Could Irisin Levels be Affected by Physical Activity in Patients with Schizophrenia?

Gamze Erzin,Olga Güriz,Ali Yalçındağ,Akfer Kahıloğulları,Sibel Örsel 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.4

Objective: The aim of this study was to explore the effect of physical activity and metabolic parameters on irisin levels in patients with schizophrenia and healthy controls. Methods: Ninety-six patients with schizophrenia and 63 healthy controls comprised the study population. The participants were separated into three groups: inactive, low activity, and sufficiently active according to International Physical Activity Questionnaire short form (IPAQ-SF). We measured irisin levels using Enzyme linked immunosorbent assay. We also calculated exercise levels by using the IPAQ-SF for each individual. The independent samples t test was used in the data analysis to compare irisin levels according to the activity levels of the patients with schizophrenia and controls. Results: The levels of irisin were higher in the healthy controls (p < 0.001) compared to schizophrenia groups. When the activity levels of the schizophrenia and healthy control groups were compared, the irisin levels of the low activity and sufficiently active groups with schizophrenia were found to be lower than those of the low activity and sufficiently active groups in the healthy controls (respectively p = 0.014; p < 0.001). Conclusion: Irisin levels could be affected by physical activity and these results must be supported with new studies.

Stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of liver metastases in oligometastatic patients: initial clinical experience

Gamze Ugurluer,Teuta Zoto Mustafayev,Gorkem Gungor,Banu Atalar,Ufuk Abacioglu,Meric Sengoz,Fulya Agaoglu,Gokhan Demir,Enis Ozyar 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.1

Purpose: We aimed to present our initial clinical experience on the implementation of a stereotactic M2021-04-26methods for treatment of liver metastases in oligometastatic disease with the advantages of better visualization of soft tissue, real-time tumor tracking and potentially reduced toxicity to organs at risk.

Effect of bosentan on the production of proinflammatorycytokines in a rat model of emphysema

Gamze Kırkıl,Mehmet Hamdi Muz,Figen Deveci,Teyfik Turgut,Fulya İ,lhan,İ,brahim Ö,zercan 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.5

Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to investigate the anti-inflammatory potential of bosentan on a rat model of emphysema. Thirty Wistar male rats were classified as control group (group 1), intratracheally (i.t.) instilled with saline, treated with vehicle solution; elastase group (group 2), i.t. instilled with porcine pancreatic elastase (PPE), treated with vehicle solution; and PPE+bosentan group (group 3), i.t. instilled with PPE, treated with bosentan. The levels of TNF-α, IL-1β, IL-6, and IL-8 in bronchoalveolar lavage fluid (BALF) and lung tissue, cell counts in BALF, and histologic analysis of all groups were evaluated. Neutrophile granulocytes (NG) and alveolar macrophages (AM) were increased more in group 2 than in group 1 (P < 0.001, P = 0.04, respectively). Compared with group 2, neutrophil granulocyte (NG) and alveolar macrophages (AM) counts were decreased in group 3 (P < 0.001). Histological examination confirmed a diffuse neutrophilic inflammation and irregular alveolar air space enlargement in group 2. Treatment with bosentan partially reduced the enlarged lung volumes. Compared with group 1, the BALF levels of TNF-α and IL-6, and the lung tissue levels of IL-1β, IL-6, and IL-8 were increased in group 2 (P = 0.028, P = 0.005, P = 0.001, P = 0.019, P < 0.001, respectively). The TNF-α and IL-8 levels of BALF (P = 0.007, P = 0.001, respectively), and the TNF-α, IL-1β, IL-6, and the IL-8 levels of lung tissue (P = 0.031, P = 0.017, P = 0.007, P < 0.001) were decreased in group 3 compared to group 2. In conclusion, bosentan decreased the inflammatory response by reducing numbers of inflammatory cells and proinflammatory cytokines.

Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Gamze Erzin,Güven Özkaya,Canan Topçuoğlu,Rabia Nazik Yüksel,Özcan Erel,Emine Feyza Yurt,Erol Göka,Sinan Gülöksüz 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.3

Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls. Methods: Patients admitted to the outpatient clinic of Ankara Numune Training and Research Hospital and diagnosed either as a depressive episode with bipolar disorder (n = 37) or unipolar depression (n = 24) according to DSM-5 criteria, along with healthy controls (HC) (n = 50), were included in the study. Native thiol, total thiol, and disulfide levels were compared across the groups. Results: In comparison to HC, both BD and UD groups had higher disulfide levels, disulfide/native thiol ratio, and disulfide/total thiol ratio. No significant differences between BD and UD were detected in terms of disulfide level, disulfide/ native thiol ratio, and disulfide/total thiol ratio. Conclusion: Increased levels of disulfide, native thiol, and disulfide/total thiol ratios compared to healthy controls in both UD and BD groups may be indicative of the presence of oxidative damage in these two clinical conditions. To clarify the role of oxidative stress in the pathophysiology of depressive disorders and investigate TDH, longitudinal studies in patients with medication-free UD and BD are required.

