerodynamic coefficient for different design purposes. The recommendations from the working group are summarized at the end of the paper.
Updates of prostate cancer staging: Prostate-specific membrane antigen
Niranjan J Sathianathen,Alastair Lamb,Rajesh Nair,Nicolas Geurts,Catherine Mitchell,Nathan L Lawrentschuk,Daniel A Moon,Declan G Murphy 대한비뇨의학회 2016 Investigative and Clinical Urology Vol.57 No.-
The ability to accurately stage prostate cancer in both the primary and secondary staging setting can have a major impact on management. Until recently radiological staging has relied on computer tomography, magnetic resonance imaging, and nuclear bone scans to evaluate the extent of disease. However, the utility of these imaging technologies has been limited by their sensitivity and specificity especially in detecting early recurrence. Functional imaging using positron-emission tomography with a radiolabeled ligand targeted to prostate-specific membrane antigen has transformed the prostate cancer imaging landscape. Initial results suggest that it is a substantial improvement over conventional imaging in the setting of recurrence following primary therapy by having a superior ability to detect disease and to do so at an earlier stage. Additionally, it appears that the benefits seen in the secondary staging setting may also exist in the primary staging setting.
Lisette Dekker,Michiel T.J. Bak,Willem A. Bemelman,Richelle J.F. Felt-Bersma,Ingrid J.M. Han-Geurts 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.2
Purpose: Standard therapy for grade III hemorrhoids is rubber band ligation (RBL) and hemorrhoidectomy. The long-term clinical and patient-reported outcomes of these treatments in a tertiary referral center for proctology were evaluated. Methods: A retrospective analysis was performed in all patients with grade III hemorrhoids who were treated between January 2013 and August 2018. Medical history, symptoms, reinterventions, complications, and patient-reported outcome measurements (PROM) were retrieved from individual electronic patient files, which were prospectively entered as standard questionnaires in our clinic. Results: Overall, 327 patients (163 males) were treated by either RBL (n=182) or hemorrhoidectomy (n=145). The median follow-up was 44 months. The severity of symptoms and patient preference led to the treatment of choice. The most commonly experienced symptoms were prolapse (83.2%) and blood loss (69.7%). Hemorrhoidectomy was effective in 95.9% of the cases as a single procedure, while a single RBL procedure was only effective in 51.6%. In the RBL group, 34.6% received a second RBL session. Complications were not significantly different, 11 (7.6%) after hemorrhoidectomy versus 6 (3.3%) after RBL. However, 4 fistulas developed after hemorrhoidectomy and none after RBL (P<0.05). The pre-procedure PROM score was higher in the hemorrhoidectomy group whereas the post-procedure PROM score did not significantly differ between the groups. Conclusion: Treatment of grade III hemorrhoids usually requires more than one session RBL whereas 1-time hemorrhoidectomy suffices. Complications were more common after hemorrhoidectomy. The patient-related outcome did not differ between procedures.