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( Francisco J. Pérez-de Los Santos ),( Luis Fernando García-ortega ),( Karina Robledo-márquez ),( Jesús Guzmán-moreno ),( Lina Riego-ruiz ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.5
After Candida albicans, Candida glabrata is one of the most common fungal species associated with candidemia in nosocomial infections. Rapid acquisition of nutrients from the host is important for the survival of pathogens which possess the metabolic flexibility to assimilate different carbon and nitrogen compounds. In Saccharomyces cerevisiae, nitrogen assimilation is controlled through a mechanism known as Nitrogen Catabolite Repression (NCR). NCR is coordinated by the action of four GATA factors; two positive regulators, Gat1 and Gln3, and two negative regulators, Gzf3 and Dal80. A mechanism in C. glabrata similar to NCR in S. cerevisiae has not been broadly studied. We previously showed that in C. glabrata, Gln3, and not Gat1, has a major role in nitrogen assimilation as opposed to what has been observed in S. cerevisiae in which both factors regulate NCR-sensitive genes. Here, we expand the knowledge about the role of Gln3 from C. glabrata through the transcriptional analysis of BG14 and gln3Δ strains. Approximately, 53.5% of the detected genes were differentially expressed (DEG). From these DEG, amino acid metabolism and ABC transporters were two of the most enriched KEGG categories in our analysis (Up-DEG and Down-DEG, respectively). Furthermore, a positive role of Gln3 in AAA assimilation was described, as was its role in the transcriptional regulation of ARO8. Finally, an unexpected negative role of Gln3 in the gene regulation of ABC transporters CDR1 and CDR2 and its associated transcriptional regulator PDR1 was found. This observation was confirmed by a decreased susceptibility of the gln3Δ strain to fluconazole.
Karla F. García-Verdugo,Andya J. Ramírez-Irigoyen,Mónica Castillo-Ortega,Dora E. Rodríguez-Félix,Jesús M. Quiroz-Castillo,Judith Tánori-Córdova,Francisco Rodríguez-Félix,Antonio Ledezma-Pérez,Teresa d 한국고분자학회 2022 Macromolecular Research Vol.30 No.6
A novel semi-interpenetrating polymer network (s-IPN) based on the entrapment of a thermosensitive polymer, the poly(vinyl methyl ether) (PVME), within a crosslinked 3D structure of poly(vinyl alcohol) (PVA) and poly(vinyl methyl etheralt- maleic acid) (COP) was synthesized by an autoclaving process. The preparation method avoids the use of toxic crosslinkers and allows the simultaneous sterilization of material. The PVA/COP/PVME hydrogel were characterized by Fourier transform infrared spectroscopy, thermal techniques, swelling kinetic measurements, scanning electron microscopy, and rheological analysis. The entrapment of PVME within the hydrated polymer framework significantly modified its transition temperature at pH 7.4 and pH 3 conditions. The swelling kinetics of the s-IPN were dependent on pH (7.4, 3 and 1), and temperature (25 and 37℃). The interpenetrated polymer chains reduced the internal pore sizes of crosslinked network without altering its elastic, solid-like behavior. The loading and in vitro release of 5-fluorouracil, a chemotherapeutic agent, from hydrogel systems were studied at different temperature and pH values. The hydrogels showed a sustained drug release up to 5 h at 37℃, in different pH media. The s-IPN exhibited a promising performance for a range of biomedical applications, in particular, for the controlled drug delivery in response to the pH and temperature conditions.
Francisco J. Ortega,Francisco J. Navarro,Moisés García-Morales,Tony McNally 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-
Polymer modified bitumens (PMBs) have largely been utilized as a construction material. However, lackof affinity between bitumen and polymer leads to phase separation, and eventually, performancedepletion. In this paper, alternative formulations of bitumen with an organically-modified montmorillonite(OMMT) Cloisite 20A1 and polymeric methylene diphenyl diisocyanate (MDI) were prepared bymelt blending. Their comprehensive rheological characterisation evidenced improved linear viscoelasticproperties when OMMT is added, revealing a noticeable structural reinforcement and thermal stability. Rheological data also showed that MDI-involved reactions control the composite end properties, beinggreatly influenced by the shear conditions applied
Inference in affine shape theory under elliptical models
Francisco J. Caro-Lopera,José A. Díaz-García,Graciela González-Farías 한국통계학회 2014 Journal of the Korean Statistical Society Vol.43 No.1
This paper studies the elliptical statistical affine shape theory under certain particular conditionson the evenness or oddness of the number of landmarks. In such a case, the relateddistributions are polynomials, and the inference is easily performed; as an example, a landmarkdata is studied, and the performance of the polynomial density versus the usual seriesdensity is compared.
