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Effects of probiotic CS-32 as a feed additive on growth performance of broiler chickens
Seong Soo Kang, Se Eun Kim, Ga Hoi Choi, Kyung Mi Shim, Jong Choon Kim, Jin Cheol Yo, Seung Sik Cho 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.3
In the livestock feed industry, antibiotics are used to prevent disease, promote growth rate, and improve feed efficiency. However, antibiotic supplementation to animal feed results in increased bacterial resistance to antibiotics as well as antibiotic residues in animal products, which can negatively affect human health. Therefore, alternative sources of antibiotics are needed. Probiotics as an alternative to antibiotics in animal feed have been shown to increase feed efficiency and growth rate by improving microbial balance. Further, Bacillus sp. produces a wide spectrum of antibacterial peptides. The present study was conducted to investigate the effects of dietary supplementation with CS-32 on safety, growth rate, and feed efficiency. Antibacterial substance (5697.9 molecular weights) produced by CS-32 was isolated and purified from culture broth. Moreover, the results of minimal inhibitory concentration (MIC) test confirmed the excellent antibacterial effect of CS-32. In vivo, 0.1% and 1% CS-32 were fed to broiler chickens for 28 days. Feed efficiency was slightly higher in groups of chickens supplemented with 0.1% and 1% CS-32 than those of the control group. CS-32 had no significant effect on necropsy findings, hematology, or serum biochemistry, and there was no mortality. These results suggest that CS-32 among various biologically active substances may be safe and effective as a feed additive to improve growth rate and feed efficiency.
Mi-Dan Kang,Ga-Young Kim,Hyeon-Ji Jeon,Young-Hoon Jung 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Lipases are one of the widely used biocatalysts that can hydrolyze and synthesize esters in various reactions. In this study, a recombinant lipase derived from Lactobacillus rhamnosus IDCC 3201 was constructed. It was expressed in Escherichia coli BL21 (DE3) using pET-21a(+) vector and the produced His-tagged lipase was purified by Ni-NTA affinity chromatography. Molecular size of a lipase was showing approximately 24 kDa by SDS-PAGE. The purified lipase was successfully releasing fatty acids, showing olive oil as a on the chromogenic plate containing olive oil as a substrate. The maximum lipase activity (3438.5 U/mg) was observed at 60℃ and the activity was maintained until 90℃. In addition, at different pH of 7.0 to 11.0, the lipase activity was retained more than 70% activity. However, the addition of various cofactors did not show positive effects on enzyme activities. Also, among C10 to C18 chemicals, para-nitrophenyl laurate showed highest value of enzyme activities. In conclusion, the lipase from L. rhamnosus IDCC 3201 has high thermostable and pH-stable properties and can utilize a wide range of substrates which makes it a potential candidate for using in industry.
S-454 : Does timing of adjuvant chemotherapy for gastric cancer influence outcome?
( Ga Won Song ),( Mi Sun Ahn ),( Jin Hyuk Choi ),( Seok Yun Kang ),( Hyun Woo Lee ),( Yong Kwan Cho ),( Sang Uk Han ),( Hoon Hur ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: According to recent large phase III trials, adjuvant chemotherapy is currently established as standard treatment in patients with stage II, III gastric cancer. However, to the authors` knowledge, the effect of the interval between surgery and the start of chemotherapy on outcome has not been investigated. Methods: A retrospective review was conducted of 716 patients who underwent adjuvant chemotherapy for stage IB-IIIC (AJCC 7th edition) gastric cancer after radical surgery with D2 dissection between 1994 and 2004 at the Ajou University Hospital. Overall survival (OS) was compared among patients grouped by time from surgery to start of adjuvant chemotherapy. Results: In terms of chemotherapy regimens, 5-FU/mitomycin-C-based (61.3%) was the most commonly used regimen, followed by 5-FU/doxorubicin-based one (16.9%), oral fluoropyrimidines (10.3%) and others (11.4%). The median time from surgery to chemotherapy was 20 days (range: 4-105 days), while 114 patients (15.9%) began adjuvant chemotherapy >4 weeks after surgery. The median follow-up duration was 152 months (range: 97-222 months) for the survivors. There was no significant difference in 10 year-OS between patients starting chemotherapy ≤ 20 days after surgery and those initiating later (51.2% vs. 48.5%, p=0.896). Commencing chemotherapy 4 weeks, 6 weeks and 8 weeks after surgery was not associated with inferior OS, compared with earlier initiation at each time interval (p=0.183, 0.739, 0.434, respectively). Even very early initiation of chemotherapy (≤ 2 weeks after surgery) did not correlate with better outcome (p=0.579). Conclusion: This study did not demonstrate any significant survival benefit from early initiation of adjuvant chemotherapy after surgery.
