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Kim, Taehyun,Gadotti, Dimitri A.,Sheth, Kartik,Athanassoula, E.,Bosma, Albert,Lee, Myung Gyoon,Madore, Barry F.,Elmegreen, Bruce,Knapen, Johan H.,Zaritsky, Dennis,Ho, Luis C.,Comeró,n, Sé IOP Publishing 2014 The Astrophysical journal Vol.782 No.2
<P>We have performed two-dimensional multicomponent decomposition of 144 local barred spiral galaxies using 3.6 mu m images from the Spitzer Survey of Stellar Structure in Galaxies. Our model fit includes up to four components (bulge, disk, bar, and a point source) and, most importantly, takes into account disk breaks. We find that ignoring the disk break and using a single disk scale length in the model fit for Type II (down-bending) disk galaxies can lead to differences of 40% in the disk scale length, 10% in bulge-to-total luminosity ratio (B/T), and 25% in bar-to-total luminosity ratios. We find that for galaxies with B/T >= 0.1, the break radius to bar radius, r(br)/R-bar, varies between 1 and 3, but as a function of B/T the ratio remains roughly constant. This suggests that in bulge-dominated galaxies the disk break is likely related to the outer Lindblad resonance of the bar and thus moves outward as the bar grows. For galaxies with small bulges, B/T < 0.1, r(br)/R-bar spans a wide range from 1 to 6. This suggests that the mechanism that produces the break in these galaxies may be different from that in galaxies with more massive bulges. Consistent with previous studies, we conclude that disk breaks in galaxies with small bulges may originate from bar resonances that may be also coupled with the spiral arms, or be related to star formation thresholds.</P>
Kim, Taehyun,Sheth, Kartik,Hinz, Joannah L.,Lee, Myung Gyoon,Zaritsky, Dennis,Gadotti, Dimitri A.,Knapen, Johan H.,Schinnerer, Eva,Ho, Luis C.,Laurikainen, Eija,Salo, Heikki,Athanassoula, E.,Bosma, Al IOP Publishing 2012 The Astrophysical journal Vol.753 No.1
<P>Tidal debris around galaxies can yield important clues on their evolution. We have identified tidal debris in 11 early-type galaxies (T <= 0) from a sample of 65 early types drawn from the Spitzer Survey of Stellar Structure in Galaxies (S(4)G). The tidal debris includes features such as shells, ripples, and tidal tails. A variety of techniques, including two-dimensional decomposition of galactic structures, were used to quantify the residual tidal features. The tidal debris contributes similar to 3%-10% to the total 3.6 mu m luminosity of the host galaxy. Structural parameters of the galaxies were estimated using two-dimensional profile fitting. We investigate the locations of galaxies with tidal debris in the fundamental plane and Kormendy relation. We find that galaxies with tidal debris lie within the scatter of early-type galaxies without tidal features. Assuming that the tidal debris is indicative of recent gravitational interaction or merger, this suggests that these galaxies have either undergone minor merging events so that the overall structural properties of the galaxies are not significantly altered, or they have undergone a major merging events but already have experienced sufficient relaxation and phase mixing so that their structural properties become similar to those of the non-interacting early-type galaxies.</P>
Comeró,n, Sé,bastien,Elmegreen, Bruce G.,Salo, Heikki,Laurikainen, Eija,Athanassoula, E.,Bosma, Albert,Knapen, Johan H.,Gadotti, Dimitri A.,Sheth, Kartik,Hinz, Joannah L.,Regan, Michael W. IOP Publishing 2012 The Astrophysical journal Vol.759 No.2
<P>Breaks in the radial luminosity profiles of galaxies have until now been mostly studied averaged over disks. Here, we study separately breaks in thin and thick disks in 70 edge-on galaxies using imaging from the Spitzer Survey of Stellar Structure in Galaxies. We built luminosity profiles of the thin and thick disks parallel to midplanes and we found that thin disks often truncate (77%). Thick disks truncate less often (31%), but when they do, their break radius is comparable with that in the thin disk. This suggests either two different truncation mechanisms-one of dynamical origin affecting both disks simultaneously and another one only affecting the thin disk-or a single mechanism that creates a truncation in one disk or in both depending on some galaxy property. Thin disks apparently antitruncate in around 40% of galaxies. However, in many cases, these antitruncations are an artifact caused by the superposition of a thin disk and a thick disk, with the latter having a longer scale length. We estimate the real thin disk antitruncation fraction to be less than 15%. We found that the ratio of the thick and thin stellar disk mass is roughly constant (0.2 < M-T/M-t < 0.7) for circular velocities v(c) > 120 km s(-1), but becomes much larger at smaller velocities. We hypothesize that this is due to a combination of a high efficiency of supernova feedback and a slower dynamical evolution in lower-mass galaxies causing stellar thin disks to be younger and less massive than in higher-mass galaxies.</P>