Comparison of Physiotherapy Approaches in Low Back Pain: A Randomized Controlled Trial

Gamze Senbursa,Nihan Ozunlu Pekyavas,Gul Baltaci 대한가정의학회 2021 Korean Journal of Family Medicine Vol.42 No.2

Background: The purpose of this study was to compare the effectiveness of rehabilitation approaches in individuals with low back pain (LBP) on pain, spinal mobility, disability, and muscular strength. Methods: Ninety volunteers were included and divided into four groups depending on the rehabilitation approach: group 1, soft tissue mobilization techniques and stabilization exercises (n=24; 11 females [F], 13 males [M]); group 2, Kinesio Taping and stabilization exercises (n=24; 12F, 12M); group 3, stabilization exercises (n=22; 11F, 11M); and group 4, reflex therapy and stabilization exercises (n=20; 10F, 10M). Visual Analog Scale for pain intensity, an isokinetic evaluation for strength at 60°/s and a side-plank position test for trunk stabilization were measured before and assessed at the beginning, after a 4-week treatment and during 4 weeks of follow-up. The functional status was evaluated with the Oswestry Disability Index. Results: Individuals in all groups showed similar decrease in pain after the treatment and at 1-month follow-up, but there were no significant differences in pain levels between the groups (P<0.05). Conclusion: All therapeutic approaches were found to be effective in diminishing pain and thus helpful in increasing strength and stabilization in patients with LBP.

Methacrylate Polymers Having Pendant Chalcone Moieties

Gamze Barim,Ozgul Altun,Mustafa Gokhun Yayla 한국고분자학회 2015 폴리머 Vol.39 No.1

A new methacrylate copolymer that includes chalcone as a side group, poly(4-methacryloyloxyphenyl-4"-methoxystyryl ketone-co-styrene) was synthesized by free radical copolymerization. FTIR and 1H NMR spectroscopic techniques were used to characterize the homopolymers and copolymers. The copolymerizations were carried out to high conversions. Copolymer compositions were established by 1H NMR spectra analysis. The monomer reactivity ratios for copolymer system were determined by the linearized Kelen Tudos, and Extended Kelen Tudos methods and a non-linear least squares method. The molecular weights and polydispersity index of copolymers were measured by using the gel permeation chromatography (GPC). The effect of copolymer compositions on their thermal behavior were studied by differential scanning calorimetry and thermogravimetric analysis methods. The optical properties of the resulting copolymer were also investigated.

Nonlinear finite element analysis of ultra-high performance fiber reinforced concrete beams subjected to impact loads

Gamze Demirtas,Naci Caglar,Yusuf Sumer 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.82 No.1

Ultra-high performance fiber reinforced concrete (UHPFRC) is a composite building material with high ductility, fatigue resistance, fracture toughness, durability, and energy absorption capacity. The aim of this study is to develop a nonlinear finite element model that can simulate the response of the UHPFRC beam exposed to impact loads. A nonlinear finite element model was developed in ABAQUS to simulate the real response of UHPFRC beams. The numerical results showed that the model was highly successful to capture the experimental results of selected beams from the literature. A parametric study was carried out to investigate the effects of reinforcement ratio and impact velocity on the response of the UHPFRC beam in terms of midpoint displacement, impact load value, and residual load-carrying capacity. In the parametric study, the nonlinear analysis was performed in two steps for 12 different finite element models. In the first step, dynamic analysis was performed to monitor the response of the UHPFRC beam under impact loads. In the second step, static analysis was conducted to determine the residual load-carrying capacity of the beams. The parametric study has shown that the reinforcement ratio and the impact velocity affect maximum and residual displacement value substantially.

Health Tourism with Data Mining: Present State and Future Potentials

Gamze Kose,Osman Eralp Colakoglu 한국디지털융합학회 2023 IJICTDC Vol.8 No.1

Health Tourism is a trendy interest area as it allows individuals to travel another country for receiving health services while experiencing touristic opportunities. There are many benefits of health tourism in terms of costs, services, and experiences. By combining both health and tourism area, it welcomes many research directions in not only healthcare and tourism but also marketing and business management. Among these the area of Health Tourism is intensively connected with digital solutions since it is important to reach out individuals in different countries and enabling them to decide and come to the host country for receiving services. So, the data is very important for establishing innovative Health Tourism applications. However, one question arising is about how to analyze, process and use the data effectively within the purposes of such applications. This paper tries to answer this question from the perspective of Data Mining. As the Data Mining allows creating descriptive and predictive new knowledge from the known data, its use in digital Health Tourism applications has a remarkable value. In this context, this paper firstly ensures the connection between Health Tourism and Data Mining, and then discusses about present state as well as the future. It is believed that the outcomes from this paper will be a triggering factor for further research in Data Mining, which is currently a niche application way in Health Tourism.

Physiological Responses of the Mediterranean Subtidal Alga Peyssonnelia squamaria to Elevated CO2

Gamze Yıldız 한국해양과학기술원 2018 Ocean science journal Vol.53 No.4

The ecological consequences of ocean acidification are unclear due to varying physiological properties of macroalgae and species-specific responses. Therefore, in the present study, we used a laboratory culture experiment to analyse the eco-physiological responses of the Mediterranean subtidal red alga Peyssonnelia squamaria to CO2-induced lower pH. Our results showed an increase in the photosynthetic performance and growth rate of P. squamaria, despite the reduction in CaCO3 content in the low pH treatment. According to our results, we believe that samples exposed to elevated CO2 could be regulated own nitrogen metabolism to support increased growth rate and it may be down-regulated nitrate uptake. As a result, we hypothesize that P. squamaria may benefit from ocean acidification.

Health Tourism Awareness of Health Professionals : Views on General Perspective and Digital Transformation

Gamze Kose,Ozgur Ates 한국디지털융합학회 2023 IJICTDC Vol.8 No.2

As in every sector, employees contribute to health tourism. Since the subject is health, the approach of health professionals should be positive and their knowledge should be sufficient. It is important when the general awareness is thought and it was connected with the latest trends including even digital transformation. So, the connection among health professionals and the most recent factors regarding awareness should be examined by evaluating accordingly feedback from the area. This research addresses the main theme of health tourism awareness of health professionals and aims to illuminate the perspectives of employees on digital transformation in this dynamic field. The findings illustrate the enrichment of important intersections between health professionals and the expanding field of health tourism.