Reconstruction methodology of a Francis runner blade using numerical tools
Giovanni Delgado,Sergio Galván,Francisco Dominguez-Mota,J. C. García,Esteban Valencia 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.3
In a hydraulic turbine, the search of a better energy exchange with the fluid has led to designs of runner blade of geometrical shapes so complex that they are considered as free-form surfaces. Since such blade characteristics are unable to be expressed by analytic functions, its complete and realistic geometrical reconstruction requires an excessive quantity of design parameters. This study proposes a coherent and robust full 3D blade numerical reconstruction methodology in which the geometrical definition of the blade is independent of its design parameters. A quantitative and qualitative fit evaluation shows that the blade surface reconstruction needs an important quantity of discrete data along the spanwise and streamwise direction to achieve a continuous and smooth definition. The results infer that the shape characteristics of damaged and worn blades without an original CAD model could be recovered, making this methodology attractive for industrial and optimization applications.
Bursectomy, Curettage, and Chemotherapy in Tuberculous Trochanteric Bursitis
Luis R. Ramos-Pascua,José A. Carro-Fernández,José A. Santos-Sánchez,Paula Casas Ramos,Luis J. Díez-Romero,Francisco M. Izquierdo-García 대한정형외과학회 2016 Clinics in Orthopedic Surgery Vol.8 No.1
We presented three patients with trochanteric tuberculosis and described the clinical and imaging findings of the infection. Histology revealed a necrotizing granulomatous bursitis and microbiology confirmed tuberculosis. All cases were successfully treated with bursectomy and curettage of the trochanteric lesion and antituberculous chemotherapy including isoniazid, pyrazinamide, rifampicin, and ethambutol.
Rodríguez-Gómez Irene,Sánchez-Martín Coral,García-García Francisco J.,García-Esquinas Esther,Miret Marta,Vicente-Rodriguez Germán,Gusi Narcís,Mañas Asier,Carnicero José A.,Gonzalez-Gross Marcela,Ayuso 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES: This study investigated the associations of chronic diseases with changes in lifestyle and health behaviours in older people following the coronavirus disease 2019 (COVID-19) lockdown in Spain and compared the differences in changes over time. METHODS: 1,092 participants (80.3± 5.6 years; 66.5% female) from 2 Spanish cohorts were included. Telephone-based questionnaires were conducted to evaluate lifestyle and health risk behaviours at the end of lockdown and 7 months post-lockdown. Participants were classified as having physician-diagnosed chronic diseases based on self-reported data. Cox proportional models adjusted for major confounders were used. RESULTS: Compared to those without the corresponding chronic diseases, older people with hypertension were less likely to report increased alcohol consumption (hazard ratio [HR], 0.73; 95% confidence interval [CI], 0.55 to 0.99). Pulmonary diseases were associated with lower risks of increased sedentary time (HR, 0.58; 95% CI, 0.39 to 0.86) and worsened sleep quality (HR, 0.56; 95% CI, 0.36 to 0.87), while cardiovascular diseases were associated with a lower risk of decreased sedentary time (HR, 0.58; 95% CI, 0.38 to 0.88). Depression was linked to a higher likelihood of improved diet quality (HR, 1.53; 95% CI, 1.00 to 2.36). Cancer pacients were less likely to have worsened sleep quality (HR, 0.44; 95% CI, 0.22 to 0.89) but more likely to have reduced their frequency of social contact (HR, 2.05; 95% CI, 1.05 to 3.99). CONCLUSIONS: Older people with chronic diseases showed beneficial changes in lifestyle and health risk behaviours after the COVID-19 lockdown. In particular, older people with hypertension, pulmonary disease, and cancer tended to make beneficial lifestyle and health behaviour changes. However, older people with cardiovascular disease and depression engaged in more health risk behaviours.