Ga Young Kim,Mi Dan Kang,Hyeon Ji Jeon,Young Hoon Jung 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Microfibrilated cellulose (MFC) is attracting attention with excellent mechanical strength, flexibility, miscibility, bio-degradability, and thermal stability. In this study, MFC was produced using various food peels such as silver skin (SS), grapefruit (GF), and sweet pumpkin (SP) and the potentiality of using as a nanocomposite was investigated. Among three different alkaline solvents including KOH, NaClO₂, and NaOH pretreated food peels showed a higher glucan recovery yield from 21.69 % to 29.62 % than KOH and NaClO₂. Also, the subsequent blending for 80 min gave better properties of MFC with respect to water retention value and sedimentation results. Each the width of produced MFCs were measured 60.56 nm (GF), 44.29 nm (SS), and 226.03 nm (SP). Subsequently, PLA-MFC composites with 1 phr MFC were prepared by melt compounding at 180 ℃ and 50 rpm for 10 min. Thermal analysis result between various physicochemical analyzes showed a little increased glass transition point and temperature resistance above 48 °C. Therefore, the tensile strength was comparable to that of PLA. In conclusion, the food peels pretreated with NaOH can be applied as a PLA-based bio-degradable complex.
나이아신 펩타이드 융합체의 피부 미백 소재로서의 기능성 평가
김가연(Ga Yeon Kim),이승제(Seung Je Lee),전미지(Mi Ji Jeon),김보민(Bo Min Kim),김근태(Geun Tae Kim),강상문(Sang Moon Kang),이기영(Kee Young Lee),신은진(Eun Jin Shin),김상용(Sang Yong Kim),김영민(Young Min Kim) 한국생물공학회 2018 KSBB Journal Vol.33 No.1
The purpose of this study was to investigate the skin-whitening effects of Niacinamide-dipeptide Convergence (Niacin-peptide). To evaluate skin-whitening effects of Niacin-peptide, we performed tyrosinase inhibition assay and L-DOPA oxidation inhibition assay. These results demonstrated that Niacin-peptide decreased melanin production through tyrosinase inhibition. Also, we measured expression level of melanogenesis-related mRNA and proteins by reverse transcription-polymerase chain reaction (PCR) and western blotting. Results of PCR and Western blotting were showed that Niacin-peptide reduced expression of microphthalmia- associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), tyrosinase related protein-2 (TRP- 2) and tyrosinase. Thus, we identified the skin-whitening effect of Niacin-peptide and this finding demonstrated that Niacinamide-dipeptide Convergence may have potential as cosmetic ingredient.
증례 : 류마티스 ; 피부근염 환자에서 발생한 창자벽 공기 낭증 -증례보고와 문헌고찰-
유미연 ( Mi Yeon Yu ),이강록 ( Kang Lok Lee ),박재근 ( Jae Keun Park ),안가영 ( Ga Young Ahn ),손창남 ( Chang Nam Son ),조온구 ( On Koo Cho ),전재범 ( Jae Bum Jun ) 대한내과학회 2015 대한내과학회지 Vol.88 No.4
PCI는 피부근염에서 발생할 수 있는 드문 합병증으로 증례가 매우 적어 정확한 원인 및 위험인자에 대해 잘 알려지지 않았다. 본 증례 및 이전 논문의 증례를 토대로 볼 때 일반적으로 PCI에서의 위험 요소로 고려되는 코르티코스테로이드 및 면역 억제제를 피부근염에서의 PCI 위험인자로 단정하기는 어려울 것으로 보인다. 다만 전체 PCI 중 피부근염에서 발생하는 PCI가 여성에서 발병되는 비율이 높은 것으로 관찰되어 이를 위험인자로 고려할 수 있다. 피부근염 환자에서 발생하는 PCI를 조기에 진단하고 치료하여 환자의 생존율을 높일 수 있도록 이러한 성별 및 추가적인 위험인자에 대해 다기관 및 전향적인 연구가 시행되어야 할 것으로 생각된다. Pneumatosis cystoides intestinalis (PCI) is a rare disease with intramural gas formation in the gastrointestinal tract. The causes of PCI are various, and are commonly associated with collagen vascular disease. We present a case of a 48-year-old female with dermatomyositis (DM) who also developed PCI. Her risk of PCI may have been increased by multiple factors such as gender, DM itself, and medications including corticosteroids, methotrexate, and azathioprine. While the cause of, and risk factors for PCI in DM patients are not well known on a global scale, outcomes range from benign to life threatening. Therefore, we present a case study and review the literature to identify candidate risk factors for PCI.
Lee, Ga-Young,Lee, Hu-Ryul,Um, Myeong-Heon,Kang, Mi-Sook Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.9
To investigate the scattering layer effect of a $TiO_2$ multilayer in dye-sensitized solar cells (DSSCs), we designed a new DSSC system, assembled with a CdS-$TiO_2$ scattering layer electrode. A high-magnification SEM image exhibited hollyhock-like particles with a width of 1.5-2.0 ${\mu}m$ that were aggregated into 10-nm clumps in a hexagonal petal shape. The efficiency was higher in the DSSC assembled with a CdS-$TiO_2$ scattering layer than in the DSSC assembled with $TiO_2$-only layers, due to the decreased resistance in electrochemical impedance spectroscopy (EIS). The short-circuit current density ($J_{sc}$) was increased by approximately 7.26% and the open-circuit voltage ($V_{oc}$) by 2.44% over the 1.0 wt % CdS-$TiO_2$ composite scattering layer and the incident photon-to-current conversion efficiency (IPCE) in the maximum peak was also enhanced by about 5.0%, compared to the DSSC assembled without the CdS-$TiO_2$scattering layer.