Kim, Jin Han,Jeong, Hui Rak,Jung, Da Woon,Yoon, Hong Bin,Kim, Sun Young,Kim, Hyoung Ja,Lee, Kyung-Tae,Gadotti, Vinicius M.,Huang, Junting,Zhang, Fang-Xiong,Zamponi, Gerald W.,Lee, Jae Yeol Pergamon 2017 Bioorganic & medicinal chemistry Vol.25 No.17
<P><B>Abstract</B></P> <P>As a bioisosteric strategy to overcome the poor metabolic stability of lead compound KYS05090S, a series of new fluoro-substituted 3,4-dihydroquinazoline derivatives was prepared and evaluated for T-type calcium channel (Ca<SUB>v</SUB>3.2) block, cytotoxic effects and liver microsomal stability. Among them, compound <B>8h</B> (KCP10068F) containing 4-fluorobenzyl amide and 4-cyclohexylphenyl ring potently blocked Ca<SUB>v</SUB>3.2 currents (>90% inhibition) at 10μM concentration and exhibited cytotoxic effect (IC<SUB>50</SUB> =5.9μM) in A549 non-small cell lung cancer cells that was comparable to KYS05090S. Furthermore, <B>8h</B> showed approximately a 2-fold increase in liver metabolic stability in rat and human species compared to KYS05090S. Based on these overall results, <B>8h</B> (KCP10068F) may therefore represent a good backup compound for KYS05090S for further biological investigations as novel cytotoxic agent. In addition, compound <B>8g</B> (KCP10067F) was found to partially protect from inflammatory pain via a blockade of Ca<SUB>v</SUB>3.2 channels.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Meidt, Sharon E.,Schinnerer, Eva,Knapen, Johan H.,Bosma, Albert,Athanassoula, E.,Sheth, Kartik,Buta, Ronald J.,Zaritsky, Dennis,Laurikainen, Eija,Elmegreen, Debra,Elmegreen, Bruce G.,Gadotti, Dimitri IOP Publishing 2012 The Astrophysical journal Vol.744 No.1
<P>With the aim of constructing accurate two-dimensional maps of the stellar mass distribution in nearby galaxies from Spitzer Survey of Stellar Structure in Galaxies 3.6 and 4.5 mu m images, we report on the separation of the light from old stars from the emission contributed by contaminants. Results for a small sample of six disk galaxies (NGC 1566, NGC 2976, NGC 3031, NGC 3184, NGC 4321, and NGC 5194) with a range of morphological properties, dust content, and star formation histories are presented to demonstrate our approach. To isolate the old stellar light from contaminant emission (e.g., hot dust and the 3.3 mu m polycyclic aromatic hydrocarbon (PAH) feature) in the IRAC 3.6 and 4.5 mu m bands we use an independent component analysis (ICA) technique designed to separate statistically independent source distributions, maximizing the distinction in the [3.6]-[4.5] colors of the sources. The technique also removes emission from evolved red objects with a low mass-to-light ratio, such as asymptotic giant branch (AGB) and red supergiant (RSG) stars, revealing maps of the underlying old distribution of light with [3.6]-[4.5] colors consistent with the colors of K and M giants. The contaminants are studied by comparison with the non-stellar emission imaged at 8 mu m, which is dominated by the broad PAH feature. Using the measured 3.6 mu m/8 mu m ratio to select individual contaminants, we find that hot dust and PAHs together contribute between similar to 5% and 15% to the integrated light at 3.6 mu m, while light from regions dominated by intermediate-age (AGB and RSG) stars accounts for only 1%-5%. Locally, however, the contribution from either contaminant can reach much higher levels; dust contributes on average 22% to the emission in star-forming regions throughout the sample, while intermediate-age stars contribute upward of 50% in localized knots. The removal of these contaminants with ICA leaves maps of the old stellar disk that retain a high degree of structural information and are ideally suited for tracing stellar mass, as will be the focus in a companion paper.</P>